A
Arnold J. Levine
Researcher at Institute for Advanced Study
Publications - 493
Citations - 122094
Arnold J. Levine is an academic researcher from Institute for Advanced Study. The author has contributed to research in topics: Gene & Mutant. The author has an hindex of 139, co-authored 485 publications receiving 116005 citations. Previous affiliations of Arnold J. Levine include Harvard University & Affymetrix.
Papers
More filters
Journal ArticleDOI
Tryptic fingerprint analysis of adenovirus types 2, 5 and 12 DNA-Binding proteins.
TL;DR: The peptide fingerprints of the adenovirus type 2, 72,000-MW protein synthesized in either human or monkey cells are very similar or identical.
Journal ArticleDOI
Probing potential binding modes of the p53 tetramer to DNA based on the symmetries encoded in p53 response elements
Buyong Ma,Arnold J. Levine +1 more
TL;DR: The probabilities evaluated with molecular dynamics simulations and DNA sequence analyses were found to be correlated, indicating that the p53 tetramer models studied here are able to read DNA sequence information, and suggests that p53 needs balanced binding modes to maintain genome stability.
Journal ArticleDOI
Mutant p53 protein, master regulator of human malignancies: A report on the fifth Mutant p53 Workshop
Giovanni Blandino,Wolfgang Deppert,Pierre Hainaut,Arnold J. Levine,Guillermina Lozano,Magali Olivier,Varda Rotter,K G Wiman,Moshe Oren +8 more
TL;DR: Researchers from diverse international backgrounds gathered in May 2011 for the Fifth Mutant p53 Workshop, which took place in the magnificent Chigi Palace in Ariccia, Italy.
Journal ArticleDOI
Lysine methylation represses p53 activity in teratocarcinoma cancer cells
TL;DR: It is reported that in the teratocarcinoma cell line NTera2, p53 is subject to lysine methylation at its carboxyl terminus, which has been shown to repress p53’s transcriptional activity, providing evidence that lysines methylation of endogenous wild-type p53 represses its activity in cancer cells.
Journal ArticleDOI
Two well-differentiated pancreatic neuroendocrine tumor mouse models
Chung Wong,Laura H. Tang,Christian Davidson,Evan Vosburgh,Wenjin Chen,David J. Foran,Daniel A. Notterman,Arnold J. Levine,Eugenia Y. Xu +8 more
TL;DR: The MPR and MPM mouse models are the first to underscore the cooperative roles of Men1 and Pten in cancer, particularly neuroendocrine cancer, through targeting the MENIN-mediated and PI3K/AKT/mTOR signaling pathways.