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Arnold J. Levine
Researcher at Institute for Advanced Study
Publications - 493
Citations - 122094
Arnold J. Levine is an academic researcher from Institute for Advanced Study. The author has contributed to research in topics: Gene & Mutant. The author has an hindex of 139, co-authored 485 publications receiving 116005 citations. Previous affiliations of Arnold J. Levine include Harvard University & Affymetrix.
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Methods of diagnosing pre-cancer or cancer states using probes for detecting mutant p53
TL;DR: A panel of probes that detect and distinguish between sets of human p53 gene or protein mutations that frequently occur or are selected for in pre-cancer and cancer cells.
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Characterization of human p53 antigens employing primate specific monoclonal antibodies
TL;DR: A radioimmunometric assay was employed to study the steady-state levels of oligomeric p53 in normal and transformed cell lines, and there was a great diversity in the levels of p53 antigen in human cells.
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Physical mapping of human cytomegalovirus genes: Identification of DNA sequences coding for a virion phosphoprotein of 71 kDa and a viral 65-kDa polypeptide
TL;DR: Polyadenylated RNA was isolated from fibroblast cultures infected with human cytomegalovirus strain AD169 during the late phase of viral replication and translated into an abundant 65-kDa polypeptide which had the same size as the major structural phosphoprotein of HCMV.
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Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer.
TL;DR: This work describes recent work defining a new class of drugs termed zinc metallochaperones that restore WT p53 structure and function by restoring Zn(2+) to Zn (2+)-deficient mutant p53.
Journal Article
Cyclin D1 and p21/waf1 are both involved in p53 growth suppression.
TL;DR: Accumulated evidence indicate that induction of both cyclin D1 and p21/waf1 are involved in establishing the p53-mediated growth arrest in murine cell lines expressing temperature sensitive p53 protein.