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Arron Cook
Researcher at UCL Institute of Neurology
Publications - 12
Citations - 702
Arron Cook is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: Spinocerebellar ataxia & Ataxia. The author has an hindex of 10, co-authored 12 publications receiving 445 citations. Previous affiliations of Arron Cook include University College London.
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Journal ArticleDOI
Long-term disease progression in spinocerebellar ataxia types 1, 2, 3, and 6: a longitudinal cohort study
Heike Jacobi,Sophie Tezenas du Montcel,Peter Bauer,Paola Giunti,Arron Cook,Robyn Labrum,Michael H Parkinson,Alexandra Durr,Alexis Brice,Perrine Charles,Cecilia Marelli,Caterina Mariotti,Lorenzo Nanetti,Marta Panzeri,Maria Rakowicz,Anna Sulek,Anna Sobanska,Tanja Schmitz-Hübsch,Ludger Schöls,Ludger Schöls,Holger Hengel,Holger Hengel,Laszlo Baliko,Béla Melegh,Alessandro Filla,Antonella Antenora,Jon Infante,José Berciano,Bart P.C. van de Warrenburg,Dagmar Timmann,Sandra Szymanski,Sylvia Boesch,Jun Suk Kang,Massimo Pandolfo,Jörg B. Schulz,Sonia Molho,Alhassane Diallo,Thomas Klockgether,Thomas Klockgether +38 more
TL;DR: This study provides quantitative data on the progression of the most common spinocerebellar ataxias based on a follow-up period that exceeds those of previous studies and could prove useful for sample size calculation and patient stratification in interventional trials.
Journal ArticleDOI
Friedreich's ataxia: clinical features, pathogenesis and management.
Arron Cook,Paola Giunti +1 more
TL;DR: Management of Freidreich's ataxia is currently focussed on symptomatic management, delivered by the multidisciplinary team, and the genetic and epigenetic mechanisms underlying the disease now offer promising novel therapeutic targets.
Journal ArticleDOI
Prediction of the age at onset in spinocerebellar ataxia type 1, 2, 3 and 6
Sophie Tezenas du Montcel,Alexandra Durr,Maria Rakowicz,Lorenzo Nanetti,Perrine Charles,Anna Sulek,Caterina Mariotti,Rafał Rola,Ludger Schöls,Peter Bauer,Isabelle Dufaure-Garé,Heike Jacobi,Sylvie Forlani,Sylvie Forlani,Tanja Schmitz-Hübsch,Alessandro Filla,Dagmar Timmann,Bart P.C. van de Warrenburg,Cecila Marelli,Jun Suk Kang,Paola Giunti,Arron Cook,Laszlo Baliko,Melegh Bela,Sylvia Boesch,Sandra Szymanski,José Berciano,Jon Infante,Katrin Buerk,Marcella Masciullo,Roberto Di Fabio,Chantal Depondt,Susanne Ratka,Giovanni Stevanin,Thomas Klockgether,Alexis Brice,Jean Louis Golmard +36 more
TL;DR: A regression model was fitted using a log-normal distribution for age at onset for each SCA genotype according to the CAG repeat size and current age, which can be valuable in clinical and research.
Journal ArticleDOI
A longitudinal investigation into cognition and disease progression in spinocerebellar ataxia types 1, 2, 3, 6, and 7
TL;DR: A trend of cognitive decline that is different for each SCA subtype, and for the majority is related to the severity of cerebellar motor impairment is suggested.
Journal ArticleDOI
Survival in patients with spinocerebellar ataxia types 1, 2, 3, and 6 (EUROSCA): a longitudinal cohort study.
Alhassane Diallo,Heike Jacobi,Arron Cook,Robyn Labrum,Alexandra Durr,Alexis Brice,Perrine Charles,Cecilia Marelli,Caterina Mariotti,Lorenzo Nanetti,Marta Panzeri,Maria Rakowicz,Anna Sobanska,Anna Sulek,Tanja Schmitz-Hübsch,Tanja Schmitz-Hübsch,Ludger Schöls,Holger Hengel,Béla Melegh,Alessandro Filla,Antonella Antenora,Jon Infante,José Berciano,Bart P.C. van de Warrenburg,Dagmar Timmann,Sylvia Boesch,Massimo Pandolfo,Jörg B. Schulz,Peter Bauer,Paola Giunti,Jun Suk Kang,Thomas Klockgether,Thomas Klockgether,Sophie Tezenas du Montcel +33 more
TL;DR: The results have implications for the design of future interventional studies of spinocerebellar ataxias; for example, the prognostic survival nomogram could be useful for selection and stratification of patients.