P
Perrine Charles
Researcher at German Center for Neurodegenerative Diseases
Publications - 79
Citations - 4139
Perrine Charles is an academic researcher from German Center for Neurodegenerative Diseases. The author has contributed to research in topics: Ataxia & Spinocerebellar ataxia. The author has an hindex of 31, co-authored 67 publications receiving 3227 citations.
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Journal ArticleDOI
Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders.
Markus Wolff,Katrine M Johannesen,Ulrike B. S. Hedrich,Silvia Masnada,Guido Rubboli,Elena Gardella,Gaetan Lesca,Gaetan Lesca,Dorothée Ville,Mathieu Milh,Laurent Villard,Alexandra Afenjar,Sandra Chantot-Bastaraud,Cyril Mignot,Caroline Lardennois,Caroline Nava,Niklas Schwarz,Marion Gérard,Laurence Perrin,Diane Doummar,Stéphane Auvin,Maria J Miranda,Maja Hempel,Eva H. Brilstra,Nine V A M Knoers,Nienke E. Verbeek,Marjan J. A. van Kempen,Kees P.J. Braun,Grazia M.S. Mancini,Saskia Biskup,Konstanze Hörtnagel,Miriam Döcker,Thomas Bast,Tobias Loddenkemper,Lily C. Wong-Kisiel,Friedrich A. M. Baumeister,Walid Fazeli,Pasquale Striano,Robertino Dilena,Elena Fontana,Federico Zara,Gerhard Kurlemann,Joerg Klepper,Jess G. Thoene,Daniel H. Arndt,Nicolas Deconinck,Thomas Schmitt-Mechelke,Oliver Maier,Hiltrud Muhle,Beverly Wical,Claudio Finetti,Reinhard Brückner,Joachim Pietz,Günther Golla,Dinesh V Jillella,Karen Markussen Linnet,Perrine Charles,Ute Moog,Eve Õiglane-Shlik,John F Mantovani,Kristen Park,Marie Deprez,Damien Lederer,Sandrine Mary,Emmanuel Scalais,Laila Selim,Rudy Van Coster,Lieven Lagae,Marina Nikanorova,Helle Hjalgrim,G. Christoph Korenke,Marina Trivisano,Nicola Specchio,Berten Ceulemans,Thomas Dorn,Katherine L. Helbig,Katia Hardies,Hannah Stamberger,Peter De Jonghe,Sarah Weckhuysen,Johannes R. Lemke,Ingeborg Krägeloh-Mann,Ingo Helbig,Ingo Helbig,Gerhard Kluger,Holger Lerche,Rikke S. Møller +86 more
TL;DR: Clinical and experimental data suggest a correlation between age at disease onset, response to sodium channel blockers and the functional properties of mutations in children with SCN2A-related epilepsy, and suggest that mutations associated with early infantile epilepsy result in increased sodium channel activity with gain-of-function.
Journal ArticleDOI
Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum
Giovanni Stevanin,Filippo M. Santorelli,Hamid Azzedine,Hamid Azzedine,Paula Coutinho,Jacques Chomilier,Paola S. Denora,Elodie Martin,Elodie Martin,Anne Marie Ouvrard-Hernandez,Alessandra Tessa,Naima Bouslam,Naima Bouslam,Alexander Lossos,Perrine Charles,José Leal Loureiro,N. Elleuch,N. Elleuch,Christian Confavreux,Vítor Tedim Cruz,Merle Ruberg,Merle Ruberg,Eric LeGuern,Eric LeGuern,D. Grid,Meriem Tazir,Bertrand Fontaine,Bertrand Fontaine,Alessandro Filla,Enrico Bertini,Alexandra Durr,Alexandra Durr,Alexis Brice +32 more
TL;DR: Ten mutations in a previously unidentified gene expressed ubiquitously in the nervous system but most prominently in the cerebellum, cerebral cortex, hippocampus and pineal gland are identified, suggesting a loss-of-function mechanism in ARHSP.
Journal ArticleDOI
Early energy deficit in Huntington disease: identification of a plasma biomarker traceable during disease progression.
Fanny Mochel,Perrine Charles,François Seguin,Julie Barritault,Christiane Coussieu,Laurence Perin,Yves Le Bouc,Christiane Gervais,Guislaine Carcelain,Anne Vassault,Josué Feingold,Daniel Rabier,Alexandra Durr +12 more
TL;DR: In this paper, a multivariate statistical analysis of plasma components quantified by proton nuclear magnetic resonance (1H NMR) spectroscopy was performed to identify early stages of the Huntington disease.
Journal ArticleDOI
Long-term disease progression in spinocerebellar ataxia types 1, 2, 3, and 6: a longitudinal cohort study
Heike Jacobi,Sophie Tezenas du Montcel,Peter Bauer,Paola Giunti,Arron Cook,Robyn Labrum,Michael H Parkinson,Alexandra Durr,Alexis Brice,Perrine Charles,Cecilia Marelli,Caterina Mariotti,Lorenzo Nanetti,Marta Panzeri,Maria Rakowicz,Anna Sulek,Anna Sobanska,Tanja Schmitz-Hübsch,Ludger Schöls,Ludger Schöls,Holger Hengel,Holger Hengel,Laszlo Baliko,Béla Melegh,Alessandro Filla,Antonella Antenora,Jon Infante,José Berciano,Bart P.C. van de Warrenburg,Dagmar Timmann,Sandra Szymanski,Sylvia Boesch,Jun Suk Kang,Massimo Pandolfo,Jörg B. Schulz,Sonia Molho,Alhassane Diallo,Thomas Klockgether,Thomas Klockgether +38 more
TL;DR: This study provides quantitative data on the progression of the most common spinocerebellar ataxias based on a follow-up period that exceeds those of previous studies and could prove useful for sample size calculation and patient stratification in interventional trials.
Journal ArticleDOI
Biological and clinical characteristics of individuals at risk for spinocerebellar ataxia types 1, 2, 3, and 6 in the longitudinal RISCA study: analysis of baseline data
Heike Jacobi,Kathrin Reetz,Kathrin Reetz,Sophie Tezenas du Montcel,Peter Bauer,Caterina Mariotti,Lorenzo Nanetti,Maria Rakowicz,Anna Sulek,Alexandra Durr,Perrine Charles,Alessandro Filla,Antonella Antenora,Ludger Schöls,Julia Schicks,Jon Infante,Jun Suk Kang,Dagmar Timmann,Roberto Di Fabio,Marcella Masciullo,Laszlo Baliko,Béla Melegh,Sylvia Boesch,Katrin Bürk,Annkathrin Peltz,Jörg B. Schulz,Isabelle Dufaure-Garé,Thomas Klockgether,Thomas Klockgether +28 more
TL;DR: Preclinical SCA1 and SCA2 mutation carriers seem to have mild coordination deficits and abnormalities in the brain that are more common in carriers who are closer to the estimated onset of ataxia.