A
Arthur M. Feldman
Researcher at Thomas Jefferson University
Publications - 296
Citations - 41891
Arthur M. Feldman is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Heart failure & Tumor necrosis factor alpha. The author has an hindex of 79, co-authored 289 publications receiving 40355 citations. Previous affiliations of Arthur M. Feldman include Johns Hopkins University School of Medicine & Valley Hospital.
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Journal ArticleDOI
Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon hearts
Charles F. McTiernan,Michael A. Mathier,Xiaodong Zhu,Xiao Xiao,E Klein,C H Swan,Haider Mehdi,Gregory A. Gibson,Anita M. Trichel,Joseph C. Glorioso,Arthur M. Feldman,Kenneth R. McCurry,Barry London +12 more
TL;DR: A cellular immune response to cardiac delivery of AAV encoding foreign proteins may be an important consideration for AAV-based cardiac gene therapy.
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Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis
Valerie D. Myers,Dhanendra Tomar,Muniswamy Madesh,JuFang Wang,Jianliang Song,Xue-Qian Zhang,Manish K. Gupta,Farzaneh G. Tahrir,Jennifer Gordon,Joseph M. McClung,Christopher D. Kontos,Kamel Khalili,Joseph Y. Cheung,Arthur M. Feldman +13 more
TL;DR: Results suggest that mice in which BAG3 has been deleted from a single allele provide a model that mirrors the biology seen in patients with heart failure and B AG3 haplo‐insufficiency.
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The role of tumor necrosis factor alpha in the pathophysiology of congestive heart failure.
TL;DR: Recent studies in both animal models and clinical investigations suggest that anti-TNF-α therapies may limit the pathophysiologic consequences of congestive heart failure.
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The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease.
Valerie D. Myers,Joseph M. McClung,JuFang Wang,Farzaneh G. Tahrir,Manish K. Gupta,Jennifer Gordon,Christopher H. Kontos,Kamel Khalili,Joseph Y. Cheung,Arthur M. Feldman +9 more
TL;DR: The B-cell lymphoma 2–associated anthanogene (BAG3) protein is expressed most prominently in the heart, the skeletal muscle, and in many forms of cancer, where it serves as a co-chaperone with heat shock proteins in facilitating autophagy.
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The balance between pro-apoptotic and anti-apoptotic pathways in the failing myocardium.
TL;DR: It is important to note that the adrenergic, reactive oxygen species, and proinflammatory cytokine signaling pathways are not the only pro-apoptotic pathways active in the myocardium, nor are IL-6-related cytokine, calcineurin, and IGF-1/P13K/Akt signaling pathways the only anti-apopotic pathwaysActive in theMyocardium.