A
Arthur M. Feldman
Researcher at Thomas Jefferson University
Publications - 296
Citations - 41891
Arthur M. Feldman is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Heart failure & Tumor necrosis factor alpha. The author has an hindex of 79, co-authored 289 publications receiving 40355 citations. Previous affiliations of Arthur M. Feldman include Johns Hopkins University School of Medicine & Valley Hospital.
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Journal ArticleDOI
Sex-related survival differences in murine cardiomyopathy are associated with differences in TNF-receptor expression.
TL;DR: In this article, the authors investigated the effect of TNF-α overexpression on the severity of congestive heart failure and mortality in female and male transgenic mice, and found that the 6-month survival rate was significantly better in females than in males.
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Effect of the Asp298 Variant of Endothelial Nitric Oxide Synthase on Survival for Patients With Congestive Heart Failure
Dennis M. McNamara,Richard Holubkov,Lisa A. Postava,Ravi Ramani,Karen Janosko,Michael A. Mathier,Guy A. MacGowan,Srinivas Murali,Arthur M. Feldman,Barry London +9 more
TL;DR: For patients with heart failure caused by systolic function, the Asp298 variant of NOS3 is associated with poorer event-free survival, particularly in patients with nonischemic cardiomyopathy.
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Calcium-dependent arrhythmias in transgenic mice with heart failure.
Barry London,Linda C. Baker,Joon S. Lee,Vladimir Shusterman,Bum-Rak Choi,Toru Kubota,Charles F. McTiernan,Arthur M. Feldman,Guy Salama +8 more
TL;DR: Both action potential prolongation and abnormal Ca(2+) handling may contribute to the initiation of reentrant arrhythmias in this heart failure model by mechanisms distinct from enhanced dispersion of refractoriness or triggered activity.
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Atrial contractile dysfunction, fibrosis, and arrhythmias in a mouse model of cardiomyopathy secondary to cardiac-specific overexpression of tumor necrosis factor-α
Samir Saba,Andrzej M. Janczewski,Linda C. Baker,Vladimir Shusterman,Erdal Gursoy,Arthur M. Feldman,Guy Salama,Charles F. McTiernan,Barry London +8 more
TL;DR: Alarming abnormalities in action potential propagation and Ca(2+) handling contribute to the initiation of atrial arrhythmias in this mouse model of heart failure.
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Expression of proinflammatory cytokines in the failing human heart: comparison of recent-onset and end-stage congestive heart failure.
Toru Kubota,Masayuki Miyagishima,Rene Alvarez,Robert L. Kormos,Warren D. Rosenblum,Anthony J. Demetris,Marc J. Semigran,G. William Dec,Richard Holubkov,Charles F. McTiernan,Douglas L. Mann,Arthur M. Feldman,Dennis M. McNamara +12 more
TL;DR: Cytokines are expressed in the myocardium in end-stage heart failure to a much greater degree than in patients with the recent onset of symptoms, and elevated plasma levels of TNF-alpha and IL-6 suggest induction of cytokines in theMyocardium is a relatively late event in the pathogenesis of CHF.