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Arthur M. Feldman
Researcher at Thomas Jefferson University
Publications - 296
Citations - 41891
Arthur M. Feldman is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Heart failure & Tumor necrosis factor alpha. The author has an hindex of 79, co-authored 289 publications receiving 40355 citations. Previous affiliations of Arthur M. Feldman include Johns Hopkins University School of Medicine & Valley Hospital.
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Journal ArticleDOI
Anti–Tumor Necrosis Factor-α Antibody Limits Heart Failure in a Transgenic Model
Toshiaki Kadokami,Carole S. Frye,Bonnie Lemster,Carrie Wagner,Arthur M. Feldman,Charles F. McTiernan +5 more
TL;DR: Blockade of TNF-&agr; bioactivity by antibody therapy may both preserve cardiac function and partially reverse pathological changes in congestive heart failure.
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Effects of Tumor Necrosis Factor Gene Polymorphisms on Patients With Congestive Heart Failure
Toru Kubota,Dennis M. McNamara,Jue J. Wang,Mary K. Trost,Charles F. McTiernan,Douglas L. Mann,Arthur M. Feldman +6 more
TL;DR: The prevalence of TNF gene polymorphisms in CHF patients and the correlation of genotypes to in vivo TNF-α levels were studied and there were no differences in the TNF allele frequencies between CHF and control subjects.
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Interleukin-1β Inhibits Phospholamban Gene Expression in Cultured Cardiomyocytes
Charles F. McTiernan,Bonnie Lemster,Carole S. Frye,Steven S. Brooks,Alain Combes,Arthur M. Feldman +5 more
TL;DR: It is demonstrated that IL-1 beta alters the expression of phospholamban, a key regulator of cardiac contractility, at both the transcript and protein levels, which suggest novel mechanisms by which IL- 1 beta may modify cardiac function.
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Aldosterone Synthase Promoter Polymorphism Predicts Outcome in African Americans With Heart Failure : Results From the A-HeFT Trial
Dennis M. McNamara,S. William Tam,Michael L. Sabolinski,Page Tobelmann,Karen Janosko,Anne L. Taylor,Jay N. Cohn,Arthur M. Feldman,Manuel Worcel +8 more
TL;DR: The aldosterone synthase promoter -344C allele linked to higher ald testosterone levels is associated with poorer event-free survival in blacks with heart failure, and the role of a Aldosterone receptor antagonists in diminishing this apparent genetic risk remains to be explored.
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Coxsackievirus B3 Induces T Regulatory Cells, Which Inhibit Cardiomyopathy in Tumor Necrosis Factor-α Transgenic Mice
TL;DR: The low TNF-α response during H310A1 infections is likely responsible for the T regulatory cell response in these animals, which reduces heart size and cardiac inflammation corresponding to the activation of CD4+CD25+FoxP3+ (T regulatory cells).