J
Justin T Biel
Researcher at University of California, San Francisco
Publications - 17
Citations - 914
Justin T Biel is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Conformational ensembles & Docking (molecular). The author has an hindex of 9, co-authored 16 publications receiving 470 citations. Previous affiliations of Justin T Biel include University of California, Berkeley.
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Journal ArticleDOI
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
David E. Gordon,Joseph Hiatt,Mehdi Bouhaddou,Veronica V. Rezelj,Svenja Ulferts,Hannes Braberg,Alexander S. Jureka,Kirsten Obernier,Jeffrey Z. Guo,Jyoti Batra,Robyn M. Kaake,Andrew R. Weckstein,Tristan W. Owens,Meghna Gupta,Sergei Pourmal,Erron W. Titus,Merve Cakir,Margaret Soucheray,Michael J. McGregor,Zeynep Cakir,Gwendolyn M. Jang,Matthew J. O’Meara,Tia A. Tummino,Ziyang Zhang,Helene Foussard,Ajda Rojc,Yuan Zhou,Dmitry Kuchenov,Ruth Hüttenhain,Jiewei Xu,Manon Eckhardt,Danielle L. Swaney,Jacqueline M. Fabius,Manisha Ummadi,Beril Tutuncuoglu,Ujjwal Rathore,Maya Modak,Paige Haas,Kelsey M. Haas,Zun Zar Chi Naing,Ernst H. Pulido,Ying Shi,Inigo Barrio-Hernandez,Danish Memon,Eirini Petsalaki,Alistair Dunham,Miguel Correa Marrero,David F. Burke,Cassandra Koh,Thomas Vallet,Jesus A. Silvas,Caleigh M. Azumaya,Christian B. Billesbølle,Axel F. Brilot,Melody G. Campbell,Melody G. Campbell,Amy Diallo,Miles Sasha Dickinson,Devan Diwanji,Nadia Herrera,Nick Hoppe,Huong T. Kratochvil,Yanxin Liu,Gregory E. Merz,Michelle Moritz,Henry C. Nguyen,Carlos Nowotny,Cristina Puchades,Alexandrea N. Rizo,Ursula Schulze-Gahmen,Amber M. Smith,Ming Sun,Iris D. Young,Jianhua Zhao,Daniel Asarnow,Justin T Biel,Alisa Bowen,Julian R. Braxton,Jen Chen,Cynthia M. Chio,Un Seng Chio,Ishan Deshpande,Loan Doan,Bryan Faust,Sebastian Flores,Mingliang Jin,Kate Kim,Victor L Lam,Fei Li,Junrui Li,Y. Li,Yang Li,Xi Liu,Megan Lo,Kyle E. Lopez,Arthur Alves de Melo,Frank R. Moss,Phuong Nguyen,Joana Paulino,Komal Ishwar Pawar,Jessica K. Peters,Thomas H. Pospiech,Maliheh Safari,Smriti Sangwan,Kaitlin Schaefer,Paul V. Thomas,Aye C. Thwin,Raphael Trenker,Eric Tse,Tsz Kin Martin Tsui,Feng Wang,Natalie Whitis,Zanlin Yu,Kaihua Zhang,Yang Zhang,Fengbo Zhou,Daniel J. Saltzberg,Anthony J. Hodder,Amber S. M. Shun-Shion,Daniel M. Williams,Kris M. White,Romel Rosales,Thomas Kehrer,Lisa Miorin,Elena Moreno,Arvind H. Patel,Suzannah J. Rihn,Mir M. Khalid,Albert Vallejo-Gracia,Parinaz Fozouni,Parinaz Fozouni,Camille R. Simoneau,Camille R. Simoneau,Theodore L. Roth,David Wu,Mohd Anisul Karim,Maya Ghoussaini,Ian Dunham,Francesco Berardi,Sebastian Weigang,Maxime Chazal,Jisoo Park,James Logue,Marisa McGrath,Stuart Weston,Robert Haupt,C. James Hastie,Matthew Elliott,Fiona Brown,Kerry A. Burness,Elaine Reid,Mark Dorward,Clare Johnson,Stuart G. Wilkinson,Anna Geyer,Daniel M. Giesel,Carla Baillie,Samantha Raggett,Hannah Leech,Rachel Toth,Nicola Goodman,Kathleen C. Keough,Abigail L. Lind,Reyna J. Klesh,Kafi R. Hemphill,Jared Carlson-Stevermer,Jennifer Oki,Kevin Holden,Travis J. Maures,Katherine S. Pollard,Katherine S. Pollard,Andrej Sali,David A. Agard,Yifan Cheng,James S. Fraser,Adam Frost,Natalia Jura,Tanja Kortemme,Aashish Manglik,Daniel R. Southworth,Robert M. Stroud,Dario R. Alessi,Paul Davies,Matthew B. Frieman,Trey Ideker,Carmen Abate,Nolwenn Jouvenet,Nolwenn Jouvenet,Georg Kochs,Brian K. Shoichet,Melanie Ott,Melanie Ott,Massimo Palmarini,Kevan M. Shokat,Adolfo García-Sastre,Jeremy A. Rassen,Robert Grosse,Oren S. Rosenberg,Kliment A. Verba,Christopher F. Basler,Marco Vignuzzi,Andrew A. Peden,Pedro Beltrao,Nevan J. Krogan +203 more
TL;DR: The authors identified shared biology and host-directed drug targets to prioritize therapeutics with potential for rapid deployment against current and future coronavirus outbreaks, and found that individuals with genotypes corresponding to higher soluble IL17RA levels in plasma are at decreased risk of COVID-19 hospitalization.
Journal ArticleDOI
An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.
Daniel A. Keedy,Z.B. Hill,Justin T Biel,E. Kang,T. Justin Rettenmaier,José Brandão-Neto,Nicholas M Pearce,Frank von Delft,Frank von Delft,James A. Wells,James S. Fraser +10 more
TL;DR: The ensemble nature of macromolecular structure can elucidate allosteric mechanisms and open new doors for long-range control of protein function by combining multiple-temperature X-ray crystallography experiments and structure determination from hundreds of individual small-molecule fragment soaks.
Journal ArticleDOI
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.
M. Schuller,Galen J. Correy,Stefan Gahbauer,D. Fearon,Taiasean Wu,Roberto Diaz,Iris D. Young,Luan Carvalho Martins,Dominique H. Smith,Ursula Schulze-Gahmen,Tristan W. Owens,Ishan Deshpande,Gregory E. Merz,Aye C. Thwin,Justin T Biel,Jessica K. Peters,Michelle Moritz,Nadia Herrera,Huong T. Kratochvil,A. Aimon,James M. Bennett,Jose Brandao Neto,Aina E. Cohen,Alexandre Dias,Alice Douangamath,Louise Dunnett,Oleg Fedorov,Matteo P. Ferla,Martin Fuchs,T.J. Gorrie-Stone,James M. Holton,James M. Holton,James M. Holton,Michael G. Johnson,T. Krojer,T. Krojer,George Meigs,George Meigs,A.J. Powell,Johannes Gregor Matthias Rack,Victor L. Rangel,Victor L. Rangel,Victor L. Rangel,Silvia Russi,R. Skyner,Clyde A. Smith,Alexei S. Soares,Jennifer L. Wierman,Kang Zhu,Peter O'Brien,Natalia Jura,Alan Ashworth,John J. Irwin,Michael C. Thompson,Jason E. Gestwicki,Frank von Delft,Brian K. Shoichet,James S. Fraser,Ivan Ahel +58 more
TL;DR: In this article, a massive crystallographic screening and computational docking effort, identifying new chemical matter primarily targeting the active site of the macrodomain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported.
Journal ArticleDOI
Keep on moving: discovering and perturbing the conformational dynamics of enzymes.
TL;DR: Understanding the conformational dynamics of larger systems such as protein machines will likely become more accessible and provide new opportunities to rationally modulate protein function.
Journal ArticleDOI
Synthetic group A streptogramin antibiotics that overcome Vat resistance
Qi Li,Jenna Pellegrino,D. John Lee,Arthur A Tran,Hector A Chaires,Ruoxi Wang,Jesslyn E Park,Kaijie Ji,David Chow,Na Zhang,Na Zhang,Axel F. Brilot,Justin T Biel,Gydo C. P. van Zundert,Kenneth W. Borrelli,Dean L. Shinabarger,Cindy Wolfe,Beverly Murray,Matthew P. Jacobson,Estelle Mühle,Olivier Chesneau,James S. Fraser,Ian B. Seiple +22 more
TL;DR: Modular synthesis and structural biology are used to design and characterize group A streptogramin antibiotics, one of which has activity against streptogramsin-resistant strains and demonstrates efficacy in a mouse model of bacterial infection.