Hari Krishna Ananthula

TL;DR: Two compounds found were highly effective in vitro and in vivo against several pathogenic fungi and were well tolerated by animals and additive to current antifungals, suggesting that these drugs might pave the way for the development of a new class of antIFungals.

TL;DR: Three out of 19 derivatives of BHBM were highly active against Cryptococcus neoformans in vitro and had low toxicity in mammalian cells, suggesting that acylhydrazones are promising molecules for the research and development of new antifungal agents.

TL;DR: Visesato Mor, a Antonella Rella, a Amir M. Farnoud, a Ashutosh Singh, a Mansa Munshi, a Arielle Bryan, a Shamoon Naseem, a James B. Konopka, a Iwao Ojima,b Erika Bullesbach,c Alan Ashbaugh,d Michael J. Linke, d,e Melanie Cushion,d,e Margaret Collins,e Hari Krishna Ananthula,

TL;DR: Prairie dogs and monkeys may be suitable rodent and non-rodent species to perform further efficacy testing of these TKIs against orthopoxvirus infections, and allometry-based correlations, derived from existing literature data, may serve as a useful guide for pre-clinical PK studies in untested animal models.