L
Lai Hong Wong
Researcher at University of British Columbia
Publications - 8
Citations - 200
Lai Hong Wong is an academic researcher from University of British Columbia. The author has contributed to research in topics: Drug resistance & Saccharomyces cerevisiae. The author has an hindex of 5, co-authored 8 publications receiving 168 citations. Previous affiliations of Lai Hong Wong include University of Edinburgh.
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Journal ArticleDOI
Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids
Visesato Mor,Antonella Rella,Amir M. Farnoud,Ashutosh Singh,Mansa Munshi,Arielle M. Bryan,Shamoon Naseem,James B. Konopka,Iwao Ojima,Erika E. Büllesbach,Alan Ashbaugh,Michael J. Linke,Michael J. Linke,Melanie T. Cushion,Melanie T. Cushion,Margaret S. Collins,Hari Krishna Ananthula,Larry Sallans,Pankaj B. Desai,Nathan P. Wiederhold,Annette W. Fothergill,William R. Kirkpatrick,Thomas F. Patterson,Lai Hong Wong,Sunita Sinha,Guri Giaever,Corey Nislow,Patrick Flaherty,Xuewen Pan,Gabriele Vargas Cesar,Patricia de Melo Tavares,Susana Frases,Kildare Miranda,Kildare Miranda,Marcio L. Rodrigues,Marcio L. Rodrigues,Chiara Luberto,Leonardo Nimrichter,Maurizio Del Poeta +38 more
TL;DR: Two compounds found were highly effective in vitro and in vivo against several pathogenic fungi and were well tolerated by animals and additive to current antifungals, suggesting that these drugs might pave the way for the development of a new class of antIFungals.
Journal ArticleDOI
Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress.
Antoine Simoneau,Étienne Ricard,Sandra Weber,Ian Hammond-Martel,Lai Hong Wong,Adnane Sellam,Guri Giaever,Corey Nislow,Martine Raymond,Hugo Wurtele +9 more
TL;DR: The data support the concept that chromosome-wide histone deacetylation by sirtuins is critical to mitigate growth defects caused by endogenous genotoxins, and cause yeast to solicit specific DNA damage response pathways for survival.
Journal ArticleDOI
A yeast chemical genetic screen identifies inhibitors of human telomerase.
Lai Hong Wong,Asier Unciti-Broceta,Michaela Spitzer,R. L. White,Mike Tyers,Mike Tyers,Lea Harrington,Lea Harrington +7 more
TL;DR: A surrogate yeast high-throughput assay to identify human telomerase inhibitors was developed, and four of eight compounds identified reproducibly restored growth to strains expressing active human telomersase, and three of these four compounds also specifically inhibited purified human telomeres in vitro.
Journal ArticleDOI
Erratum for Mor et al., "Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids".
Visesato Mor,Antonella Rella,Amir M. Farnoud,Ashutosh Singh,Mansa Munshi,Arielle M. Bryan,Shamoon Naseem,James B. Konopka,Iwao Ojima,Erika E. Büllesbach,Alan Ashbaugh,Michael J. Linke,Melanie T. Cushion,Margaret S. Collins,Hari Krishna Ananthula,Larry Sallans,Pankaj B. Desai,Nathan P. Wiederhold,Annette W. Fothergill,William R. Kirkpatrick,Thomas F. Patterson,Lai Hong Wong,Sunita Sinha,Guri Giaever,Corey Nislow,Patrick Flaherty,Xuewen Pan,Gabriele Vargas Cesar,Patricia de Melo Tavares,Susana Frases,Kildare Miranda,Kildare Miranda,Marcio L. Rodrigues,Marcio L. Rodrigues,Chiara Luberto,Leonardo Nimrichter,Maurizio Del Poeta +36 more
TL;DR: Visesato Mor, a Antonella Rella, a Amir M. Farnoud, a Ashutosh Singh, a Mansa Munshi, a Arielle Bryan, a Shamoon Naseem, a James B. Konopka, a Iwao Ojima,b Erika Bullesbach,c Alan Ashbaugh,d Michael J. Linke, d,e Melanie Cushion,d,e Margaret Collins,e Hari Krishna Ananthula,
Journal ArticleDOI
Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions.
Lai Hong Wong,Sunita Sinha,Julien R. C. Bergeron,Joseph C. Mellor,Guri Giaever,Patrick Flaherty,Corey Nislow +6 more
TL;DR: An integrative functional variomics methodology combining deep sequencing and a Bayesian statistical model is reported to provide a comprehensive list of drug resistance alleles from complex variant populations.