M
Maurizio Del Poeta
Researcher at Stony Brook University
Publications - 14
Citations - 420
Maurizio Del Poeta is an academic researcher from Stony Brook University. The author has contributed to research in topics: Cryptococcosis & Cryptococcus neoformans. The author has an hindex of 8, co-authored 14 publications receiving 292 citations. Previous affiliations of Maurizio Del Poeta include Veterans Health Administration & United States Department of Veterans Affairs.
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Journal ArticleDOI
Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids
Visesato Mor,Antonella Rella,Amir M. Farnoud,Ashutosh Singh,Mansa Munshi,Arielle M. Bryan,Shamoon Naseem,James B. Konopka,Iwao Ojima,Erika E. Büllesbach,Alan Ashbaugh,Michael J. Linke,Michael J. Linke,Melanie T. Cushion,Melanie T. Cushion,Margaret S. Collins,Hari Krishna Ananthula,Larry Sallans,Pankaj B. Desai,Nathan P. Wiederhold,Annette W. Fothergill,William R. Kirkpatrick,Thomas F. Patterson,Lai Hong Wong,Sunita Sinha,Guri Giaever,Corey Nislow,Patrick Flaherty,Xuewen Pan,Gabriele Vargas Cesar,Patricia de Melo Tavares,Susana Frases,Kildare Miranda,Kildare Miranda,Marcio L. Rodrigues,Marcio L. Rodrigues,Chiara Luberto,Leonardo Nimrichter,Maurizio Del Poeta +38 more
TL;DR: Two compounds found were highly effective in vitro and in vivo against several pathogenic fungi and were well tolerated by animals and additive to current antifungals, suggesting that these drugs might pave the way for the development of a new class of antIFungals.
Journal ArticleDOI
Sphingosine-1-phosphate receptors and innate immunity.
TL;DR: This review will summarise current understanding of S1P signalling, focusing on recent novel findings in the roles of S 1P receptors in innate immunity.
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Synthesis and Biological Properties of Fungal Glucosylceramide
TL;DR: Present in many fungi, including yeasts, molds, and in dimorphic fungi, fungal glucosylceramide exhibits a characteristic structure synthesized by fungal specific enzymes, and is envisioned as an important fungal target for compounds with specific and broad-spectrum activity.
Journal ArticleDOI
The Granuloma Response Controlling Cryptococcosis in Mice Depends on the Sphingosine Kinase 1-Sphingosine 1-Phosphate Pathway.
TL;DR: Results suggest that the SK1-S1P pathway promotes host defense against C. neoformans infections by regulating cytokine levels, promoting extracellular killing by phagocytes, and generating a granulomatous response.
Journal ArticleDOI
FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages.
Arielle M. Bryan,Jeehyun Karen You,Travis J. McQuiston,Cristina Lazzarini,Zhijuan Qiu,Brian S. Sheridan,Barbara Nuesslein-Hildesheim,Maurizio Del Poeta,Maurizio Del Poeta +8 more
TL;DR: It is suggested that FTY720 reactivates cryptococcosis from the granuloma through a S1P receptor 3-mediated mechanism and support the rationale for development of more specific receptor modulators for therapeutic use of MS.