Assia Derfoul

TL;DR: It is reported that during the transition from quiescence to proliferation, skeletal muscle stem cells experience a metabolic switch from fatty acid oxidation to glycolysis, revealing how metabolic cues can be mechanistically translated into epigenetic modifications that regulate skeletal muscle cell biology.

TL;DR: The data suggest that eRNAs contribute to establishing a cell-type-specific transcriptional circuitry by directing chromatin-remodeling events by regulating genomic access of the transcriptional complex to defined regulatory regions.

TL;DR: It is reported that EZH2, the enzymatic subunit of the Polycomb-repressive complex 2 (PRC2), is expressed in both Pax7+/Myf5⁻ stem cells and Pax7/My f5+ committed myogenic precursors and is required for homeostasis of the adult SC pool.

TL;DR: It is suggested that GlcN treatment enhances hMSC chondrogenesis and maintains cartilage matrix gene expression in chondrocytes, which may account for some of the reported chONDroprotective properties of Glcn on cartilage.

TL;DR: Findings indicate that reduced miR-214 levels may contribute to breast tumorigenesis by allowing abnormally elevated Ezh2 accumulation and subsequent unchecked cell proliferation and invasion.