S
Stefania Dell'Orso
Researcher at National Institutes of Health
Publications - 38
Citations - 2568
Stefania Dell'Orso is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 17, co-authored 25 publications receiving 1606 citations. Previous affiliations of Stefania Dell'Orso include United States Department of Energy Office of Science.
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Journal ArticleDOI
The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells
James G. Ryall,Stefania Dell'Orso,Assia Derfoul,Aster H. Juan,Hossein Zare,Xuesong Feng,Daphney Clermont,Miroslav Koulnis,Gustavo Gutierrez-Cruz,Marcella Fulco,Vittorio Sartorelli +10 more
TL;DR: It is reported that during the transition from quiescence to proliferation, skeletal muscle stem cells experience a metabolic switch from fatty acid oxidation to glycolysis, revealing how metabolic cues can be mechanistically translated into epigenetic modifications that regulate skeletal muscle cell biology.
Journal ArticleDOI
Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.
David B. Beck,Marcela A. Ferrada,Keith A. Sikora,Amanda K. Ombrello,Jason C. Collins,Wuhong Pei,Nicholas Balanda,Daron L. Ross,Daniela Ospina Cardona,Zhijie Wu,Bhavisha A Patel,Kalpana Manthiram,Emma M. Groarke,Fernanda Gutierrez-Rodrigues,Patrycja Hoffmann,Sofia Rosenzweig,Shuichiro Nakabo,Laura W. Dillon,Christopher S. Hourigan,Wanxia L. Tsai,Sarthak Gupta,Carmelo Carmona-Rivera,Anthony J. Asmar,Lisha Xu,Hirotsugu Oda,Wendy Goodspeed,Karyl S. Barron,Michele Nehrebecky,Anne Jones,Ryan S. Laird,Natalie Deuitch,Dorota Rowczenio,Emily Rominger,Kristina V. Wells,Chyi-Chia Richard Lee,Weixin Wang,Megan Trick,James C. Mullikin,Gustaf Wigerblad,Stephen R. Brooks,Stefania Dell'Orso,Zuoming Deng,Jae Jin Chae,Alina Dulau-Florea,May Christine V. Malicdan,Danica Novacic,Robert A. Colbert,Mariana J. Kaplan,Massimo Gadina,Sinisa Savic,Helen J. Lachmann,Mones Abu-Asab,Benjamin D. Solomon,Kyle Retterer,William A. Gahl,Shawn M. Burgess,Ivona Aksentijevich,Neal S. Young,Katherine R. Calvo,Achim Werner,Daniel L. Kastner,Peter C. Grayson +61 more
TL;DR: Using a genotype-driven approach, this disorder is identified that connects seemingly unrelated adult-onset inflammatory syndromes and is named the VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome.
Journal ArticleDOI
eRNAs Promote Transcription by Establishing Chromatin Accessibility at Defined Genomic Loci
Kambiz Mousavi,Hossein Zare,Stefania Dell'Orso,Lars Grøntved,Gustavo Gutierrez-Cruz,Assia Derfoul,Gordon L. Hager,Vittorio Sartorelli +7 more
TL;DR: The data suggest that eRNAs contribute to establishing a cell-type-specific transcriptional circuitry by directing chromatin-remodeling events by regulating genomic access of the transcriptional complex to defined regulatory regions.
Journal ArticleDOI
Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells
Aster H. Juan,Assia Derfoul,Xuesong Feng,James G. Ryall,Stefania Dell'Orso,Alessandra Pasut,Hossein Zare,James M. Simone,Michael A. Rudnicki,Vittorio Sartorelli +9 more
TL;DR: It is reported that EZH2, the enzymatic subunit of the Polycomb-repressive complex 2 (PRC2), is expressed in both Pax7+/Myf5⁻ stem cells and Pax7/My f5+ committed myogenic precursors and is required for homeostasis of the adult SC pool.
Journal ArticleDOI
Single cell analysis of adult mouse skeletal muscle stem cells in homeostatic and regenerative conditions
Stefania Dell'Orso,Aster H. Juan,Kyung-Dae Ko,Faiza Naz,Jelena Perovanovic,Gustavo Gutierrez-Cruz,Xuesong Feng,Vittorio Sartorelli +7 more
TL;DR: Single cell RNA sequencing of adult muscle stem cells and primary myoblasts from homeostatic or regenerating muscles identifies distinct clusters of cell types with partially overlapping but distinct transcriptional signatures.