H
Hossein Zare
Researcher at Johns Hopkins University
Publications - 150
Citations - 4175
Hossein Zare is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cognition & Health care. The author has an hindex of 23, co-authored 135 publications receiving 3204 citations. Previous affiliations of Hossein Zare include National Institutes of Health & University of Maryland, Baltimore.
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Journal ArticleDOI
The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells
James G. Ryall,Stefania Dell'Orso,Assia Derfoul,Aster H. Juan,Hossein Zare,Xuesong Feng,Daphney Clermont,Miroslav Koulnis,Gustavo Gutierrez-Cruz,Marcella Fulco,Vittorio Sartorelli +10 more
TL;DR: It is reported that during the transition from quiescence to proliferation, skeletal muscle stem cells experience a metabolic switch from fatty acid oxidation to glycolysis, revealing how metabolic cues can be mechanistically translated into epigenetic modifications that regulate skeletal muscle cell biology.
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eRNAs Promote Transcription by Establishing Chromatin Accessibility at Defined Genomic Loci
Kambiz Mousavi,Hossein Zare,Stefania Dell'Orso,Lars Grøntved,Gustavo Gutierrez-Cruz,Assia Derfoul,Gordon L. Hager,Vittorio Sartorelli +7 more
TL;DR: The data suggest that eRNAs contribute to establishing a cell-type-specific transcriptional circuitry by directing chromatin-remodeling events by regulating genomic access of the transcriptional complex to defined regulatory regions.
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BACH2 represses effector programs to stabilize T reg -mediated immune homeostasis
Rahul Roychoudhuri,Kiyoshi Hirahara,Kiyoshi Hirahara,Kambiz Mousavi,David Clever,Christopher A. Klebanoff,Michael Bonelli,Giuseppe Sciumè,Hossein Zare,Golnaz Vahedi,Barbara Dema,Zhiya Yu,Hui Liu,Hayato Takahashi,Mahadev Rao,Pawel Muranski,Joseph G. Crompton,George A. Punkosdy,Davide Bedognetti,Ena Wang,Victoria Hoffmann,Juan Rivera,Francesco M. Marincola,Atsushi Nakamura,Vittorio Sartorelli,Yuka Kanno,Luca Gattinoni,Akihiko Muto,Kazuhiko Igarashi,John J. O'Shea,Nicholas P. Restifo +30 more
TL;DR: Findings identify BACH2 as a key regulator of CD4+ T-cell differentiation that prevents inflammatory disease by controlling the balance between tolerance and immunity.
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Interactome Maps of Mouse Gene Regulatory Domains Reveal Basic Principles of Transcriptional Regulation
Kyong-Rim Kieffer-Kwon,Zhonghui Tang,Ewy Mathé,Jason Qian,Myong-Hee Sung,Guoliang Li,Wolfgang Resch,Songjoon Baek,Nathanael Pruett,Lars Grøntved,Laura Vian,Steevenson Nelson,Hossein Zare,Ofir Hakim,Deepak Reyon,Arito Yamane,Hirotaka Nakahashi,Alexander L. Kovalchuk,Jizhong Zou,J. Keith Joung,Vittorio Sartorelli,Chia-Lin Wei,Xiaoan Ruan,Gordon L. Hager,Yijun Ruan,Rafael Casellas +25 more
TL;DR: It is demonstrated that the turning on and off of enhancers during development correlates with promoter activity, and proposed that organisms rely on a dynamic enhancer landscape to control basic cellular functions in a tissue-specific manner.
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Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease
Carmine Spampanato,Erin J. Feeney,Lishu Li,Monica Cardone,Jeong-A Lim,Fabio Annunziata,Hossein Zare,Roman S. Polishchuk,Rosa Puertollano,Giancarlo Parenti,Andrea Ballabio,Nina Raben +11 more
TL;DR: It is shown that TFEB is a viable therapeutic target in PD: overexpression of T FEB in a new muscle cell culture system and in mouse models of the disease reduced glycogen load and lysosomal size, improved autophagosome processing, and alleviated excessive accumulation of autophagic vacuoles.