A
Astrid Hagelkruys
Researcher at Austrian Academy of Sciences
Publications - 38
Citations - 2536
Astrid Hagelkruys is an academic researcher from Austrian Academy of Sciences. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 11, co-authored 23 publications receiving 1774 citations. Previous affiliations of Astrid Hagelkruys include Medical University of Vienna.
Papers
More filters
Journal ArticleDOI
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.
Vanessa Monteil,Hyesoo Kwon,Patrícia Rezende do Prado,Astrid Hagelkruys,Reiner A. Wimmer,Martin Stahl,Alexandra Leopoldi,Elena Garreta,Carmen Hurtado del Pozo,Felipe Prosper,Juan P. Romero,Gerald Wirnsberger,Haibo Zhang,Arthur S. Slutsky,Ryan K. Conder,Nuria Montserrat,Ali Mirazimi,Ali Mirazimi,Josef M. Penninger,Josef M. Penninger +19 more
TL;DR: It is demonstrated that hrsACE2 can significantly block early stages of SARS-CoV-2 infections, and is proposed that inhibiting this interaction might be used in treating patients with COVID-19.
Book ChapterDOI
The Biology of HDAC in Cancer: The Nuclear and Epigenetic Components
TL;DR: This chapter summarizes the current state of knowledge of individual nuclear HDAC family members in development and tumorigenesis, their contribution to the hallmarks of cancer, and the involvement of HDACfamily members in different types of human malignancies.
Journal ArticleDOI
Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis.
Jennifer Jurkin,Gordin Zupkovitz,Sabine Lagger,Reinhard Grausenburger,Astrid Hagelkruys,Lukas Kenner,Christian Seiser +6 more
TL;DR: New findings on redundant and unique functions ofHDAC1 and HDAC2 as regulators of proliferation and tumorigenesis are discussed and potential implications for applications of HDAC inhibitors as therapeutic drugs are discussed.
Journal ArticleDOI
Transcription and beyond: the role of mammalian class I lysine deacetylases.
TL;DR: Simultaneous ablation of HDAC1 and HDAC2 or single deletion of Hdac3 severely impairs cell cycle progression in all proliferating cell types indicating that these class I deacetylases are promising targets for small molecule inhibitors as anti-tumor drugs.
Journal ArticleDOI
A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog
Astrid Hagelkruys,Sabine Lagger,Julia Krahmer,Alexandra Leopoldi,Matthias Artaker,Oliver Pusch,Jürgen Zezula,Simon Weissmann,Yunli Xie,Christian Schöfer,Michaela Schlederer,Gerald Brosch,Patrick Matthias,Jim Selfridge,Hans Lassmann,Jürgen A. Knoblich,Christian Seiser +16 more
TL;DR: The data indicate that HDAC1 and HDAC2 have a common function in maintaining proper chromatin structures and show that Hdac2 has a unique role by controlling the fate of neural progenitors during normal brain development.