C
Carmen Hurtado del Pozo
Researcher at University of Barcelona
Publications - 6
Citations - 2106
Carmen Hurtado del Pozo is an academic researcher from University of Barcelona. The author has contributed to research in topics: Receptor & Kidney disease. The author has an hindex of 5, co-authored 6 publications receiving 1392 citations. Previous affiliations of Carmen Hurtado del Pozo include Catalan Institution for Research and Advanced Studies.
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Journal ArticleDOI
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.
Vanessa Monteil,Hyesoo Kwon,Patrícia Rezende do Prado,Astrid Hagelkruys,Reiner A. Wimmer,Martin Stahl,Alexandra Leopoldi,Elena Garreta,Carmen Hurtado del Pozo,Felipe Prosper,Juan P. Romero,Gerald Wirnsberger,Haibo Zhang,Arthur S. Slutsky,Ryan K. Conder,Nuria Montserrat,Ali Mirazimi,Ali Mirazimi,Josef M. Penninger,Josef M. Penninger +19 more
TL;DR: It is demonstrated that hrsACE2 can significantly block early stages of SARS-CoV-2 infections, and is proposed that inhibiting this interaction might be used in treating patients with COVID-19.
Journal ArticleDOI
Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells.
Elena Garreta,Patrícia Rezende do Prado,Carolina Tarantino,Roger Oria,Lucia Fanlo,Elisa Martí,Dobryna Zalvidea,Xavier Trepat,Pere Roca-Cusachs,Aleix Gavaldà-Navarro,Luca Cozzuto,Josep M. Campistol,Juan Carlos Izpisua Belmonte,Carmen Hurtado del Pozo,Nuria Montserrat +14 more
TL;DR: A method to accelerate the generation of kidney organoids from human pluripotent stem cells cultured in a three-dimensional environment and exposed to inductive stimuli has been developed, with the organoids capable of recapitulating kidney organogenesis.
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Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection.
Vanessa Monteil,Matheus Dyczynski,Volker M. Lauschke,Hyesoo Kwon,Gerald Wirnsberger,Sonia Youhanna,Haibo Zhang,Arthur S. Slutsky,Carmen Hurtado del Pozo,Moritz Horn,Nuria Montserrat,Josef M. Penninger,Josef M. Penninger,Ali Mirazimi,Ali Mirazimi +14 more
TL;DR: The data provided here demonstrate that combining two therapeutic modalities with different targets, common strategy in HIV treatment, exhibit strong additive effects at sub‐toxic concentrations, and lay the groundwork for the study of combinatorial regimens in future COVID‐19 clinical trials.
Journal ArticleDOI
The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation
Poonam Dhillon,Jihwan Park,Jihwan Park,Carmen Hurtado del Pozo,Lingzhi Li,Tomohito Doke,Shizheng Huang,Juanjuan Zhao,Hyun Mi Kang,Hyun Mi Kang,Rojesh Shrestra,Michael S. Balzer,Shatakshee Chatterjee,Patrícia Rezende do Prado,Seung Yub Han,Hongbo Liu,Xin Sheng,Pieterjan Dierickx,Kirill Batmanov,Juan P. Romero,Felipe Prosper,Mingyao Li,Liming Pei,Liming Pei,Junhyong Kim,Nuria Montserrat,Katalin Susztak +26 more
TL;DR: Through unbiased cell trajectory analyses, it is shown that PT cell differentiation is altered in kidney disease, and proximal tubule (PT) cells are identified as the key vulnerable cell type.
Journal ArticleDOI
Modeling epigenetic modifications in renal development and disease with organoids and genome editing
TL;DR: An overview on how epigenetic processes are altered in kidney development and disease is provided, and how CRISPR-modified kidney organoids can help to understand the function of epigenetic marks is discussed.