A
Astrid Hagelkruys
Researcher at Austrian Academy of Sciences
Publications - 38
Citations - 2536
Astrid Hagelkruys is an academic researcher from Austrian Academy of Sciences. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 11, co-authored 23 publications receiving 1774 citations. Previous affiliations of Astrid Hagelkruys include Medical University of Vienna.
Papers
More filters
Journal ArticleDOI
Identification of ALK in Thinness
Michael Orthofer,Armand Valsesia,Reedik Mägi,Qiao-Ping Wang,Joanna Kaczanowska,Ivona Kozieradzki,Alexandra Leopoldi,Domagoj Cikes,Lydia M. Zopf,Evgenii O. Tretiakov,Egon Demetz,Richard Hilbe,Anna Boehm,Melita Ticevic,Margit Nõukas,Alexander Jais,Katrin Spirk,Teleri Clark,Sabine Amann,Maarja Lepamets,Christoph Neumayr,Cosmas D. Arnold,Zhengchao Dou,Volker Kuhn,Maria Novatchkova,Shane J. F. Cronin,Uwe J. F. Tietge,Uwe J. F. Tietge,Simone Müller,J. Andrew Pospisilik,Vanja Nagy,Chi-chung Hui,Jelena Lazovic,Harald Esterbauer,Astrid Hagelkruys,Ivan Tancevski,Florian W. Kiefer,Tibor Harkany,Wulf Haubensak,G. Gregory Neely,Andres Metspalu,Jörg Hager,Nele Gheldof,Josef M. Penninger,Josef M. Penninger +44 more
TL;DR: This work performed a GWAS on metabolically healthy thin individuals (lowest 6th percentile of the population-wide BMI spectrum) in a uniquely phenotyped Estonian cohort and discovered anaplastic lymphoma kinase (ALK) as a candidate thinness gene.
Journal ArticleDOI
Epigenetic Regulation of a Murine Retrotransposon by a Dual Histone Modification Mark
Reinhard Brunmeir,Sabine Lagger,Elisabeth Simboeck,Anna Sawicka,Gerda Egger,Astrid Hagelkruys,Yu Zhang,Patrick Matthias,Wolfgang J. Miller,Christian Seiser +9 more
TL;DR: It is proposed that activation of a specific mobile element is linked to a dual epigenetic mark and proposed a model whereby phosphoacetylation of histone H3 is crucial for full transcriptional activation of VL30 elements.
Journal ArticleDOI
Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans
Sabine Lagger,Dominique Meunier,Mario Mikula,Reinhard Brunmeir,Michaela Schlederer,Matthias Artaker,Oliver Pusch,Gerda Egger,Astrid Hagelkruys,Wolfgang Mikulits,Georg Weitzer,Ernst W Muellner,Martin Susani,Lukas Kenner,Christian Seiser +14 more
TL;DR: A novel role for HDAC1 in the control of tumour proliferation is revealed andHDAC1 is identified as a potential marker for benign teratomas.
Journal ArticleDOI
HDAC1 and HDAC2 Regulate Intermediate Progenitor Positioning to Safeguard Neocortical Development.
Tianxiang Tang,Yandong Zhang,Yafei Wang,Zheping Cai,Zhiheng Lu,Leiting Li,Ru Huang,Astrid Hagelkruys,Patrick Matthias,Heng Zhang,Christian Seiser,Yunli Xie +11 more
TL;DR: It is demonstrated that spatial control of IP positioning is essential for neocortical development and that HDAC1 and HDAC2 regulate the spatial positioning of IPs to form the SVZ.
Journal ArticleDOI
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells
Elena Garreta,Patricia Prado,Megan L. Stanifer,Vanessa Monteil,Andres Marco,Asier Ullate-Agote,Daniel Moya-Rull,Amaia Vilas-Zornoza,Carolina Tarantino,Juan Pablo Romero,Gustav Jonsson,Roger Oria,Alexandra Leopoldi,Astrid Hagelkruys,Maria Gallo,Federico Gonzalez,P. Domingo-Pedrol,Aleix Gavaldà,Carmen Hurtado del Pozo,O. Hasan Ali,Pedro Ventura-Aguiar,Josep M. Campistol,Felipe Prosper,Ali Mirazimi,Steeve Boulant,Josef M. Penninger,Nuria Montserrat +26 more
TL;DR: In this article , the authors established a human kidney organoid model promoting early hallmarks of diabetic kidney disease development and found that diabetic-like kidney organoids exhibited higher viral loads compared with their control counterparts.