G
Gerald Wirnsberger
Researcher at Austrian Academy of Sciences
Publications - 35
Citations - 4855
Gerald Wirnsberger is an academic researcher from Austrian Academy of Sciences. The author has contributed to research in topics: Medicine & T cell. The author has an hindex of 18, co-authored 30 publications receiving 3848 citations. Previous affiliations of Gerald Wirnsberger include University of Salzburg & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.
Vanessa Monteil,Hyesoo Kwon,Patrícia Rezende do Prado,Astrid Hagelkruys,Reiner A. Wimmer,Martin Stahl,Alexandra Leopoldi,Elena Garreta,Carmen Hurtado del Pozo,Felipe Prosper,Juan P. Romero,Gerald Wirnsberger,Haibo Zhang,Arthur S. Slutsky,Ryan K. Conder,Nuria Montserrat,Ali Mirazimi,Ali Mirazimi,Josef M. Penninger,Josef M. Penninger +19 more
TL;DR: It is demonstrated that hrsACE2 can significantly block early stages of SARS-CoV-2 infections, and is proposed that inhibiting this interaction might be used in treating patients with COVID-19.
Journal ArticleDOI
Antigen presentation in the thymus for positive selection and central tolerance induction
TL;DR: New discoveries pertaining to cortex-specific pathways of antigen processing, the heterogeneity of thymic dendritic cells and the intercellular transfer of self antigens have uncovered surprising and unique aspects of antigen presentation in the Thymic microenvironment are discussed.
Journal ArticleDOI
A dual role for autophagy in a murine model of lung cancer
Shuan Rao,Luigi Tortola,Thomas Perlot,Gerald Wirnsberger,Maria Novatchkova,Roberto Nitsch,Peter Sykacek,Lukas Frank,Daniel Schramek,Vukoslav Komnenovic,Verena Sigl,Karin Aumayr,Gerald Schmauss,Nicole Fellner,Stephan Handschuh,Martin Glösmann,Pawel Pasierbek,Michaela Schlederer,Guenter P. Resch,Yuting Ma,Yuting Ma,Yuting Ma,Heng Yang,Heng Yang,Heng Yang,Helmuth Popper,Lukas Kenner,Guido Kroemer,Josef M. Penninger +28 more
TL;DR: Tissue-specific inactivation of Atg5, essential for the formation of autophagosomes, markedly impairs the progression of KRas(G12D)-driven lung cancer, resulting in a significant survival advantage of tumour-bearing mice, suggesting a link between deregulated autophagy and regulatory T cell controlled anticancer immunity.
Journal ArticleDOI
Seventy-five genetic loci influencing the human red blood cell
Pim van der Harst,Weihua Zhang,Irene Mateo Leach,Augusto Rendon,Niek Verweij,Joban Sehmi,Dirk S. Paul,Ulrich Elling,Hooman Allayee,Xinzhong Li,Aparna Radhakrishnan,Sian Tsung Tan,Katrin Voss,Christian X. Weichenberger,Cornelis A. Albers,Abtehale Al-Hussani,Folkert W. Asselbergs,Marina Ciullo,Fabrice Danjou,Christian Dina,Tõnu Esko,David M. Evans,Lude Franke,Martin Gögele,Jaana Hartiala,Micha Hersch,Hilma Holm,Jouke-Jan Hottenga,Stavroula Kanoni,Marcus E. Kleber,Vasiliki Lagou,Claudia Langenberg,Lorna M. Lopez,Leo-Pekka Lyytikäinen,Olle Melander,Federico Murgia,Ilja M. Nolte,Paul F. O'Reilly,Sandosh Padmanabhan,Afshin Parsa,Nicola Pirastu,Eleonora Porcu,Laura Portas,Inga Prokopenko,Janina S. Ried,So-Youn Shin,Clara S. Tang,Alexander Teumer,Michela Traglia,Sheila Ulivi,Harm-Jan Westra,Jian Yang,Jing Hua Zhao,Franco Anni,Abdel Abdellaoui,Antony P. Attwood,Beverley Balkau,Stefania Bandinelli,François Bastardot,Beben Benyamin,Bernhard O. Boehm,William O.C.M. Cookson,Debashish Das,Paul I.W. de Bakker,Rudolf A. de Boer,Eco J. C. de Geus,Marleen H. M. de Moor,Maria Dimitriou,Francisco S. Domingues,Angela Döring,Gunnar Engström,Gudmundur I. Eyjolfsson,Luigi Ferrucci,Krista Fischer,Renzo Galanello,Stephen F. Garner,Bernd Genser,Quince Gibson,Giorgia Girotto,Daniel F. Gudbjartsson,Sarah E. Harris,Anna-Liisa Hartikainen,Claire E. Hastie,Bo Hedblad,Thomas Illig,Jennifer Jolley,Mika Kähönen,Ido P. Kema,John P. Kemp,Liming Liang,Heather Lloyd-Jones,Ruth J. F. Loos,Stuart Meacham,Sarah E. Medland,Christa Meisinger,Yasin Memari,Evelin Mihailov,Kathy Miller,Miriam F. Moffatt,Matthias Nauck,Maria Novatchkova,Teresa Nutile,Isleifur Olafsson,Pall T. Onundarson,Debora Parracciani,Brenda W.J.H. Penninx,Lucia Perseu,Antonio Piga,Giorgio Pistis,Anneli Pouta,Ursula Puc,Olli T. Raitakari,Susan M. Ring,Antonietta Robino,Daniela Ruggiero,Aimo Ruokonen,Aude Saint-Pierre,Cinzia Sala,Andres Salumets,Jennifer G. Sambrook,Hein Schepers,Carsten Oliver Schmidt,Herman H W Silljé,Robert Sladek,Johannes H. Smit,John M. Starr,Jonathan Stephens,Patrick Sulem,Toshiko Tanaka,Unnur Thorsteinsdottir,Vinicius Tragante,Wiek H. van Gilst,L. Joost van Pelt,Dirk J. van Veldhuisen,Uwe Völker,John Whitfield,Gonneke Willemsen,Bernhard R. Winkelmann,Gerald Wirnsberger,Ale Algra,Francesco Cucca,Adamo Pio D'Adamo,John Danesh,Ian J. Deary,Anna F. Dominiczak,Paul Elliott,Paolo Fortina,Philippe Froguel,Paolo Gasparini,Andreas Greinacher,Stanley L. Hazen,Marjo-Riitta Järvelin,Kay-Tee Khaw,Terho Lehtimäki,Winfried Maerz,Nicholas G. Martin,Andres Metspalu,Braxton D. Mitchell,Grant W. Montgomery,Carmel Moore,Gerjan Navis,Mario Pirastu,Peter P. Pramstaller,Ramiro Ramirez-Solis,Eric E. Schadt,James Scott,Alan R. Shuldiner,George Davey Smith,J. Gustav Smith,Harold Snieder,Rossella Sorice,Tim D. Spector,Kari Stefansson,Michael Stumvoll,W.H. Wilson Tang,Daniela Toniolo,Anke Tönjes,Peter M. Visscher,Peter Vollenweider,Nicholas J. Wareham,Bruce H. R. Wolffenbuttel,Dorret I. Boomsma,Jacques S. Beckmann,George Dedoussis,Panos Deloukas,Manuel A. R. Ferreira,Serena Sanna,Manuela Uda,Andrew A. Hicks,Josef M. Penninger,Christian Gieger,Jaspal S. Kooner,Willem H. Ouwehand,Nicole Soranzo,John C. Chambers +194 more
TL;DR: A genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals identifies 75 independent genetic loci associated with one or more red blood cell phenotypes at P < 10−8, which together explain 4–9% of the phenotypic variance per trait.
Seventy-five genetic loci influencing the human red blood cell
Pim van der Harst,Weihua Zhang,Irene Mateo Leach,Augusto Rendon,Niek Verweij,Joban Sehmi,Dirk S. Paul,Ulrich Elling,Hooman Allayee,Xinzhong Li,Aparna Radhakrishnan,Sian-Tsung Tan,Katrin Voss,Christian X. Weichenberger,Cornelis A. Albers,Abtehale Al-Hussani,Folkert W. Asselbergs,Marina Ciullo,Fabrice Danjou,Christian Dina,Tõnu Esko,David M. Evans,Lude Franke,Martin Goegele,Jaana Hartiala,Micha Hersch,Hilma Holm,Jouke-Jan Hottenga,Stavroula Kanoni,Marcus E. Kleber,Vasiliki Lagou,Claudia Langenberg,Lorna M. Lopez,Leo-Pekka Lyytikäinen,Olle Melander,Federico Murgia,Ilja M. Nolte,Paul F. O'Reilly,Sandosh Padmanabhan,Afshin Parsa,Nicola Pirastu,Eleonora Porcu,Laura Portas,Inga Prokopenko,Janina S. Ried,So-Youn Shin,Clara S. Tang,Alexander Teumer,Michela Traglia,Sheila Ulivi,Harm-Jan Westra,Jian Yang,Jing Hua Zhao,Franco Anni,Abdel Abdellaoui,Antony P. Attwood,Beverley Balkau,Stefania Bandinelli,François Bastardot,Beben Benyamin,Bernhard O. Boehm,William O.C.M. Cookson,Debashish Das,Paul I.W. de Bakker,Rudolf A. de Boer,Eco J. C. de Geus,Marleen H.M. de Moor,Maria Dimitriou,Francisco S. Domingues,Angela Doering,Gunnar Engström,Gudmundur I. Eyjolfsson,Luigi Ferrucci,Krista Fischer,Renzo Galanello,Stephen F. Garner,Bernd Genser,Quince Gibson,Giorgia Girotto,Daniel F. Gudbjartsson,Sarah E. Harris,Anna-Liisa Hartikainen,Claire E. Hastie,Bo Hedblad,Thomas Illig,Jennifer Jolley,Mika Kähönen,Ido P. Kema,John P. Kemp,Liming Liang,Heather Lloyd-Jones,Ruth J. F. Loos,Stuart Meacham,Sarah E. Medland,Christa Meisinger,Yasin Memari,Evelin Mihailov,Kathy Miller,Miriam F. Moffatt,Matthias Nauck,Maria Novatchkova,Teresa Nutile,Isleifur Olafsson,Pall T. Onundarson,Debora Parracciani,Brenda W.J.H. Penninx,Lucia Perseu,Antonio Piga,Giorgio Pistis,Anneli Pouta,Ursula Puc,Olli T. Raitakari,Susan M. Ring,Antonietta Robino,Daniela Ruggiero,Aimo Ruokonen,Aude Saint-Pierre,Cinzia Sala,Andres Salumets,Jennifer G. Sambrook,Hein Schepers,Carsten Oliver Schmidt,Herman H W Silljé,Robert Sladek,Johannes H. Smit,John M. Starr,Jonathan Stephens,Patrick Sulem,Toshiko Tanaka,Unnur Thorsteinsdottir,Vinicius Tragante,Wiek H. van Gilst,L. Joost van Pelt,Dirk J. van Veldhuisen,Uwe Voelker,John Whitfield,Gonneke Willemsen,Bernhard R. Winkelmann,Gerald Wirnsberger,Ale Algra,Francesco Cucca,Adamo Pio d'Adamo,John Danesh,Ian J. Deary,Anna F. Dominiczak,Paul Elliott,Paolo Fortina,Philippe Froguel,Paolo Gasparini,Andreas Greinacher,Stanley L. Hazen,Marjo-Riitta Järvelin,Kay-Tee Khaw,Terho Lehtimäki,Winfried Maerz,Nicholas G. Martin,Andres Metspalu,Braxton D. Mitchell,Grant W. Montgomery,Carmel Moore,Gerjan Navis,Mario Pirastu,Peter P. Pramstaller,Ramiro Ramirez-Solis,Eric E. Schadt,James Scott,Alan R. Shuldiner,George Davey Smith,J. Gustav Smith,Harold Snieder,Rossella Sorice,Tim D. Spector,Kari Stefansson,Michael Stumvoll,W.H. Wilson Tang,Daniela Toniolo,Anke Toenjes,Peter M. Visscher,Peter Vollenweider,Nicholas J. Wareham,Bruce H. R. Wolffenbuttel,Dorret I. Boomsma,Jacques S. Beckmann,George Dedoussis,Panos Deloukas,Manuel A. R. Ferreira,Serena Sanna,Manuela Uda,Andrew A. Hicks,Josef M. Penninger,Christian Gieger,Jaspal S. Kooner,Willem H. Ouwehand,Nicole Soranzo,John C. Chambers +194 more
TL;DR: In this article, the authors carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals and identified 75 independent genetic loci associated with one or more red blood cell phenotypes at P < 10−8, which together explain 4-9% of the phenotypic variance per trait.