A
Astrid Magenau
Researcher at Garvan Institute of Medical Research
Publications - 51
Citations - 3302
Astrid Magenau is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Lipid raft & Membrane. The author has an hindex of 29, co-authored 49 publications receiving 2889 citations. Previous affiliations of Astrid Magenau include University of New South Wales.
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Journal ArticleDOI
Quantitative imaging of membrane lipid order in cells and organisms
TL;DR: A quantitative fluorescence microscopy technique for imaging localized lipid environments and measuring membrane lipid order in live and fixed cells, as well as in intact tissues, is described.
Journal ArticleDOI
Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events
David Williamson,Dylan M. Owen,Jérémie Rossy,Astrid Magenau,Matthias Wehrmann,J. Justin Gooding,Katharina Gaus +6 more
TL;DR: Using super-resolution fluorescence microscopy, data suggest that TCR ligation preconditions the membrane for vesicle recruitment and bulk activation of the Lat signaling network.
Journal ArticleDOI
PALM imaging and cluster analysis of protein heterogeneity at the cell surface
Dylan M. Owen,Carles Rentero,Jérémie Rossy,Astrid Magenau,David Williamson,Macarena Rodriguez,Katharina Gaus +6 more
TL;DR: The authors employed photoactivatable localization microscopy and direct stochastic optical reconstruction microscopy (dSTORM) imaging and image analysis based on Ripley's K ‐function to quantify the distribution and heterogeneity of proteins at the cell plasma membrane.
Journal ArticleDOI
Sub-resolution lipid domains exist in the plasma membrane and regulate protein diffusion and distribution
TL;DR: This work provides the first direct evidence that the plasma membrane of intact, live cells is comprised of a sub-resolution mixture of approximately 76% ordered and 24% disordered lipid domains, which correspond to liquid-ordered and -disordered model membranes.
Journal ArticleDOI
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis
Claire Vennin,Claire Vennin,Venessa T. Chin,Venessa T. Chin,Sean C. Warren,Sean C. Warren,Morghan C. Lucas,Morghan C. Lucas,David Herrmann,David Herrmann,Astrid Magenau,Astrid Magenau,Pauline Mélénec,Pauline Mélénec,Stacey N. Walters,Stacey N. Walters,Gonzalo del Monte-Nieto,Gonzalo del Monte-Nieto,James R.W. Conway,James R.W. Conway,Max Nobis,Max Nobis,Amr H. Allam,Amr H. Allam,Rachael A. McCloy,Rachael A. McCloy,Nicola Currey,Nicola Currey,Mark Pinese,Mark Pinese,Alice Boulghourjian,Anaiis Zaratzian,Arne A. S. Adam,Celine Heu,Adnan Nagrial,Angela Chou,Angela Chou,Angela Chou,Angela Steinmann,Alison Drury,Danielle Froio,Marc Giry-Laterriere,Marc Giry-Laterriere,Nathanial L. E. Harris,Nathanial L. E. Harris,Tri Giang Phan,Tri Giang Phan,Rohit Jain,Wolfgang Weninger,Wolfgang Weninger,Ewan J. McGhee,Renee Whan,Amber L. Johns,Jaswinder S. Samra,Lorraine A. Chantrill,Lorraine A. Chantrill,Anthony J. Gill,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Richard P. Harvey,Richard P. Harvey,Andrew V. Biankin,Andrew V. Biankin,T.R. Jeffry Evans,Kurt I. Anderson,Shane T. Grey,Shane T. Grey,Christopher J. Ormandy,Christopher J. Ormandy,David Gallego-Ortega,David Gallego-Ortega,Yingxiao Wang,Michael S. Samuel,Owen J. Sansom,Andrew Burgess,Andrew Burgess,Thomas R. Cox,Thomas R. Cox,Jennifer P. Morton,Marina Pajic,Marina Pajic,Paul Timpson,Paul Timpson +83 more
TL;DR: A graded response to priming is demonstrated in stratified patient-derived tumors, indicating that fine-tuned tissue manipulation before chemotherapy may offer opportunities in both primary and metastatic targeting of pancreatic cancer.