M
Marc Giry-Laterriere
Researcher at Garvan Institute of Medical Research
Publications - 13
Citations - 5114
Marc Giry-Laterriere is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Pancreatic cancer & Wnt signaling pathway. The author has an hindex of 11, co-authored 13 publications receiving 3979 citations. Previous affiliations of Marc Giry-Laterriere include University of New South Wales.
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Journal ArticleDOI
Genomic analyses identify molecular subtypes of pancreatic cancer
Peter Bailey,David K. Chang,Katia Nones,Katia Nones,Amber L. Johns,Ann-Marie Patch,Ann-Marie Patch,Marie-Claude Gingras,David Miller,David Miller,Angelika N. Christ,Timothy J. C. Bruxner,Michael C.J. Quinn,Michael C.J. Quinn,Craig Nourse,Craig Nourse,Murtaugh Lc,Ivon Harliwong,Senel Idrisoglu,Suzanne Manning,Ehsan Nourbakhsh,Shivangi Wani,Shivangi Wani,J. Lynn Fink,Oliver Holmes,Oliver Holmes,Chin,Matthew J. Anderson,Stephen H. Kazakoff,Stephen H. Kazakoff,Conrad Leonard,Conrad Leonard,Felicity Newell,Nicola Waddell,Scott Wood,Scott Wood,Qinying Xu,Qinying Xu,Peter J. Wilson,Nicole Cloonan,Nicole Cloonan,Karin S. Kassahn,Karin S. Kassahn,Karin S. Kassahn,Darrin Taylor,Kelly Quek,Alan J. Robertson,Lorena Pantano,Laura Mincarelli,Luis Navarro Sanchez,Lisa Evers,Jianmin Wu,Mark Pinese,Mark J. Cowley,Jones,Jones,Emily K. Colvin,Adnan Nagrial,Emily S. Humphrey,Lorraine A. Chantrill,Lorraine A. Chantrill,Amanda Mawson,Jeremy L. Humphris,Angela Chou,Angela Chou,Marina Pajic,Marina Pajic,Christopher J. Scarlett,Christopher J. Scarlett,Andreia V. Pinho,Marc Giry-Laterriere,Ilse Rooman,Jaswinder S. Samra,James G. Kench,James G. Kench,James G. Kench,Jessica A. Lovell,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Kim Moran-Jones,Nigel B. Jamieson,Janet Graham,Janet Graham,Fraser Duthie,Karin A. Oien,Karin A. Oien,Hair J,Robert Grützmann,Anirban Maitra,Christine A. Iacobuzio-Donahue,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Corbo,Claudio Bassi,Borislav Rusev,Paola Capelli,Roberto Salvia,Giampaolo Tortora,Debabrata Mukhopadhyay,Gloria M. Petersen,Munzy Dm,William E. Fisher,Saadia A. Karim,Eshleman,Ralph H. Hruban,Christian Pilarsky,Jennifer P. Morton,Owen J. Sansom,Aldo Scarpa,Elizabeth A. Musgrove,Ulla-Maja Bailey,Oliver Hofmann,Oliver Hofmann,R. L. Sutherland,David A. Wheeler,Anthony J. Gill,Anthony J. Gill,Richard A. Gibbs,John V. Pearson,John V. Pearson,Andrew V. Biankin,Sean M. Grimmond,Sean M. Grimmond,Sean M. Grimmond +128 more
TL;DR: Detailed genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/SLIT signalling, G1/S transition, SWI-SNF, chromatin modification, DNA repair and RNA processing.
Journal ArticleDOI
Whole genomes redefine the mutational landscape of pancreatic cancer.
Nicola Waddell,Marina Pajic,Ann-Marie Patch,David K. Chang,Karin S. Kassahn,Peter Bailey,Amber L. Johns,David Miller,Katia Nones,Kelly Quek,Michael C.J. Quinn,Alan J. Robertson,Muhammad Zaki Hidayatullah Fadlullah,Timothy J. C. Bruxner,Angelika N. Christ,Ivon Harliwong,Senel Idrisoglu,Suzanne Manning,Craig Nourse,Ehsan Nourbakhsh,Shivangi Wani,Peter J. Wilson,Emma Markham,Nicole Cloonan,Matthew J. Anderson,J. Lynn Fink,Oliver Holmes,Stephen H. Kazakoff,Conrad Leonard,Felicity Newell,Barsha Poudel,Sarah Song,Darrin Taylor,Nick Waddell,Scott Wood,Qinying Xu,Jianmin Wu,Mark Pinese,Mark J. Cowley,Hong C. Lee,Marc D. Jones,Adnan Nagrial,Jeremy L. Humphris,Lorraine A. Chantrill,Venessa T. Chin,Angela Steinmann,Amanda Mawson,Emily S. Humphrey,Emily K. Colvin,Angela Chou,Christopher J. Scarlett,Andreia V. Pinho,Marc Giry-Laterriere,Ilse Rooman,Jaswinder S. Samra,James G. Kench,Jessica A. Pettitt,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Nigel B. Jamieson,Janet Graham,Simone P. Niclou,Rolf Bjerkvig,Robert Grützmann,Daniela Aust,Ralph H. Hruban,Anirban Maitra,Christine A. Iacobuzio-Donahue,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Vincenzo Corbo,Claudio Bassi,Massimo Falconi,Giuseppe Zamboni,Giampaolo Tortora,Margaret A. Tempero,Anthony J. Gill,James R. Eshleman,Christian Pilarsky,Aldo Scarpa,Elizabeth A. Musgrove,John V. Pearson,Andrew V. Biankin,Sean M. Grimmond +88 more
TL;DR: Genomic instability co-segregated with inactivation of DNA maintenance genes (BRCA1, BRCA2 or PALB2) and a mutational signature of DNA damage repair deficiency, and 4 of 5 individuals with these measures of defective DNA maintenance responded to platinum therapy.
Journal ArticleDOI
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis
Claire Vennin,Claire Vennin,Venessa T. Chin,Venessa T. Chin,Sean C. Warren,Sean C. Warren,Morghan C. Lucas,Morghan C. Lucas,David Herrmann,David Herrmann,Astrid Magenau,Astrid Magenau,Pauline Mélénec,Pauline Mélénec,Stacey N. Walters,Stacey N. Walters,Gonzalo del Monte-Nieto,Gonzalo del Monte-Nieto,James R.W. Conway,James R.W. Conway,Max Nobis,Max Nobis,Amr H. Allam,Amr H. Allam,Rachael A. McCloy,Rachael A. McCloy,Nicola Currey,Nicola Currey,Mark Pinese,Mark Pinese,Alice Boulghourjian,Anaiis Zaratzian,Arne A. S. Adam,Celine Heu,Adnan Nagrial,Angela Chou,Angela Chou,Angela Chou,Angela Steinmann,Alison Drury,Danielle Froio,Marc Giry-Laterriere,Marc Giry-Laterriere,Nathanial L. E. Harris,Nathanial L. E. Harris,Tri Giang Phan,Tri Giang Phan,Rohit Jain,Wolfgang Weninger,Wolfgang Weninger,Ewan J. McGhee,Renee Whan,Amber L. Johns,Jaswinder S. Samra,Lorraine A. Chantrill,Lorraine A. Chantrill,Anthony J. Gill,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Richard P. Harvey,Richard P. Harvey,Andrew V. Biankin,Andrew V. Biankin,T.R. Jeffry Evans,Kurt I. Anderson,Shane T. Grey,Shane T. Grey,Christopher J. Ormandy,Christopher J. Ormandy,David Gallego-Ortega,David Gallego-Ortega,Yingxiao Wang,Michael S. Samuel,Owen J. Sansom,Andrew Burgess,Andrew Burgess,Thomas R. Cox,Thomas R. Cox,Jennifer P. Morton,Marina Pajic,Marina Pajic,Paul Timpson,Paul Timpson +83 more
TL;DR: A graded response to priming is demonstrated in stratified patient-derived tumors, indicating that fine-tuned tissue manipulation before chemotherapy may offer opportunities in both primary and metastatic targeting of pancreatic cancer.
Journal ArticleDOI
Hypermutation In Pancreatic Cancer
Jeremy L. Humphris,Ann-Marie Patch,Ann-Marie Patch,Katia Nones,Katia Nones,Peter Bailey,Peter Bailey,Amber L. Johns,Skye McKay,David K. Chang,David Miller,David Miller,Marina Pajic,Marina Pajic,Karin S. Kassahn,Karin S. Kassahn,Michael C.J. Quinn,Michael C.J. Quinn,Timothy J. C. Bruxner,Angelika N. Christ,Ivon Harliwong,Senel Idrisoglu,Suzanne Manning,Craig Nourse,Craig Nourse,Ehsan Nourbakhsh,Andrew Stone,Peter J. Wilson,Matthew J. Anderson,J. Lynn Fink,Oliver Holmes,Oliver Holmes,Stephen H. Kazakoff,Stephen H. Kazakoff,Conrad Leonard,Conrad Leonard,Felicity Newell,Felicity Newell,Nick Waddell,Scott Wood,Scott Wood,Ronald S Mead,Qinying Xu,Qinying Xu,Jianmin Wu,Mark Pinese,Mark J. Cowley,Mark J. Cowley,Marc D. Jones,Marc D. Jones,Adnan Nagrial,Venessa T. Chin,Lorraine A. Chantrill,Lorraine A. Chantrill,Amanda Mawson,Angela Chou,Angela Chou,Christopher J. Scarlett,Christopher J. Scarlett,Andreia V. Pinho,Ilse Rooman,Marc Giry-Laterriere,Jaswinder S. Samra,Jaswinder S. Samra,James G. Kench,James G. Kench,James G. Kench,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Nigel B. Jamieson,Nigel B. Jamieson,Colin J. McKay,C. Ross Carter,Euan J. Dickson,Janet Graham,Janet Graham,Fraser Duthie,Karin A. Oien,Jane Hair,Jennifer P. Morton,Owen J. Sansom,Robert Grützmann,Ralph H. Hruban,Anirban Maitra,Christine A. Iacobuzio-Donahue,Richard D. Schulick,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Borislav Rusev,Vincenzo Corbo,Roberto Salvia,Ivana Cataldo,Giampaolo Tortora,Margaret A. Tempero,Oliver Hofmann,James R. Eshleman,Christian Pilarsky,Aldo Scarpa,Elizabeth A. Musgrove,Elizabeth A. Musgrove,Elizabeth A. Musgrove,Anthony J. Gill,Anthony J. Gill,Anthony J. Gill,John V. Pearson,John V. Pearson,Sean M. Grimmond,Sean M. Grimmond,Nicola Waddell,Nicola Waddell,Andrew V. Biankin +115 more
TL;DR: Defining mutation load in individual pancreatic cancers and the optimal assay for patient selection may inform clinical trial design for immunotherapy in pancreatic cancer.
Journal ArticleDOI
SOX9 regulates ERBB signalling in pancreatic cancer development
Adrien Grimont,Andreia Av Pinho,Mark Cowley,Cécile Augereau,Amanda Mawson,Marc Giry-Laterriere,Geraldine Van den Steen,Nicola Waddell,Marina Pajic,Christine Sempoux,Jianmin Wu,Sean M. Grimmond,Andrew V. Biankin,Frédéric P. Lemaigre,Ilse Rooman,Patrick Jacquemin +15 more
TL;DR: By integrating data from patient samples and mouse models, this work found that SOX9 regulates the ERBB pathway throughout pancreatic tumourigenesis, which opens perspectives for therapy targeting tumoursigenic mechanisms.