C
Claire Vennin
Researcher at Netherlands Cancer Institute
Publications - 15
Citations - 887
Claire Vennin is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Pancreatic cancer & Metastasis. The author has an hindex of 9, co-authored 15 publications receiving 568 citations. Previous affiliations of Claire Vennin include University of New South Wales & Garvan Institute of Medical Research.
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Journal ArticleDOI
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis
Claire Vennin,Claire Vennin,Venessa T. Chin,Venessa T. Chin,Sean C. Warren,Sean C. Warren,Morghan C. Lucas,Morghan C. Lucas,David Herrmann,David Herrmann,Astrid Magenau,Astrid Magenau,Pauline Mélénec,Pauline Mélénec,Stacey N. Walters,Stacey N. Walters,Gonzalo del Monte-Nieto,Gonzalo del Monte-Nieto,James R.W. Conway,James R.W. Conway,Max Nobis,Max Nobis,Amr H. Allam,Amr H. Allam,Rachael A. McCloy,Rachael A. McCloy,Nicola Currey,Nicola Currey,Mark Pinese,Mark Pinese,Alice Boulghourjian,Anaiis Zaratzian,Arne A. S. Adam,Celine Heu,Adnan Nagrial,Angela Chou,Angela Chou,Angela Chou,Angela Steinmann,Alison Drury,Danielle Froio,Marc Giry-Laterriere,Marc Giry-Laterriere,Nathanial L. E. Harris,Nathanial L. E. Harris,Tri Giang Phan,Tri Giang Phan,Rohit Jain,Wolfgang Weninger,Wolfgang Weninger,Ewan J. McGhee,Renee Whan,Amber L. Johns,Jaswinder S. Samra,Lorraine A. Chantrill,Lorraine A. Chantrill,Anthony J. Gill,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Richard P. Harvey,Richard P. Harvey,Andrew V. Biankin,Andrew V. Biankin,T.R. Jeffry Evans,Kurt I. Anderson,Shane T. Grey,Shane T. Grey,Christopher J. Ormandy,Christopher J. Ormandy,David Gallego-Ortega,David Gallego-Ortega,Yingxiao Wang,Michael S. Samuel,Owen J. Sansom,Andrew Burgess,Andrew Burgess,Thomas R. Cox,Thomas R. Cox,Jennifer P. Morton,Marina Pajic,Marina Pajic,Paul Timpson,Paul Timpson +83 more
TL;DR: A graded response to priming is demonstrated in stratified patient-derived tumors, indicating that fine-tuned tissue manipulation before chemotherapy may offer opportunities in both primary and metastatic targeting of pancreatic cancer.
Journal ArticleDOI
CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer.
Brooke A. Pereira,Claire Vennin,Michael Papanicolaou,Cecilia R. Chambers,Cecilia R. Chambers,David Herrmann,David Herrmann,Jennifer P. Morton,Thomas R. Cox,Thomas R. Cox,Paul Timpson,Paul Timpson +11 more
TL;DR: This review explores how different aspects of CAF heterogeneity are defined and how these manifest in multiple cancers, with a focus on pancreatic ductal adenocarcinoma (PDAC).
Journal ArticleDOI
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
Claire Vennin,Claire Vennin,Claire Vennin,Pauline Mélénec,Pauline Mélénec,Romain Rouet,Romain Rouet,Max Nobis,Max Nobis,Aurélie Cazet,Aurélie Cazet,Kendelle J. Murphy,Kendelle J. Murphy,David Herrmann,David Herrmann,Daniel A Reed,Daniel A Reed,Morghan C. Lucas,Morghan C. Lucas,Sean C. Warren,Sean C. Warren,Zehra Elgundi,Mark Pinese,Mark Pinese,Gabriella Kalna,Daniel L. Roden,Daniel L. Roden,Monisha Samuel,Anaiis Zaratzian,Shane T. Grey,Shane T. Grey,Andrew M. Da Silva,Wilfred Leung,Wilfred Leung,Wilfred Leung,Australian Pancreatic Genome Initiative,Suresh Mathivanan,Yingxiao Wang,Anthony W Braithwaite,Anthony W Braithwaite,Daniel Christ,Daniel Christ,Aleš Benda,Ashleigh Parkin,Ashleigh Parkin,Phoebe A. Phillips,John M. Whitelock,Anthony J. Gill,Owen J. Sansom,David R. Croucher,David R. Croucher,Benjamin L. Parker,Marina Pajic,Marina Pajic,Jennifer P. Morton,Thomas R. Cox,Thomas R. Cox,Paul Timpson,Paul Timpson +58 more
TL;DR: It is revealed that depleting perlecan in the stroma combined with chemotherapy prolongs mouse survival, supporting it as a potential target for anti-stromal therapies in pancreatic cancer and identifying perle can as a mediator of the pro-metastatic environment.
Journal ArticleDOI
SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer
N L E Harris,N L E Harris,Claire Vennin,Claire Vennin,James R.W. Conway,James R.W. Conway,Kara L. Vine,Kara L. Vine,Mark Pinese,Mark J. Cowley,Robert F. Shearer,Robert F. Shearer,Morghan C. Lucas,Morghan C. Lucas,David Herrmann,David Herrmann,Amr H. Allam,Marina Pajic,Marina Pajic,Jennifer P. Morton,Andrew V. Biankin,Marie Ranson,Marie Ranson,Paul Timpson,Paul Timpson,Darren N. Saunders,Darren N. Saunders +26 more
TL;DR: A novel role for SerpinB2 in theStromal compartment in PDAC invasion through regulation of stromal remodelling is established and the SerpinsB2/uPA axis is highlighted for further investigation as a potential therapeutic target in pancreatic cancer.
Journal ArticleDOI
CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer.
Murugan Kalimutho,Murugan Kalimutho,Debottam Sinha,Debottam Sinha,Jessie Jeffery,Katia Nones,Katia Nones,Sriganesh Srihari,Winnie Fernando,Pascal H.G. Duijf,Claire Vennin,Claire Vennin,Prahlad V. Raninga,Devathri Nanayakkara,Deepak Mittal,Jodi M. Saunus,Jodi M. Saunus,Sunil R. Lakhani,Sunil R. Lakhani,J. Alejandro Lopez,J. Alejandro Lopez,Kevin J. Spring,Kevin J. Spring,Kevin J. Spring,Paul Timpson,Paul Timpson,Brian Gabrielli,Nicola Waddell,Kum Kum Khanna +28 more
TL;DR: High CEP55 levels dictate cell fate during perturbed mitosis, and forced mitotic cell death by blocking MEK1/2‐PLK1 represents a potential therapeutic strategy for MYC‐CEP55‐dependent basal‐like, triple‐negative breast cancers.