A
Audrey Leloire
Researcher at Centre national de la recherche scientifique
Publications - 12
Citations - 1172
Audrey Leloire is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Adipose tissue & Type 2 diabetes. The author has an hindex of 10, co-authored 10 publications receiving 980 citations. Previous affiliations of Audrey Leloire include university of lille.
Papers
More filters
Journal ArticleDOI
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
Atsuhiko Ichimura,Akira Hirasawa,Odile Poulain-Godefroy,Odile Poulain-Godefroy,Amélie Bonnefond,Amélie Bonnefond,Takafumi Hara,Loic Yengo,Loic Yengo,Ikuo Kimura,Audrey Leloire,Audrey Leloire,Ning Liu,Keiko Iida,Hélène Choquet,Hélène Choquet,Philippe Besnard,Cécile Lecoeur,Cécile Lecoeur,Sidonie Vivequin,Sidonie Vivequin,Kumiko Ayukawa,Masato Takeuchi,Kentaro Ozawa,Maithé Tauber,Claudio Maffeis,Anita Morandi,Anita Morandi,Raffaella Buzzetti,Paul Elliott,Anneli Pouta,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Antje Körner,Wieland Kiess,Marie Pigeyre,Roberto Caiazzo,Wim Van Hul,Luc Van Gaal,Fritz F. Horber,Beverley Balkau,Claire Levy-Marchal,Konstantinos Rouskas,Konstantinos Rouskas,Konstantinos Rouskas,Anastasia Kouvatsi,Johannes Hebebrand,Anke Hinney,André Scherag,François Pattou,David Meyre,David Meyre,David Meyre,Taka-aki Koshimizu,Isabelle Wolowczuk,Isabelle Wolowczuk,Gozoh Tsujimoto,Philippe Froguel,Philippe Froguel,Philippe Froguel +59 more
TL;DR: This study demonstrates that the lipid sensor GPR120 has a key role in sensing dietary fat and, therefore, in the control of energy balance in both humans and rodents.
Journal ArticleDOI
The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation.
Marie Favennec,Benjamin Hennart,Robert Caiazzo,Audrey Leloire,Loic Yengo,Marie Verbanck,Abdelilah Arredouani,Michel Marre,Marie Pigeyre,Alban Bessede,Gilles J. Guillemin,Giulia Chinetti,Bart Staels,François Pattou,Beverley Balkau,Delphine Allorge,Philippe Froguel,Odile Poulain-Godefroy +17 more
TL;DR: This study characterized the kynurenine pathway (KP) in human obesity by evaluating circulating levels of kynuranines and the expression of KP enzymes in adipose tissue.
Journal ArticleDOI
Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone
Isabelle Wolowczuk,Benjamin Hennart,Audrey Leloire,Alban Bessede,M. Soichot,Solenne Taront,Robert Caiazzo,Violeta Raverdy,Marie Pigeyre,Gilles J. Guillemin,Delphine Allorge,François Pattou,Philippe Froguel,Philippe Froguel,Odile Poulain-Godefroy +14 more
TL;DR: Indoleamine 2,3-dioxygenase-1 activation represents a local compensatory mechanism to limit obesity-induced inflammation and hypertension.
CALL FOR PAPERS Integrative and Translational Physiology: Inflammation and Immunity in Organ System Physiology Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone
Isabelle Wolowczuk,Benjamin Hennart,Audrey Leloire,Alban Bessede,M. Soichot,Solenne Taront,R. Caiazzo,Violeta Raverdy,Marie Pigeyre,Gilles J. Guillemin,Delphine Allorge,François Pattou,Philippe Froguel,Odile Poulain-Godefroy,Recherche Médicale,Wolowczuk I,Benjamin Hennart,Audrey Leloire,Bessede A,M Soichot,Taront S,Robert Caiazzo,François Pattou,P. Froguel +23 more
Journal ArticleDOI
Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes.
Amar Abderrahmani,Loic Yengo,Robert Caiazzo,Mickaël Canouil,Stéphane Cauchi,Violeta Raverdy,Valérie Plaisance,Valérie Pawlowski,Stéphane Lobbens,Julie Maillet,Laure Rolland,Raphael Boutry,Gurvan Queniat,Maxime Kwapich,Mathie Tenenbaum,Julien Bricambert,Sophie Saussenthaler,Elodie Anthony,Pooja Jha,Julien Derop,Olivier Sand,Iandry Rabearivelo,Audrey Leloire,Marie Pigeyre,Martine Daujat-Chavanieu,Sabine Gerbal-Chaloin,Tasnim Dayeh,Guillaume Lassailly,Philippe Mathurin,Bart Staels,Johan Auwerx,Annette Schürmann,Catherine Postic,Clemens Schafmayer,Jochen Hampe,Amélie Bonnefond,François Pattou,Philippe Froguel +37 more
TL;DR: Using DNA methylome and transcriptome analyses of livers from obese individuals, this paper found that hypomethylation at a CpG site in PDGFA (encoding platelet-derived growth factor α) and increased PDGF-AA secretion contributes to insulin resistance, opening new therapeutic avenues against Type 2 diabetes and possibly NAFLD.