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Austin B. Tomaney
Researcher at Pacific Biosciences
Publications - 11
Citations - 3804
Austin B. Tomaney is an academic researcher from Pacific Biosciences. The author has contributed to research in topics: Nucleic acid & Signal. The author has an hindex of 6, co-authored 11 publications receiving 3627 citations.
Papers
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Journal ArticleDOI
Real-Time DNA Sequencing from Single Polymerase Molecules
John Eid,Adrian Fehr,Jeremy Gray,Khai Luong,John Lyle,Geoff Otto,Paul Peluso,David R. Rank,Primo Baybayan,Brad Bettman,Arkadiusz Bibillo,Keith Bjornson,Bidhan Chaudhuri,Fred Christians,Ronald L. Cicero,Sonya Clark,Ravindra V. Dalal,Alex DeWinter,John Dixon,Mathieu Foquet,Alfred Gaertner,Paul Hardenbol,Cheryl Heiner,Kevin Hester,David P. Holden,Gregory J. Kearns,Xiangxu Kong,Ronald Kuse,Yves Lacroix,Steven Lin,Paul Lundquist,Congcong Ma,Patrick Marks,Mark Maxham,Devon Murphy,Insil Park,Thang Pham,Michael Phillips,Joy Roy,Robert Sebra,Gene Shen,Jon M. Sorenson,Austin B. Tomaney,Kevin Travers,Mark Trulson,John Vieceli,Jeffrey Wegener,Dawn Wu,Alicia Yang,Denis Zaccarin,Peter Zhao,Frank Zhong,Jonas Korlach,Stephen Turner +53 more
TL;DR: Single-molecule, real-time sequencing data obtained from a DNA polymerase performing uninterrupted template-directed synthesis using four distinguishable fluorescently labeled deoxyribonucleoside triphosphates (dNTPs) are presented.
Journal ArticleDOI
Parallel confocal detection of single molecules in real time
Paul Lundquist,Cheng F Zhong,Peiqian Zhao,Austin B. Tomaney,Paul Peluso,John Dixon,Brad Bettman,Yves Lacroix,Kwo Deborah Pao-Tung,Etienne McCullough,Mark Maxham,Kevin Hester,Paul McNitt,Donald M Grey,Carlos Henriquez,Mathieu Foquet,Stephen Turner,Denis Zaccarin +17 more
TL;DR: The confocal detection principle is extended to a highly parallel optical system that continuously analyzes thousands of concurrent sample locations and is demonstrated to detect and identify single fluorescent molecules from each of several thousand independent confocal volumes in real time.
Patent
Methods and processes for calling bases in sequence by incorporation methods
Kenneth Mark Maxham,Devon Murphy,David P. Holden,Kevin Hester,Patrick Marks,Austin B. Tomaney +5 more
TL;DR: In this article, the authors describe a sequence-by-incorporation (SBI) method for processing signal data from analytical operations and systems, and particularly in processing data from sequence by incorporation processes to identify nucleotide sequences of template nucleic acids.
Patent
Classification of nucleic acid templates
Benjamin Flusberg,Jonas Korlach,Jeffrey Wegener,Tyson A. Clark,Igor D. Vilfan,Andrey Kislyuk,Stephen Turner,Jon M. Sorenson,Kevin Travers,Cheryl Heiner,Austin B. Tomaney,Patrick Marks,Jessica Lee,Lei Jia,Dale R. Webster,John Lyle,Jeremiah Hanes,Joseph D. Puglisi +17 more
TL;DR: In this article, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. But these methods are not suitable for the characterization of nucleic acids.
Patent
Analytical systems and methods with software mask
Cheng Frank Zhong,Austin B. Tomaney,Patrick Marks,Stuart George Johnson,James N. Labrenz,Paul Lundquist +5 more
TL;DR: In this article, the authors define and apply a 2-dimensional software mask for obtaining signal data from arrays with higher signal to noise than where the mask is not applied, and apply it to arrays of sequence-by-incorporation processes to identify nucleotide sequences.