B. de Kruijff

TL;DR: The possible functional roles of lipids are reviewed in terms of previous models such as the fluid mosaic model of Singer and Nicolson or the earlier unit membrane model so that the requirement for an alternative approach becomes apparent.

TL;DR: It is shown that vancomycin and the antibacterial peptide nisin Z use the same target: the membrane-anchored cell wall precursor Lipid II, thus causing the peptide to be highly active (in the nanomolar range).

TL;DR: Genetically engineered nisin variants are used to identify the structural requirements for the interaction of the peptide with lipid II, and the remaining in vivo activity is found to result from the unaltered capacity of the mutated peptide to bind to lipid II and thus to inhibit its incorporation into the peptidoglycan network.

TL;DR: Mechanisms of the polyene antibiotic induced permeability changes in membranes are proposed based on the analysis of the complexes of cholesterol, amphotericin B, nystatin, etruscomycin and pimaricin, which can be built with space-filling models.

TL;DR: The polymorphic phase behavior of aqueous dispersions of phosphatidylethanolamines isolated from human erythrocytes, hen egg yolk and Escherichia coli have been investigated employing 31P NMR techniques as mentioned in this paper.