R
Rowena Eakins
Researcher at University of Liverpool
Publications - 3
Citations - 1331
Rowena Eakins is an academic researcher from University of Liverpool. The author has contributed to research in topics: Liver X receptor & Hepatic stellate cell. The author has an hindex of 3, co-authored 3 publications receiving 1173 citations.
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy,Nicola J. Hewitt,Ute Albrecht,Melvin E. Andersen,Nariman Ansari,Sudin Bhattacharya,Johannes G. Bode,Jennifer Bolleyn,Christoph Borner,J Böttger,Albert Braeuning,Robert A. Budinsky,Britta Burkhardt,Neil R. Cameron,Giovanni Camussi,Chong Su Cho,Yun Jaie Choi,J. Craig Rowlands,Uta Dahmen,Georg Damm,Olaf Dirsch,María Teresa Donato,Jian Dong,Steven Dooley,Dirk Drasdo,Dirk Drasdo,Dirk Drasdo,Rowena Eakins,Karine Sá Ferreira,Valentina Fonsato,Joanna Fraczek,Rolf Gebhardt,Andrew Gibson,Matthias Glanemann,Christopher E. Goldring,María José Gómez-Lechón,Geny M. M. Groothuis,Lena Gustavsson,Christelle Guyot,David Hallifax,Seddik Hammad,Adam S. Hayward,Dieter Häussinger,Claus Hellerbrand,Philip Hewitt,Stefan Hoehme,Hermann-Georg Holzhütter,J. Brian Houston,Jens Hrach,Kiyomi Ito,Hartmut Jaeschke,Verena Keitel,Jens M. Kelm,B. Kevin Park,Claus Kordes,Gerd A. Kullak-Ublick,Edward L. LeCluyse,Peng Lu,Jennifer Luebke-Wheeler,Anna Lutz,Daniel J. Maltman,Madlen Matz-Soja,Patrick D. McMullen,Irmgard Merfort,Simon Messner,Christoph Meyer,Jessica Mwinyi,Dean J. Naisbitt,Andreas K. Nussler,Peter Olinga,Francesco Pampaloni,Jingbo Pi,Linda J. Pluta,Stefan Przyborski,Anup Ramachandran,Vera Rogiers,Cliff Rowe,Celine Schelcher,Kathrin Schmich,Michael Schwarz,Bijay Singh,Ernst H. K. Stelzer,Bruno Stieger,Regina Stöber,Yuichi Sugiyama,Ciro Tetta,Wolfgang E. Thasler,Tamara Vanhaecke,Mathieu Vinken,Thomas S. Weiss,Agata Widera,Courtney G. Woods,Jinghai James Xu,Kathy Yarborough,Jan G. Hengstler +94 more
TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
Journal ArticleDOI
Assessing the Safety of Stem Cell Therapeutics
Christopher E. Goldring,Paul A. Duffy,Nissim Benvenisty,Nissim Benvenisty,Peter W. Andrews,Uri Ben-David,Rowena Eakins,Neil French,Neil A. Hanley,Lorna Kelly,Neil R. Kitteringham,Jens Kurth,Deborah Ladenheim,Hugh Laverty,James W. McBlane,Gopalan Narayanan,Sara Patel,Jens Reinhardt,Annamaria Rossi,Michaela Sharpe,B. Kevin Park +20 more
TL;DR: The safety issues pertaining to novel stem cell-derived treatments are set out, knowledge gaps that require further research are identified, and a roadmap for developing safety assessment criteria is suggested.
Journal ArticleDOI
Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome
Rowena Eakins,Joanne Walsh,Laura E. Randle,Rosalind E. Jenkins,Ina Schuppe-Koistinen,Cliff Rowe,P.J. Starkey Lewis,O Vasieva,Neus Prats,Nathalie Brillant,Mariona Aulí,Matthew B. Bayliss,Steven D. Webb,JA Rees,Neil R. Kitteringham,Christopher E. Goldring,B.K. Park +16 more
TL;DR: It is shown that adaptation to acetaminophen has a spatial component, involving a shift in regionalisation of CYP2E1, which may prevent toxicity thresholds being reached and reveal unexpected complexity and dynamic behaviour in the biological response to drug-induced liver injury.