S
Szun S. Tay
Researcher at University of New South Wales
Publications - 48
Citations - 2605
Szun S. Tay is an academic researcher from University of New South Wales. The author has contributed to research in topics: Cytotoxic T cell & Immune system. The author has an hindex of 22, co-authored 45 publications receiving 2137 citations. Previous affiliations of Szun S. Tay include Children's Medical Research Institute & Alfred Hospital.
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Journal ArticleDOI
Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells
Ben Roediger,Ryan Kyle,Kwok Ho Yip,Nital Sumaria,Nital Sumaria,Thomas V. Guy,Brian S. Kim,Andrew J. Mitchell,Szun S. Tay,Rohit Jain,Elizabeth Forbes-Blom,Xi Chen,Philip L. Tong,Philip L. Tong,Philip L. Tong,Holly A. Bolton,David Artis,William E. Paul,Barbara Fazekas de St Groth,Barbara Fazekas de St Groth,Michele A. Grimbaldeston,Graham Le Gros,Wolfgang Weninger,Wolfgang Weninger,Wolfgang Weninger +24 more
TL;DR: The data show that ILC2 cells have both pro- and anti-inflammatory properties and identify a previously unknown interactive pathway between two innate populations of cells of the immune system linked to type 2 immunity and allergic diseases.
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Liver-Resident Memory CD8 + T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.
Daniel Fernandez-Ruiz,Wei Yi Ng,Wei Yi Ng,Lauren E. Holz,Joel Z. Ma,Ali Zaid,Yik Chun Wong,Lei Shong Lau,Vanessa Mollard,Anton Cozijnsen,Nicholas Collins,Jessica Li,Jessica Li,Gayle M. Davey,Yu Kato,Sapna Devi,Roghieh Skandari,Michael Pauley,Jonathan H. Manton,Dale I. Godfrey,Asolina Braun,Szun S. Tay,Peck Szee Tan,Peck Szee Tan,David G. Bowen,Friedrich Koch-Nolte,Björn Rissiek,Francis R. Carbone,Brendan S. Crabb,Mireille H. Lahoud,Mireille H. Lahoud,Ian A. Cockburn,Scott N. Mueller,Patrick Bertolino,Geoffrey I. McFadden,Irina Caminschi,Irina Caminschi,William R. Heath +37 more
TL;DR: It is shown that by combining dendritic cell-targeted priming with liver inflammation and antigen recognition on hepatocytes, high frequencies of Trm cells could be induced and these cells were essential for protection against malaria sporozoite challenge.
Journal ArticleDOI
Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves.
Puspa Batten,Padmini Sarathchandra,Joseph W. Antoniw,Szun S. Tay,Mark W. Lowdell,Patricia M. Taylor,Magdi H. Yacoub +6 more
TL;DR: Human bone marrow-derived mesenchymal stem cells (MSCs) are reported as a suitable allogeneic cell source for tissue-engineered heart valves and downregulate T cell responses through direct contact and secretion of anti-inflammatory and tolerogenic cytokines, which may involve the recruitment of regulatory T cells.
Journal ArticleDOI
Hepatocyte entry leads to degradation of autoreactive CD8 T cells
Volker Benseler,Alessandra Warren,Michelle Vo,Lauren E. Holz,Szun S. Tay,David G. Le Couteur,Eamon Breen,Anthony C. Allison,Nico van Rooijen,Claire McGuffog,Hans J. Schlitt,David G. Bowen,Geoffrey W. McCaughan,Patrick Bertolino +13 more
TL;DR: This work identifies a unique mechanism of peripheral deletion in which naïve autoreactive CD8 T cells are rapidly eliminated in the liver after intrahepatic activation, and proposes that this “suicidal emperipolesis” is aunique mechanism of autore active T-cell deletion, a process critical for the maintenance of tolerance.
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A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment
Frederic Sierro,Maximilien Evrard,Simone Rizzetto,Michelle Melino,Andrew J. Mitchell,Manuela Flórido,Lynette Beattie,Shaun B. Walters,Szun S. Tay,Bo Lu,Bo Lu,Lauren E. Holz,Ben Roediger,Yik Chun Wong,Alessandra Warren,William Ritchie,Claire McGuffog,Wolfgang Weninger,David G. Le Couteur,Florent Ginhoux,Warwick J. Britton,William R. Heath,Bernadette M. Saunders,Bernadette M. Saunders,Geoffrey W. McCaughan,Fabio Luciani,Kelli P. A. MacDonald,Lai Guan Ng,David G. Bowen,Patrick Bertolino +29 more
TL;DR: It is reported here that the hepatic capsule harbors a contiguous cellular network of liver‐resident macrophages phenotypically distinct from KCs, which plays a role in immunosurveillance by sensing peritoneal pathogens and recruiting neutrophils to control intrahepatic bacterial dissemination.