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Barbara H. Jung
Researcher at University of California, San Diego
Publications - 42
Citations - 1621
Barbara H. Jung is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Colorectal cancer & Signal transduction. The author has an hindex of 22, co-authored 39 publications receiving 1507 citations. Previous affiliations of Barbara H. Jung include University of California & Northwestern University.
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Journal ArticleDOI
A Gαi–GIV Molecular Complex Binds Epidermal Growth Factor Receptor and Determines Whether Cells Migrate or Proliferate
Pradipta Ghosh,Anthony Beas,Scott J. Bornheimer,Mikel Garcia-Marcos,Erin P. Forry,Carola Johannson,Jason Ear,Barbara H. Jung,Betty L. Cabrera,John M. Carethers,Marilyn G. Farquhar +10 more
TL;DR: How this cellular decision is made is revealed by showing that a Gαi–GIV molecular complex interacts with EGF receptor and programs growth factor signaling, triggering migration when assembled and favoring mitosis when assembly is prevented.
Journal ArticleDOI
Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers.
Barbara H. Jung,Ryan T. Doctolero,Akihiro Tajima,Alexie K. Nguyen,Temitope O. Keku,Robert S. Sandler,John M. Carethers +6 more
TL;DR: ACVR2 mutations are highly frequent in MSI-H colon cancers and in most cases cause loss of ACVR2 expression, indicating biallelic inactivation of the gene.
Journal ArticleDOI
Bone morphogenetic protein signaling and growth suppression in colon cancer
Stayce E. Beck,Barbara H. Jung,Antonio Fiorino,Jessica Gomez,Eunice Del Rosario,Betty L. Cabrera,Sherry C. Huang,Jimmy Y. C. Chow,John M. Carethers,John M. Carethers +9 more
TL;DR: BMP signaling is intact and growth suppressive in human colon cancer cells, and in addition to SMADs, BMP may utilize SMAD4-independent pathways for growth suppression in colon cancers.
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Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer.
Sung Kwan Shin,Takeshi Nagasaka,Barbara H. Jung,Nagahide Matsubara,Won Ho Kim,John M. Carethers,C. Richard Boland,Ajay Goel +7 more
TL;DR: The majority of CRCs harbor defects in Netrin-1 receptors, emphasizing the importance of this growth regulatory pathway in cancer, and the timing of the molecular alterations in the Netrin -1 receptors is not random.
Journal Article
Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas.
Thomas Vogt,Wilhelm Stolz,John Welsh,Barbara H. Jung,Robert S. Kerbel,Hiroaki Kobayashi,Michael Landthaler,Michael McClelland +7 more
TL;DR: Increased Lerk-5 expression possibly reflects or induces an increased potential of growth, tumorigenicity, and metastatic abilities in human melanomas, which makes the yet to be elucidated eph-related receptor tyrosine kinase/Lerk signaling system a potential new source for molecular markers as well as a target for new therapies.