B
Barbara S. Paugh
Researcher at St. Jude Children's Research Hospital
Publications - 15
Citations - 4101
Barbara S. Paugh is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: PDGFRA & Sphingosine kinase 1. The author has an hindex of 12, co-authored 15 publications receiving 3495 citations. Previous affiliations of Barbara S. Paugh include Virginia Commonwealth University & University of Tennessee Health Science Center.
Papers
More filters
Journal ArticleDOI
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
Gang Wu,Alberto Broniscer,Troy A. McEachron,Charles Lu,Barbara S. Paugh,Jared Becksfort,Chunxu Qu,Li Ding,Robert Huether,Matthew Parker,Junyuan Zhang,Amar Gajjar,Michael A. Dyer,Charles G. Mullighan,Richard J. Gilbertson,Elaine R. Mardis,Richard K. Wilson,James R. Downing,David W. Ellison,Jinghui Zhang,Suzanne J. Baker +20 more
TL;DR: To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPG and 36 non-brainstem pediatric glioblastomas (non-BS-PGs) were performed.
Journal ArticleDOI
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
Gang Wu,Alexander K. Diaz,Alexander K. Diaz,Barbara S. Paugh,Sherri Rankin,Bensheng Ju,Yongjin Li,Xiaoyan Zhu,Chunxu Qu,Xiang Chen,Junyuan Zhang,John Easton,Michael N. Edmonson,Xiaotu Ma,Charles Lu,Panduka Nagahawatte,Erin Hedlund,Michael Rusch,Stanley Pounds,Tong Lin,Arzu Onar-Thomas,Robert Huether,Richard W. Kriwacki,Matthew Parker,Pankaj Gupta,Jared Becksfort,Lei Wei,Heather L. Mulder,Kristy Boggs,Bhavin Vadodaria,Donald Yergeau,Jake C. Russell,Kerri Ochoa,Robert S. Fulton,Lucinda Fulton,Chris Jones,Frederick A. Boop,Alberto Broniscer,Cynthia Wetmore,Amar Gajjar,Li Ding,Elaine R. Mardis,Richard K. Wilson,Michael R. Taylor,James R. Downing,David W. Ellison,Jinghui Zhang,Suzanne J. Baker,Suzanne J. Baker +48 more
TL;DR: In this article, the authors analyzed 127 pediatric HGGs, including diffuse intrinsic pontine gliomas (DIPGs) and non-brainstem HGG (NBS-HGGs), by whole-genome, whole-exome and/or transcriptome sequencing.
Journal ArticleDOI
Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key Differences With the Adult Disease
Barbara S. Paugh,Chunxu Qu,Chris Jones,Zhaoli Liu,Martyna Adamowicz-Brice,Junyuan Zhang,Dorine A. Bax,Beth Coyle,Jennifer Barrow,Darren Hargrave,James Lowe,Amar Gajjar,Wei Zhao,Alberto Broniscer,David W. Ellison,Richard Grundy,Suzanne J. Baker +16 more
TL;DR: Integrated molecular profiling showed substantial differences in the molecular features underlying pediatric and adult HGG, indicating that findings in adult tumors cannot be simply extrapolated to younger patients.
Journal ArticleDOI
Genome-Wide Analyses Identify Recurrent Amplifications of Receptor Tyrosine Kinases and Cell-Cycle Regulatory Genes in Diffuse Intrinsic Pontine Glioma
Barbara S. Paugh,Alberto Broniscer,Chunxu Qu,Claudia P. Miller,Junyuan Zhang,Ruth G. Tatevossian,James M. Olson,J. Russell Geyer,Susan N. Chi,Nasjla Saba da Silva,Arzu Onar-Thomas,Justin N. Baker,Amar J. Gajjar,David W. Ellison,Suzanne J. Baker +14 more
TL;DR: Genomic studies suggest that targeted inhibition of receptor tyrosine kinases and RB regulatory proteins may be useful therapies for DIPG.
Journal ArticleDOI
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia
Steven W. Paugh,Barbara S. Paugh,Mohamed Rahmani,Dmitri Kapitonov,Jorge A. Almenara,Tomasz Kordula,Sheldon Milstien,Jeffrey Kroll Adams,Robert Elliot Zipkin,Steven Grant,Sarah Spiegel +10 more
TL;DR: SK1-I potently induced apoptosis in leukemic blasts isolated from patients with acute myelogenous leukemia but was relatively sparing of normal peripheral blood mononuclear leukocytes, and markedly reduced growth of AML xenograft tumors.