R
Ruth G. Tatevossian
Researcher at St. Jude Children's Research Hospital
Publications - 49
Citations - 5234
Ruth G. Tatevossian is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Pilocytic astrocytoma & Astrocytoma. The author has an hindex of 25, co-authored 45 publications receiving 3973 citations. Previous affiliations of Ruth G. Tatevossian include UCL Institute of Child Health & Royal London Hospital.
Papers
More filters
Journal ArticleDOI
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups
Kristian W. Pajtler,Kristian W. Pajtler,Hendrik Witt,Martin Sill,David T.W. Jones,Volker Hovestadt,Fabian Kratochwil,Khalida Wani,Ruth G. Tatevossian,Chandanamali Punchihewa,Pascal Johann,Jüri Reimand,Hans-Jörg Warnatz,Marina Ryzhova,Steve Mack,Vijay Ramaswamy,David Capper,David Capper,Leonille Schweizer,Leonille Schweizer,Laura Sieber,Andrea Wittmann,Zhiqin Huang,Peter van Sluis,Richard Volckmann,Jan Koster,Rogier Versteeg,Daniel W. Fults,Helen Toledano,Smadar Avigad,Lindsey M. Hoffman,Andrew M. Donson,Nicholas K. Foreman,Ekkehard Hewer,Karel Zitterbart,Mark R. Gilbert,Terri S. Armstrong,Terri S. Armstrong,Nalin Gupta,Jeffrey C. Allen,Matthias A. Karajannis,David Zagzag,Martin Hasselblatt,Andreas E. Kulozik,Olaf Witt,V. Peter Collins,Katja von Hoff,Stefan Rutkowski,Torsten Pietsch,Gary D. Bader,Marie-Laure Yaspo,Andreas von Deimling,Andreas von Deimling,Peter Lichter,Michael D. Taylor,Richard J. Gilbertson,David W. Ellison,Kenneth Aldape,Andrey Korshunov,Andrey Korshunov,Marcel Kool,Stefan M. Pfister +61 more
TL;DR: The molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.
Journal ArticleDOI
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
Jinghui Zhang,Gang Wu,Claudia P. Miller,Ruth G. Tatevossian,James Dalton,Bo Tang,Wilda Orisme,Chandanamali Punchihewa,Matthew Parker,Ibrahim Qaddoumi,F.A. Boop,Charles Lu,Cyriac Kandoth,Li Ding,Ryan P. Lee,Robert Huether,Xiang Chen,Erin Hedlund,Panduka Nagahawatte,Michael Rusch,Kristy Boggs,Jinjun Cheng,Jared Becksfort,Jing Ma,Guangchun Song,Yongjin Li,Lei Wei,Jianmin Wang,Sheila A. Shurtleff,John Easton,David Zhao,Robert S. Fulton,Lucinda Fulton,David J. Dooling,Bhavin Vadodaria,Heather L. Mulder,Chunlao Tang,Kerri Ochoa,Charles G. Mullighan,Amar Gajjar,Richard W. Kriwacki,Denise Sheer,Richard J. Gilbertson,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Suzanne J. Baker,David W. Ellison +47 more
TL;DR: Focusing on the therapeutically challenging diffuse LGGs, this study of 151 tumors has discovered genetic alterations and potential therapeutic targets across the entire range of pediatric L GGs and LGGNTs.
Journal ArticleDOI
C11orf95 – RELA fusions drive oncogenic NF-κB signalling in ependymoma
Matthew Parker,Kumarasamypet M. Mohankumar,Chandanamali Punchihewa,Ricardo Weinlich,James Dalton,Yongjin Li,Ryan P. Lee,Ruth G. Tatevossian,Timothy N. Phoenix,Radhika Thiruvenkatam,Elsie White,Bo Tang,Wilda Orisme,Kirti Gupta,Michael Rusch,Xiang Chen,Yuxin Li,Panduka Nagahawhatte,Erin Hedlund,David Finkelstein,Gang Wu,Sheila A. Shurtleff,John Easton,Kristy Boggs,Donald Yergeau,Bhavin Vadodaria,Heather L. Mulder,Jared Becksford,Pankaj Gupta,Robert Huether,Jing Ma,Guangchun Song,Amar Gajjar,Thomas E. Merchant,Frederick A. Boop,Amy A Smith,Li Ding,Charles Lu,Kerri Ochoa,David Zhao,Robert S. Fulton,Lucinda Fulton,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Douglas R. Green,Jinghui Zhang,David W. Ellison,Richard J. Gilbertson +48 more
TL;DR: The data identify a highly recurrent genetic alteration of RELA in human cancer, and the C11orf95–RELA fusion protein as a potential therapeutic target in supratentorial ependymoma.
Journal ArticleDOI
Genome-Wide Analyses Identify Recurrent Amplifications of Receptor Tyrosine Kinases and Cell-Cycle Regulatory Genes in Diffuse Intrinsic Pontine Glioma
Barbara S. Paugh,Alberto Broniscer,Chunxu Qu,Claudia P. Miller,Junyuan Zhang,Ruth G. Tatevossian,James M. Olson,J. Russell Geyer,Susan N. Chi,Nasjla Saba da Silva,Arzu Onar-Thomas,Justin N. Baker,Amar J. Gajjar,David W. Ellison,Suzanne J. Baker +14 more
TL;DR: Genomic studies suggest that targeted inhibition of receptor tyrosine kinases and RB regulatory proteins may be useful therapies for DIPG.
Journal ArticleDOI
Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology
Ibrahim Qaddoumi,Wilda Orisme,Ji Wen,Teresa Santiago,Kirti Gupta,James Dalton,Bo Tang,Kelly Haupfear,Chandanamali Punchihewa,John Easton,Heather L. Mulder,Kristy Boggs,Ying Shao,Michael Rusch,Jared Becksfort,Pankaj Gupta,Shuoguo Wang,Ryan P. Lee,Daniel J. Brat,V. Peter Collins,Sonika Dahiya,David George,William Konomos,Kathreena M Kurian,Kathryn McFadden,Luciano Neder Serafini,Hilary Highfield Nickols,Arie Perry,Sheila A. Shurtleff,Amar Gajjar,F.A. Boop,Paul Klimo,Elaine R. Mardis,Richard K. Wilson,Suzanne J. Baker,Jinghui Zhang,Gang Wu,James R. Downing,Ruth G. Tatevossian,David W. Ellison +39 more
TL;DR: Altered genes in BRAF, FGFR1, or MYB account for most pathogenic alterations in LGNTs, including pilocytic astrocytomas, and alignment of these genetic alterations and cytologic features acrossLGNTs has diagnostic implications.