B
Barbara Savarese
Researcher at PATH
Publications - 22
Citations - 3975
Barbara Savarese is an academic researcher from PATH. The author has contributed to research in topics: RTS,S & Vaccination. The author has an hindex of 20, co-authored 22 publications receiving 3737 citations. Previous affiliations of Barbara Savarese include University of Colorado Denver & University of Virginia.
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Journal ArticleDOI
First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children.
Selidji T Agnandji,Bertrand Lell,Bertrand Lell,Solange Soulanoudjingar,Solange Soulanoudjingar,José Francisco Fernandes,José Francisco Fernandes,Béatrice Peggy Abossolo,Béatrice Peggy Abossolo,Cornelia Conzelmann,Cornelia Conzelmann,Barbara Gaelle Nfono Ondo Methogo,Barbara Gaelle Nfono Ondo Methogo,Yannick Doucka,Yannick Doucka,Arnaud Flamen,Arnaud Flamen,Benjamin Mordmüller,Benjamin Mordmüller,Saadou Issifou,Saadou Issifou,Peter G. Kremsner,Peter G. Kremsner,Jahit Sacarlal,Pedro Aide,Miguel A. Lanaspa,John J. Aponte,Arlindo Nhamuave,Diana Quelhas,Quique Bassat,Sofia Mandjate,Eusebio Macete,Pedro L. Alonso,Salim Abdulla,Nahya Salim,Omar Juma,Mwanajaa Shomari,Kafuruki Shubis,Francisca Machera,Ali Hamad,Rose Minja,Ali Mtoro,Alma Sykes,Saumu Ahmed,Alwisa Urassa,Ali Ali,Grace Mwangoka,Marcel Tanner,Halidou Tinto,Umberto D'Alessandro,Hermann Sorgho,Innocent Valea,Marc Christian Tahita,William Kabore,Sayouba Ouedraogo,Yara Sandrine,Robert T. Guiguemdé,Jean-Bosco Ouédraogo,Mary J. Hamel,Simon Kariuki,Chris Odero,Martina Oneko,Kephas Otieno,Norbert Awino,Jackton Omoto,John Williamson,Vincent Muturi-Kioi,Kayla F. Laserson,Laurence Slutsker,Walter Otieno,Lucas Otieno,Otsyula Nekoye,Stacey M. O. Gondi,Allan Otieno,Bernhards Ogutu,Ruth Wasuna,Victorine Owira,David B. Jones,Agnes Akoth Onyango,Patricia Njuguna,Roma Chilengi,Pauline Akoo,Christine Kerubo,Jesse Gitaka,Charity Maingi,Trudie Lang,Ally Olotu,Benjamin Tsofa,Philip Bejon,Norbert Peshu,Kevin Marsh,Seth Owusu-Agyei,Kwaku Poku Asante,Kingsley Osei-Kwakye,Owusu Boahen,Samuel Ayamba,Kingsley Kayan,Ruth Owusu-Ofori,David Dosoo,Isaac Asante,George Adjei,Daniel Chandramohan,Brian Greenwood,John Lusingu,Samwel Gesase,Anangisye Malabeja,Omari Abdul,Hassan Kilavo,Coline Mahende,Edwin Liheluka,Martha M. Lemnge,Thor G. Theander,Chris Drakeley,Daniel Ansong,Tsiri Agbenyega,Samuel Adjei,Harry Owusu Boateng,Theresa Rettig,John Bawa,Justice Sylverken,David Sambian,Alex Agyekum,Larko Owusu,Francis Martinson,Irving F. Hoffman,Tisungane Mvalo,Portia Kamthunzi,Ruthendo Nkomo,Albans Msika,Allan Jumbe,Nelecy Chome,Dalitso Nyakuipa,Joseph Chintedza,W. Ripley Ballou,Myriam Bruls,Joe Cohen,Yolanda Guerra,Erik Jongert,Didier Lapierre,Amanda J. Leach,Marc Lievens,Opokua Ofori-Anyinam,Johan Vekemans,Terrell Carter,Didier Leboulleux,Christian Loucq,Afiya Radford,Barbara Savarese,David Schellenberg,Marla Sillman,Preeti Vansadia +150 more
TL;DR: The RTS,S/AS01 vaccine provided protection against both clinical and severe malaria in African children, and serious adverse events occurred with a similar frequency in the two study groups.
Journal ArticleDOI
A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants.
Selidji T Agnandji,Selidji T Agnandji,Bertrand Lell,Bertrand Lell,José Francisco Fernandes,José Francisco Fernandes,Béatrice Peggy Abossolo,Béatrice Peggy Abossolo,Barbara Gaelle Nfono Ondo Methogo,Barbara Gaelle Nfono Ondo Methogo,Anita Lumeka Kabwende,Anita Lumeka Kabwende,Ayola A. Adegnika,Ayola A. Adegnika,Benjamin Mordmüller,Benjamin Mordmüller,Saadou Issifou,Saadou Issifou,Peter G. Kremsner,Peter G. Kremsner,Jahit Sacarlal,Pedro Aide,Miguel Lanaspa,John J. Aponte,Sonia Machevo,Sozinho Acácio,Helder Bulo,Betuel Sigaúque,Eusebio Macete,Pedro L. Alonso,Salim Abdulla,Salim Abdulla,Nahya Salim,Nahya Salim,Rose Minja,Rose Minja,Maxmillian Mpina,Maxmillian Mpina,Saumu Ahmed,Saumu Ahmed,Ali Ali,Ali Ali,Ali Mtoro,Ali Mtoro,Ali Hamad,Ali Hamad,Paul Mutani,Paul Mutani,Marcel Tanner,Marcel Tanner,Halidou Tinto,Umberto D'Alessandro,Hermann Sorgho,Innocent Valea,Biebo Bihoun,Issa Guiraud,Berenger Kaboré,Olivier Sombié,Robert T. Guiguemdé,Jean-Bosco Ouédraogo,Mary J. Hamel,Simon Kariuki,Martina Oneko,Chris Odero,Kephas Otieno,Norbert Awino,Meredith McMorrow,Vincent Muturi-Kioi,Kayla F. Laserson,Laurence Slutsker,Walter Otieno,Lucas Otieno,Nekoye Otsyula,Stacey M. O. Gondi,Allan Otieno,Victorine Owira,Esther Oguk,George Odongo,Jon Ben Woods,Bernhards Ogutu,Patricia Njuguna,Roma Chilengi,Pauline Akoo,Christine Kerubo,Charity Maingi,Trudie Lang,Ally Olotu,Philip Bejon,Kevin Marsh,Gabriel Mwambingu,Seth Owusu-Agyei,Kwaku Poku Asante,Kingsley Osei-Kwakye,Owusu Boahen,David Dosoo,Isaac Asante,George Adjei,Evans Kwara,Daniel Chandramohan,Brian Greenwood,John Lusingu,John Lusingu,John Lusingu,Samwel Gesase,Samwel Gesase,Samwel Gesase,Anangisye Malabeja,Anangisye Malabeja,Anangisye Malabeja,Omari Abdul,Omari Abdul,Omari Abdul,Coline Mahende,Coline Mahende,Coline Mahende,Edwin Liheluka,Edwin Liheluka,Edwin Liheluka,Lincoln Malle,Lincoln Malle,Lincoln Malle,M.M. Lemnge,M.M. Lemnge,M.M. Lemnge,Thor G. Theander,Thor G. Theander,Thor G. Theander,Chris Drakeley,Chris Drakeley,Chris Drakeley,Daniel Ansong,Tsiri Agbenyega,Samuel Adjei,Harry Owusu Boateng,Theresa Rettig,John Bawa,Justice Sylverken,David Sambian,Anima Sarfo,Alex Agyekum,Francis Martinson,Irving F. Hoffman,Tisungane Mvalo,Portia Kamthunzi,Rutendo Nkomo,Tapiwa Tembo,Gerald Tegha,Mercy Tsidya,Jane Kilembe,Chimwemwe Chawinga,W. Ripley Ballou,Joe Cohen,Yolanda Guerra,Erik Jongert,Didier Lapierre,Amanda J. Leach,Marc Lievens,Opokua Ofori-Anyinam,Aurélie Olivier,Johan Vekemans,Terrell Carter,David C. Kaslow,Didier Leboulleux,Christian Loucq,Afiya Radford,Barbara Savarese,David Schellenberg,Marla Sillman,Preeti Vansadia +168 more
TL;DR: The RTS,S/AS01 vaccine coadministered with EPI vaccines provided modest protection against both clinical and severe malaria in young infants.
Journal ArticleDOI
Hepatic failure and lactic acidosis due to fialuridine (fiau), an investigational nucleoside analogue for chronic hepatitis b
Robin Mckenzie,Michael W. Fried,Richard Sallie,H. S. Conjeevaram,Adrian M. Di Bisceglie,Yoon Park,Barbara Savarese,David E. Kleiner,Maria Tsokos,Carlos Luciano,Timothy L. Pruett,Jennifer L. Stotka,Stephen E. Straus,Jay H. Hoofnagle +13 more
TL;DR: In patients with chronic hepatitis B, treatment with fialuridine induced a severe toxic reaction characterized by hepatic failure, lactic acidosis, pancreatitis, neuropathy, and myopathy, probably caused by widespread mitochondrial damage and may occur infrequently with other nucleoside analogues.
Journal ArticleDOI
Efficacy of RTS,S/AS01E Vaccine against Malaria in Children 5 to 17 Months of Age
Philip Bejon,John Lusingu,Ally Olotu,Amanda J. Leach,Marc Lievens,Johan Vekemans,Salum Mshamu,Trudie Lang,Jayne Gould,Marie-Claude Dubois,Marie-Ange Demoitié,Jean-Francois Stallaert,Preeti Vansadia,Terrell Carter,Patricia Njuguna,Ken Awuondo,Anangisye Malabeja,Omar Abdul,Samwel Gesase,Neema Mturi,Chris Drakeley,Barbara Savarese,Tonya Villafana,W. Ripley Ballou,Joe Cohen,Eleanor M. Riley,Martha M. Lemnge,Kevin Marsh,Lorenz von Seidlein +28 more
TL;DR: RTS,S/AS01E shows promise as a candidate malaria vaccine as compared with rabies vaccine in children in Kilifi, Kenya, and Korogwe, Tanzania, a target population for vaccine licensure.
Journal ArticleDOI
Safety of the RTS,S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIb trial
John J. Aponte,John J. Aponte,Pedro Aide,Montse Renom,Montse Renom,Inacio Mandomando,Quique Bassat,Quique Bassat,Jahit Sacarlal,Jahit Sacarlal,M. Nelia Manaca,Sarah Lafuente,Arnoldo Barbosa,Arnoldo Barbosa,Amanda J. Leach,Marc Lievens,Johan Vekemans,Betuel Sigaúque,Marie-Claude Dubois,Marie-Ange Demoitié,Marla Sillman,Barbara Savarese,John G McNeil,Eusebio Macete,W. Ripley Ballou,Joe Cohen,Pedro L. Alonso,Pedro L. Alonso +27 more
TL;DR: The RTS,S/AS02D malaria vaccine was safe, well tolerated, and immunogenic in young infants, and set the stage for expanded phase III efficacy studies to confirm vaccine efficacy against clinical malaria disease.