A
Ali Mtoro
Researcher at Ifakara Health Institute
Publications - 19
Citations - 2108
Ali Mtoro is an academic researcher from Ifakara Health Institute. The author has contributed to research in topics: Malaria & Malaria vaccine. The author has an hindex of 9, co-authored 14 publications receiving 1769 citations. Previous affiliations of Ali Mtoro include Muhimbili University of Health and Allied Sciences & Swiss Tropical and Public Health Institute.
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Journal ArticleDOI
First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children.
Selidji T Agnandji,Bertrand Lell,Bertrand Lell,Solange Soulanoudjingar,Solange Soulanoudjingar,José Francisco Fernandes,José Francisco Fernandes,Béatrice Peggy Abossolo,Béatrice Peggy Abossolo,Cornelia Conzelmann,Cornelia Conzelmann,Barbara Gaelle Nfono Ondo Methogo,Barbara Gaelle Nfono Ondo Methogo,Yannick Doucka,Yannick Doucka,Arnaud Flamen,Arnaud Flamen,Benjamin Mordmüller,Benjamin Mordmüller,Saadou Issifou,Saadou Issifou,Peter G. Kremsner,Peter G. Kremsner,Jahit Sacarlal,Pedro Aide,Miguel A. Lanaspa,John J. Aponte,Arlindo Nhamuave,Diana Quelhas,Quique Bassat,Sofia Mandjate,Eusebio Macete,Pedro L. Alonso,Salim Abdulla,Nahya Salim,Omar Juma,Mwanajaa Shomari,Kafuruki Shubis,Francisca Machera,Ali Hamad,Rose Minja,Ali Mtoro,Alma Sykes,Saumu Ahmed,Alwisa Urassa,Ali Ali,Grace Mwangoka,Marcel Tanner,Halidou Tinto,Umberto D'Alessandro,Hermann Sorgho,Innocent Valea,Marc Christian Tahita,William Kabore,Sayouba Ouedraogo,Yara Sandrine,Robert T. Guiguemdé,Jean-Bosco Ouédraogo,Mary J. Hamel,Simon Kariuki,Chris Odero,Martina Oneko,Kephas Otieno,Norbert Awino,Jackton Omoto,John Williamson,Vincent Muturi-Kioi,Kayla F. Laserson,Laurence Slutsker,Walter Otieno,Lucas Otieno,Otsyula Nekoye,Stacey M. O. Gondi,Allan Otieno,Bernhards Ogutu,Ruth Wasuna,Victorine Owira,David B. Jones,Agnes Akoth Onyango,Patricia Njuguna,Roma Chilengi,Pauline Akoo,Christine Kerubo,Jesse Gitaka,Charity Maingi,Trudie Lang,Ally Olotu,Benjamin Tsofa,Philip Bejon,Norbert Peshu,Kevin Marsh,Seth Owusu-Agyei,Kwaku Poku Asante,Kingsley Osei-Kwakye,Owusu Boahen,Samuel Ayamba,Kingsley Kayan,Ruth Owusu-Ofori,David Dosoo,Isaac Asante,George Adjei,Daniel Chandramohan,Brian Greenwood,John Lusingu,Samwel Gesase,Anangisye Malabeja,Omari Abdul,Hassan Kilavo,Coline Mahende,Edwin Liheluka,Martha M. Lemnge,Thor G. Theander,Chris Drakeley,Daniel Ansong,Tsiri Agbenyega,Samuel Adjei,Harry Owusu Boateng,Theresa Rettig,John Bawa,Justice Sylverken,David Sambian,Alex Agyekum,Larko Owusu,Francis Martinson,Irving F. Hoffman,Tisungane Mvalo,Portia Kamthunzi,Ruthendo Nkomo,Albans Msika,Allan Jumbe,Nelecy Chome,Dalitso Nyakuipa,Joseph Chintedza,W. Ripley Ballou,Myriam Bruls,Joe Cohen,Yolanda Guerra,Erik Jongert,Didier Lapierre,Amanda J. Leach,Marc Lievens,Opokua Ofori-Anyinam,Johan Vekemans,Terrell Carter,Didier Leboulleux,Christian Loucq,Afiya Radford,Barbara Savarese,David Schellenberg,Marla Sillman,Preeti Vansadia +150 more
TL;DR: The RTS,S/AS01 vaccine provided protection against both clinical and severe malaria in African children, and serious adverse events occurred with a similar frequency in the two study groups.
Journal ArticleDOI
A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants.
Selidji T Agnandji,Selidji T Agnandji,Bertrand Lell,Bertrand Lell,José Francisco Fernandes,José Francisco Fernandes,Béatrice Peggy Abossolo,Béatrice Peggy Abossolo,Barbara Gaelle Nfono Ondo Methogo,Barbara Gaelle Nfono Ondo Methogo,Anita Lumeka Kabwende,Anita Lumeka Kabwende,Ayola A. Adegnika,Ayola A. Adegnika,Benjamin Mordmüller,Benjamin Mordmüller,Saadou Issifou,Saadou Issifou,Peter G. Kremsner,Peter G. Kremsner,Jahit Sacarlal,Pedro Aide,Miguel Lanaspa,John J. Aponte,Sonia Machevo,Sozinho Acácio,Helder Bulo,Betuel Sigaúque,Eusebio Macete,Pedro L. Alonso,Salim Abdulla,Salim Abdulla,Nahya Salim,Nahya Salim,Rose Minja,Rose Minja,Maxmillian Mpina,Maxmillian Mpina,Saumu Ahmed,Saumu Ahmed,Ali Ali,Ali Ali,Ali Mtoro,Ali Mtoro,Ali Hamad,Ali Hamad,Paul Mutani,Paul Mutani,Marcel Tanner,Marcel Tanner,Halidou Tinto,Umberto D'Alessandro,Hermann Sorgho,Innocent Valea,Biebo Bihoun,Issa Guiraud,Berenger Kaboré,Olivier Sombié,Robert T. Guiguemdé,Jean-Bosco Ouédraogo,Mary J. Hamel,Simon Kariuki,Martina Oneko,Chris Odero,Kephas Otieno,Norbert Awino,Meredith McMorrow,Vincent Muturi-Kioi,Kayla F. Laserson,Laurence Slutsker,Walter Otieno,Lucas Otieno,Nekoye Otsyula,Stacey M. O. Gondi,Allan Otieno,Victorine Owira,Esther Oguk,George Odongo,Jon Ben Woods,Bernhards Ogutu,Patricia Njuguna,Roma Chilengi,Pauline Akoo,Christine Kerubo,Charity Maingi,Trudie Lang,Ally Olotu,Philip Bejon,Kevin Marsh,Gabriel Mwambingu,Seth Owusu-Agyei,Kwaku Poku Asante,Kingsley Osei-Kwakye,Owusu Boahen,David Dosoo,Isaac Asante,George Adjei,Evans Kwara,Daniel Chandramohan,Brian Greenwood,John Lusingu,John Lusingu,John Lusingu,Samwel Gesase,Samwel Gesase,Samwel Gesase,Anangisye Malabeja,Anangisye Malabeja,Anangisye Malabeja,Omari Abdul,Omari Abdul,Omari Abdul,Coline Mahende,Coline Mahende,Coline Mahende,Edwin Liheluka,Edwin Liheluka,Edwin Liheluka,Lincoln Malle,Lincoln Malle,Lincoln Malle,M.M. Lemnge,M.M. Lemnge,M.M. Lemnge,Thor G. Theander,Thor G. Theander,Thor G. Theander,Chris Drakeley,Chris Drakeley,Chris Drakeley,Daniel Ansong,Tsiri Agbenyega,Samuel Adjei,Harry Owusu Boateng,Theresa Rettig,John Bawa,Justice Sylverken,David Sambian,Anima Sarfo,Alex Agyekum,Francis Martinson,Irving F. Hoffman,Tisungane Mvalo,Portia Kamthunzi,Rutendo Nkomo,Tapiwa Tembo,Gerald Tegha,Mercy Tsidya,Jane Kilembe,Chimwemwe Chawinga,W. Ripley Ballou,Joe Cohen,Yolanda Guerra,Erik Jongert,Didier Lapierre,Amanda J. Leach,Marc Lievens,Opokua Ofori-Anyinam,Aurélie Olivier,Johan Vekemans,Terrell Carter,David C. Kaslow,Didier Leboulleux,Christian Loucq,Afiya Radford,Barbara Savarese,David Schellenberg,Marla Sillman,Preeti Vansadia +168 more
TL;DR: The RTS,S/AS01 vaccine coadministered with EPI vaccines provided modest protection against both clinical and severe malaria in young infants.
Journal ArticleDOI
Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial
Michael T. White,Robert Verity,Jamie T. Griffin,Kwaku Poku Asante,Seth Owusu-Agyei,Brian Greenwood,Chris Drakeley,Samwel Gesase,John Lusingu,John Lusingu,Daniel Ansong,Samuel Adjei,Tsiri Agbenyega,Bernhards Ogutu,Lucas Otieno,Walter Otieno,Selidji T Agnandji,Bertrand Lell,Peter G. Kremsner,Irving F. Hoffman,Francis Martinson,Portia Kamthunzu,Halidou Tinto,Innocent Valea,Hermann Sorgho,Martina Oneko,Kephas Otieno,Mary J. Hamel,Nahya Salim,Ali Mtoro,Salim Abdulla,Pedro Aide,Jahit Sacarlal,John J. Aponte,Patricia Njuguna,Kevin Marsh,Kevin Marsh,Philip Bejon,Philip Bejon,Eleanor M. Riley,Azra C. Ghani +40 more
TL;DR: Anti-circumsporozoite antibody titres are a surrogate of protection for the magnitude and duration of R TS,S/AS01 efficacy, with or without a booster dose, providing a valuable surrogate of effectiveness for new RTS,S formulations in the age groups considered.
Journal ArticleDOI
Safety, Immunogenicity, and Protective Efficacy against Controlled Human Malaria Infection of Plasmodium falciparum Sporozoite Vaccine in Tanzanian Adults.
Said Jongo,Seif Shekalaghe,L. W. Preston Church,Adam Ruben,Tobias Schindler,Tobias Schindler,Isabelle Zenklusen,Isabelle Zenklusen,Tobias Rutishauser,Tobias Rutishauser,Julian Rothen,Julian Rothen,Anneth Tumbo,Catherine Mkindi,Maximillian Mpina,Ali Mtoro,Andrew S. Ishizuka,Kamaka R Kassim,Florence A. Milando,Munira Qassim,Omar Juma,Solomon Mwakasungula,Beatus Simon,Eric R. James,Yonas Abebe,Natasha Kc,Sumana Chakravarty,Elizabeth Saverino,Bakari M Bakari,Peter F. Billingsley,Robert A. Seder,Claudia Daubenberger,Claudia Daubenberger,B. Kim Lee Sim,Thomas L. Richie,Marcel Tanner,Marcel Tanner,Salim Abdulla,Stephen L. Hoffman +38 more
TL;DR: The same dosage regimen was used in the United States and Mali to evaluate the tolerability, safety, immunogenicity, and VE of PfSPZ Vaccine in young adult male Tanzanians and found it was less immunogenic and protective in Tanzanian volunteers than in Americans.
Journal ArticleDOI
Safety and Differential Antibody and T-Cell Responses to the Plasmodium falciparum Sporozoite Malaria Vaccine, PfSPZ Vaccine, by Age in Tanzanian Adults, Adolescents, Children, and Infants.
Said Jongo,L. W. Preston Church,Ali Mtoro,Sumana Chakravarty,Adam Ruben,Phillip A. Swanson,Kamaka R Kassim,Maximillian Mpina,Maximillian Mpina,Anneth-Mwasi Tumbo,Anneth-Mwasi Tumbo,Florence A. Milando,Munira Qassim,Omar Juma,Bakari M Bakari,Beatus Simon,Eric R. James,Yonas Abebe,Natasha Kc,Elizabeth Saverino,Linda Gondwe,Linda Gondwe,Fabian Studer,Fabian Studer,Martina Fink,Martina Fink,Glenda Cosi,Glenda Cosi,Jill El-Khorazaty,David Styers,Robert A. Seder,Tobias Schindler,Tobias Schindler,Peter F. Billingsley,Claudia Daubenberger,Claudia Daubenberger,B. Kim Lee Sim,Marcel Tanner,Marcel Tanner,Thomas L. Richie,Salim Abdulla,Stephen L. Hoffman +41 more
TL;DR: The T-cell data suggest PfSPZ Vaccine may be more protective in children than in adults, whereas infants may not be immunologically mature enough to respond to the PfSPz Vaccine immunization regimen assessed.