Bartek Wilczyński

TL;DR: This new approach to obtain cell type–specific information on chromatin state and RNA polymerase II (Pol II) occupancy within the multicellular Drosophila melanogaster embryo identifies dynamic enhancer usage, an essential step in deciphering developmental networks.

TL;DR: The quality of inferred networks dramatically improves when using data from perturbation experiments and it is concluded that the exact algorithm should be used when it is possible, i.e. when considered set of genes is small enough.

TL;DR: The results of global occupancy studies demonstrate that, while H1.3 has the same overall binding properties as the main H1 variants, including predominant heterochromatin localization, it differs from them in its preferences for chromatin regions with epigenetic signatures of active and repressed transcription.

TL;DR: The current challenges in moving from modeling medium scale well-characterized networks to more poorly characterized global networks are explored and coarse- and find-grain approaches to model gene regulatory networks in cis are suggested.

TL;DR: Interestingly, in addition to genes showing canonical pattern of BRM enrichment near transcription start site, many other genes showed a transcription termination site-centred BRM occupancy profile, suggesting that binding to gene terminators and controlling transcription of non-coding RNAs is another way through which SWI/SNF complex regulates expression of its targets.