E
E. Hilary Gustafson
Researcher at European Bioinformatics Institute
Publications - 11
Citations - 1773
E. Hilary Gustafson is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Enhancer & Transcription factor. The author has an hindex of 9, co-authored 11 publications receiving 1478 citations. Previous affiliations of E. Hilary Gustafson include Austrian Academy of Sciences & Rockefeller University.
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Journal ArticleDOI
Guided self-organization and cortical plate formation in human brain organoids
Madeline A. Lancaster,Madeline A. Lancaster,Nina S. Corsini,Simone Wolfinger,E. Hilary Gustafson,Alex W Phillips,Thomas R Burkard,Tomoki Otani,Frederick J. Livesey,Juergen A. Knoblich +9 more
TL;DR: Microfilament-engineered cerebral organoids (enCORs) model the distinctive radial organization of the cerebral cortex and allow for the study of neuronal migration and demonstrate that combining 3D cell culture with bioengineering can increase reproducibility and improve tissue architecture.
Journal ArticleDOI
Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development.
Stefan Bonn,Robert P. Zinzen,Charles Girardot,E. Hilary Gustafson,Alexis Perez-Gonzalez,Nicolas Delhomme,Yad Ghavi-Helm,Bartek Wilczyński,Andrew Riddell,Eileen E. M. Furlong +9 more
TL;DR: This new approach to obtain cell type–specific information on chromatin state and RNA polymerase II (Pol II) occupancy within the multicellular Drosophila melanogaster embryo identifies dynamic enhancer usage, an essential step in deciphering developmental networks.
Journal ArticleDOI
A Transcription Factor Collective Defines Cardiac Cell Fate and Reflects Lineage History
Guillaume Junion,Mikhail Spivakov,Charles Girardot,Martina Braun,E. Hilary Gustafson,Ewan Birney,Eileen E. M. Furlong +6 more
TL;DR: It is demonstrated that the five genetic components essential for cardiac specification in Drosophila, including the effectors of Wg and Dpp signaling, act as a collective unit to cooperatively regulate heart enhancer activity, both in vivo and in–vitro.
Journal ArticleDOI
Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks
Enrico Cannavò,Pierre Khoueiry,David A. Garfield,Paul Geeleher,Thomas Zichner,E. Hilary Gustafson,Lucia Ciglar,Jan O. Korbel,Eileen E. M. Furlong +8 more
TL;DR: Embryogenesis is remarkably robust to segregating mutations and environmental variation; under a range of conditions, embryos of a given species develop into stereotypically patterned organisms and patterns of segregating variation suggest that they play a more complex role in development than generally considered.
Journal ArticleDOI
Model-based Method for Transcription Factor Target Identification with Limited Data
Antti Honkela,Charles Girardot,E. Hilary Gustafson,Ya Hsin Liu,Eileen E. M. Furlong,Neil D. Lawrence,Magnus Rattray +6 more
TL;DR: The approach is found to be comparable or superior to ranking based on mutant differential expression scores, and it is shown how integrating complementary wild-type spatial expression data can further improve target ranking performance.