Beáta Tóth

TL;DR: A novel microglia type associated with neurodegenerative diseases (DAM) is described and it is revealed that the DAM program is activated in a two-step process that involves downregulation of microglian checkpoints, followed by activation of a Trem2-dependent program.

TL;DR: This work measures the entire transcriptome of thousands of mouse liver cells and infer their lobule coordinates on the basis of a panel of zonated landmark genes, characterized with single-molecule fluorescence in situ hybridization and finds that around 50% of liver genes are significantly zonation and uncover abundant non-monotonic profiles that peak at the mid-lobule layers.

TL;DR: An activity of caspase-8 in dendritic cells that controls the initiation of inflammation in another way is described, providing new insight into potentially pathological inflammatory processes to which RIPK1- and RIPK3-mediated signaling contributes.

TL;DR: Subepithelial telocytes are identified as a source of Wnt signals that enable proliferation and differentiation of intestinal stem cells, an essential function for maintenance of the intestinal epithelium.

TL;DR: Paired-cell sequencing was used, in which mRNA from pairs of attached mouse cells were sequenced and gene expression from one cell type was used to infer the pairs' tissue coordinates, and revealed the expression of both Wnt ligands and the Dkk3 Wnt antagonist in distinct pericentral LEC sub-populations.