K
Kirk J. Wangensteen
Researcher at University of Pennsylvania
Publications - 58
Citations - 2825
Kirk J. Wangensteen is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 19, co-authored 48 publications receiving 2101 citations. Previous affiliations of Kirk J. Wangensteen include University of Minnesota & University of Vermont.
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Journal ArticleDOI
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Zhixun Dou,Kanad Ghosh,Maria Grazia Vizioli,Jiajun Zhu,Payel Sen,Kirk J. Wangensteen,Johayra Simithy,Yemin Lan,Yanping Lin,Zhuo Zhou,Brian C. Capell,Caiyue Xu,Mingang Xu,Julia E. Kieckhaefer,Tianying Jiang,Michal Shoshkes-Carmel,K M Ahasan Al Tanim,Glen N. Barber,John T. Seykora,Sarah E. Millar,Klaus H. Kaestner,Benjamin A. Garcia,Peter D. Adams,Peter D. Adams,Shelley L. Berger +24 more
TL;DR: It is shown that cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING (cyclic GMP–AMP synthase linked to stimulator of interferon genes) pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer.
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Subepithelial telocytes are an important source of Wnts that supports intestinal crypts
Michal Shoshkes-Carmel,Yue J. Wang,Kirk J. Wangensteen,Beáta Tóth,Ayano Kondo,Efi E. Massasa,Shalev Itzkovitz,Klaus H. Kaestner +7 more
TL;DR: Subepithelial telocytes are identified as a source of Wnt signals that enable proliferation and differentiation of intestinal stem cells, an essential function for maintenance of the intestinal epithelium.
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Harnessing a high cargo-capacity transposon for genetic applications in vertebrates.
Darius Balciunas,Kirk J. Wangensteen,Andrew Wilber,Jason B. Bell,Aron M. Geurts,Sridhar Sivasubbu,Xin-Xin Wang,Perry B. Hackett,David A. Largaespada,R. Scott McIvor,Stephen C. Ekker +10 more
TL;DR: It is shown that the Tol2 transposon can efficiently integrate DNA sequences larger than 10 kb into human cells and provides a novel nonviral vector for the delivery of large genetic payloads for gene therapy and other transgenic applications.
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Reprogramming Fibroblasts into Bipotential Hepatic Stem Cells by Defined Factors
Bing Yu,Zhiying He,Pu You,Qing-Wang Han,Dao Xiang,Fei Chen,Min-Jun Wang,Changcheng Liu,Xi-Wen Lin,Uyunbilig Borjigin,Xiao-Yuan Zi,Jian-Xiu Li,Haiying Zhu,Wenlin Li,Chun-Sheng Han,Kirk J. Wangensteen,Yufang Shi,Yufang Shi,Lijian Hui,Xin Wang,Xin Wang,Xin Wang,Yi-Ping Hu +22 more
TL;DR: It is shown that Hnf1β and Foxa3, liver organogenesis transcription factors, are sufficient to reprogram MEFs into induced hepatic stem cells (iHepSCs), a strategy to enable efficient derivation of both hepatocytes and cholangiocytes for use in disease modeling and tissue engineering.
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Collagen tube conduits in peripheral nerve repair: a retrospective analysis.
TL;DR: The results indicate that NeuraGen® collagen conduits can be used safely throughout the body and sensory recovery was in the 35–45% range in the experience.