Journal ArticleDOI
Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
Mauro Di Ianni,Mauro Di Ianni,Franca Falzetti,Alessandra Carotti,Adelmo Terenzi,Flora Castellino,Elisabetta Bonifacio,Beatrice Del Papa,Tiziana Zei,Roberta Iacucci Ostini,Debora Cecchini,Teresa Aloisi,Katia Perruccio,Loredana Ruggeri,Chiara Balucani,Antonio Pierini,Paolo Sportoletti,Cynthia Aristei,Brunangelo Falini,Yair Reisner,Andrea Velardi,Franco Aversa,Massimo F. Martelli +22 more
TLDR
It is shown for the first time in humans that adoptive transfer of Tregs prevented GVHD in the absence of any posttransplantation immunosuppression, promoted lymphoid reconstitution, improved immunity to opportunistic pathogens, and did not weaken the graft-versus-leukemia effect.About:
This article is published in Blood.The article was published on 2011-04-07. It has received 982 citations till now. The article focuses on the topics: Transplantation & Immunosuppression.read more
Citations
More filters
Journal ArticleDOI
Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease
John Koreth,Ken-ichi Matsuoka,Haesook T. Kim,Sean McDonough,Bhavjot Bindra,Edwin P. Alyea,Philippe Armand,Corey Cutler,Vincent T. Ho,Nathaniel S. Treister,Don C. Bienfang,Sashank Prasad,Dmitrios Tzachanis,Robin Joyce,David Avigan,Joseph H. Antin,Jerome Ritz,Robert J. Soiffer +17 more
TL;DR: Daily low-dose interleukin-2 was safely administered in patients with active chronic GVHD that was refractory to glucocorticoid therapy and was associated with preferential, sustained Treg cell expansion in vivo and amelioration of the manifestations of chronic GvHD in a substantial proportion of patients.
Journal ArticleDOI
tTregs, pTregs, and iTregs: Similarities and Differences
TL;DR: Novel systems in which the function of Tregs can be evaluated in vivo in normal mice are developed and one prominent mechanism of action of polyclonal tTregs is to inhibit T‐effector cell trafficking to the target organ, while antigen‐specific iTregs primarily prevent T‐cell priming by acting on antigen‐presenting dendritic cells (DCs).
Journal ArticleDOI
Regulatory immune cells in transplantation
TL;DR: The leukocyte populations that can promote immune tolerance after cell or solid-organ transplantation are discussed, including regulatory T cells, B cells and macrophages, as well as myeloid-derived suppressor cells, dendritic cells and mesenchymal stromal cells.
Journal ArticleDOI
Homeostatic control of regulatory T cell diversity.
Adrian Liston,Daniel H.D. Gray +1 more
TL;DR: It is highlighted how differing local milieu might drive context-specific TReg cell function and restoration of immune homeostasis, and how dysregulation of these processes can precipitate disease.
Journal ArticleDOI
Administration of CD4+CD25highCD127− Regulatory T Cells Preserves β-Cell Function in Type 1 Diabetes in Children
Natalia Marek-Trzonkowska,MaŁgorzata Myśliwiec,Anita Dobyszuk,Marcelina Grabowska,Ilona Techmańska,Jolanta Juścińska,Magdalena A. Wujtewicz,Piotr Witkowski,Wojciech Młynarski,Anna Balcerska,Jolanta Myśliwska,Piotr Trzonkowski +11 more
TL;DR: It is shown for the first time that the infusion of autologous Tregs prolongs remission in recently diagnosed type 1 diabetes in children and is safe and tolerable in children with recent-onset type 2 diabetes.
References
More filters
Journal ArticleDOI
Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants
Loredana Ruggeri,Marusca Capanni,Elena Urbani,Katia Perruccio,Warren D. Shlomchik,Antonella Tosti,Sabrina Posati,Daniela Rogaia,Francesco Frassoni,Franco Aversa,Massimo F. Martelli,Andrea Velardi +11 more
TL;DR: It is shown that donor-versus-recipient natural killer (NK)–cell alloreactivity could eliminate leukemia relapse and graft rejection and protect patients against GVHD in human transplants and in mice, the pretransplant infusion of alloreactive NK cells obviated the need for high-intensity conditioning and reduced GV HD.
Journal ArticleDOI
CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation.
Matthias Edinger,Matthias Edinger,Petra Hoffmann,Petra Hoffmann,Joerg Ermann,Kathryn Drago,C. Garrison Fathman,Samuel Strober,Robert S. Negrin +8 more
TL;DR: It is demonstrated that in host mice with leukemia and lymphoma, CD4+CD25+ regulatory T cells suppress the early expansion of alloreactive donor T cells, their interleukin-2-receptor (IL-2R) α-chain expression and their capacity to induce GVHD without abrogating their GVT effector function, mediated primarily by the perforin lysis pathway.
Journal ArticleDOI
Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype.
Franco Aversa,Antonio Tabilio,Andrea Velardi,Cunningham I,Adelmo Terenzi,F. Falzetti,Loredana Ruggeri,G. Barbabietola,Cynthia Aristei,Paolo Latini,Yair Reisner,M F Martelli +11 more
TL;DR: The main limitations of transplantation of bone marrow from donors who are matched with the recipient for only one HLA haplotype GVHD and graft failure - can be overcome.
Journal ArticleDOI
Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation
TL;DR: It is demonstrated that the balance of donor-type CD4+CD25+ Treg and conventional CD4-CD25− T cells can determine the outcome of aGVHD, and the addition of the Treg cells at a 1:1 ratio with responder/inducer CD4+.
Journal ArticleDOI
The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality.
TL;DR: This study is the first to demonstrate that activated, cultured CD4(+)CD25(+) cells can offer substantial protection in a relevant in vivo animal model of disease and have important ramifications for clinical bone marrow and solid organ transplantation.