B
Ben J.M. Witteman
Researcher at Wageningen University and Research Centre
Publications - 134
Citations - 7183
Ben J.M. Witteman is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Pancreatitis & Acute pancreatitis. The author has an hindex of 35, co-authored 112 publications receiving 5867 citations.
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Journal ArticleDOI
Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial
Marc G. Besselink,Hjalmar C. van Santvoort,Erik Buskens,Erik Buskens,Marja A. Boermeester,Harry van Goor,Harro M. Timmerman,Vincent B. Nieuwenhuijs,Thomas L. Bollen,Bert van Ramshorst,Ben J.M. Witteman,Camiel Rosman,Rutger J. Ploeg,Menno A. Brink,Alexander F. Schaapherder,Cornelis H. C. Dejong,Peter J. Wahab,Cees J. H. M. van Laarhoven,Erwin van der Harst,Casper H.J. van Eijck,Miguel A. Cuesta,Louis M. A. Akkermans,Hein G. Gooszen +22 more
TL;DR: In patients with predicted severe acute pancreatitis, probiotic prophylaxis with this combination of probiotic strains did not reduce the risk of infectious complications and was associated with an increased risk of mortality.
Journal Article
Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Commentary
Juhani Sand,Isto Nordback,Marc G. Besselink,Hjalmar C. van Santvoort,Erik Buskens,Marja A. Boermeester,Harry van Goor,Harro M. Timmerman,Vincent B. Nieuwenhuijs,Thomas L. Bollen,Bert van Ramshorst,Ben J.M. Witteman,Camiel Rosman,Rutger J. Ploeg,Menno A. Blink,Alexander F. Schaapherder,Cornelis H. C. Dejong,Peter J. Wahab,Ceesj H. M. Van Laarhoven,Erwin van der Harst,Casper H.J. van Eijck,Miguel A. Cuesta,Louis M. A. Akkermans,Hein G. Gooszen +23 more
TL;DR: In this article, the effects of probiotic prophylaxis in patients with predicted severe acute pancreatitis were evaluated in a multicentre randomised, double-blind, placebo-controlled trial.
Journal ArticleDOI
Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis.
Kirsten Boonstra,Rinse K. Weersma,Karel J. van Erpecum,Erik A.J. Rauws,B W Marcel Spanier,Alexander C. Poen,Karin M.J. van Nieuwkerk,Joost P.H. Drenth,Ben J.M. Witteman,H.A.R.E. Tuynman,Anton H. Naber,Paul J. Kingma,Henk R. van Buuren,Bart van Hoek,Frank P. Vleggaar,Nan van Geloven,Ulrich Beuers,Cyriel Y. Ponsioen +17 more
TL;DR: This study exemplifies that, for relatively rare diseases, it is paramount to collect observational data from large, population‐based cohorts, because incidence and prevalence rates of PSC are markedly lower and survival much longer than previously reported.
Journal ArticleDOI
Endoscopic or surgical step-up approach for infected necrotising pancreatitis : A multicentre randomised trial
Sandra van Brunschot,Janneke van Grinsven,Hjalmar C. van Santvoort,Olaf J. Bakker,Marc G. Besselink,Marja A. Boermeester,Thomas L. Bollen,Koop Bosscha,Stefan A.W. Bouwense,Marco J. Bruno,Vincent C. Cappendijk,Esther C. J. Consten,Cornelis H. C. Dejong,Casper H.J. van Eijck,Willemien G. Erkelens,Harry van Goor,Wilhelmina M U van Grevenstein,Jan Willem Haveman,Sijbrand Hofker,Jeroen M. Jansen,Johan S. Laméris,Krijn P. van Lienden,Maarten Meijssen,Chris J. J. Mulder,Vincent B. Nieuwenhuijs,Jan-Werner Poley,Rutger Quispel,Rogier de Ridder,Tessa E H Römkens,Joris J. Scheepers,Nicolien J. Schepers,Matthijs P. Schwartz,Tom C.J. Seerden,B W Marcel Spanier,Jan Willem A Straathof,Marin Strijker,Robin Timmer,Niels G. Venneman,Frank P. Vleggaar,Rogier P. Voermans,Ben J.M. Witteman,Hein G. Gooszen,Marcel G. W. Dijkgraaf,Paul Fockens,Eric R. Manusama,Mohammed Hadithi,Camiel Rosman,Alexander F. Schaapherder,Erik J. Schoon +48 more
TL;DR: In patients with infected necrotising pancreatitis, the endoscopic step-up approach was not superior to the surgical step- up approach in reducing major complications or death, and the rate of pancreatic fistulas and length of hospital stay were lower in the endoscopy group.
Journal ArticleDOI
Improved Prognosis of Patients With Primary Biliary Cirrhosis That Have a Biochemical Response to Ursodeoxycholic Acid
Edith M.M. Kuiper,Bettina E. Hansen,Richard A. de Vries,Jannie W. den Ouden Muller,Theo J.M. van Ditzhuijsen,E. B. Haagsma,M. H. M. G. Houben,Ben J.M. Witteman,Karel J. van Erpecum,Henk R. van Buuren +9 more
TL;DR: Prognosis for UDCA-treated patients with early PBC is comparable to that of the general population and survival of those with advanced PBC with biochemical response to UDCA is significantly better than for nonresponders.