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Benjamin A. Garcia
Researcher at University of Pennsylvania
Publications - 467
Citations - 40286
Benjamin A. Garcia is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 90, co-authored 425 publications receiving 31491 citations. Previous affiliations of Benjamin A. Garcia include Ludwig Maximilian University of Munich & Purdue University.
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Patent
Sequence-specific extraction and analysis of dna-bound proteins
TL;DR: An automated protein preparation technology that may use magnetic microparticles to isolate proteins in their native state from specific genomic loci of interest via the chromatin to which they are bound is described in this article.
Proceedings ArticleDOI
The spectrograph ESOPO: scientific goals, high-level requirements, and introduction to the design
Juan Echevarria,Alejandro Farah,R. Costero,J. Jesús González,Gerardo Avila,M. Arroyo,F. Cobos,E. Colorado,A. Córdova,O. Chapa,Benjamin A. Garcia,F. Garfias,F. Granados,G. Guisa,Esteban Luna,Benjamin Martinez,R. Michel,F. Murillo,Maria H. Pedrayes,F. Pérez,S. Quechol,F. Quirós,Gerardo Sierra,Carlos Tejada +23 more
TL;DR: The Medium Resolution Spectrograph ESOPO is presented, an instrument designed and built for the 2.1m Telescope at the Observatorio Astronómico Nacional at San Pedro Mártir, and an introduction to its conceptual dual-arm design is made.
Proceedings ArticleDOI
Abstract PR07: Human chimeric antigen receptor (CAR) macrophages for cancer immunotherapy
Michael Klichinsky,Marco Ruella,Olga Shestova,Andrew Best,Kristin Blouch,Xueqing Maggie Lu,Saad S. Kenderian,Miriam Y. Kim,Roddy S. O’Connor,Stephen R. Wallace,Miroslaw Kozlowski,Dylan M. Marchione,Maksim Shestov,Benjamin A. Garcia,Carl H. June,Saar Gill +15 more
TL;DR: It is shown that primary human CAR macrophages are capable of targeted tumor phagocytosis, lead to improved overall survival in xenograft models, and demonstrate enhanced T-cell stimulation.
Journal ArticleDOI
Global Microbiota-Dependent Histone Acetylation Patterns Are Irreversible and Independent of Short Chain Fatty Acids
Yedidya Saiman,Ting-Chin David Shen,Peder J. Lund,Victoria M. Gershuni,Cholsoon Jang,Shivali Patel,Sunhee Jung,Emma E. Furth,Elliot S. Friedman,Lillian Chau,Benjamin A. Garcia,Gary D. Wu +11 more
TL;DR: In this paper, the authors demonstrate that global hepatic histone acetylation states measured by mass spectrometry remained largely unchanged despite loss of luminal and portal vein SCFAs after antibiotic-mediated microbiota depletion.
Posted ContentDOI
Cell-Type-Specific Epigenetic Priming of Gene Expression in Nucleus Accumbens by Cocaine
Philipp Mews,Yentl Y. van der Zee,Hope Kronman,Ashik Gurung,Aarthi Ramakrishnan,Caleb J. Browne,Rita Futamura,Molly Estill,Meagan Ryan,Abner A Reyes,Benjamin A. Garcia,Simone Sidoli,Li Shen,Eric J. Nestler +13 more
TL;DR: A novel epigenetic mechanism whereby chronic cocaine exposure causes lasting chromatin and downstream transcriptional modifications in the nucleus accumbens (NAc), a critical brain region controlling motivation is described.