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Benjamin A. Garcia
Researcher at University of Pennsylvania
Publications - 467
Citations - 40286
Benjamin A. Garcia is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 90, co-authored 425 publications receiving 31491 citations. Previous affiliations of Benjamin A. Garcia include Ludwig Maximilian University of Munich & Purdue University.
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Journal ArticleDOI
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer
Pawel K. Mazur,Nicolas Reynoird,Purvesh Khatri,Pascal W. T. C. Jansen,Alex W. Wilkinson,Shichong Liu,Olena Barbash,Glenn S. Van Aller,Michael J. Huddleston,Dashyant Dhanak,Peter J. Tummino,Ryan G. Kruger,Benjamin A. Garcia,Atul J. Butte,Michiel Vermeulen,Julien Sage,Or Gozani +16 more
TL;DR: In this article, the authors used protein array technology to identify the MAP3K2 kinase as a target of SMYD3 and showed that methylation of MAP 3K2 by SMYD 3 increases MAP kinase signalling and promotes the formation of Ras-driven carcinomas.
Journal ArticleDOI
Organismal differences in post-translational modifications in histones H3 and H4.
Benjamin A. Garcia,Sandra B. Hake,Robert L. Diaz,Monika Kauer,Stephanie A. Morris,Judith Recht,Jeffrey Shabanowitz,Nilamadhab Mishra,Brian D. Strahl,C. David Allis,Donald F. Hunt +10 more
TL;DR: It is suggested that some post-translational modifications of histones are more conserved than previously thought, including H3K9me1 and H4K20me2 in yeast and H2K27me1, -me2, and -me3 in Tet.
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Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
Chao Lu,Siddhant U. Jain,Dominik Hoelper,Denise Bechet,Rosalynn C. Molden,Rosalynn C. Molden,Leili Ran,Devan Murphy,Sriram Venneti,Meera Hameed,Bruce R. Pawel,Jay S. Wunder,Jay S. Wunder,Brendan C. Dickson,Brendan C. Dickson,Stefan M. Lundgren,Krupa S. Jani,Nicolas De Jay,Simon Papillon-Cavanagh,Irene L. Andrulis,Sarah L. Sawyer,David Grynspan,Robert E. Turcotte,Javad Nadaf,Somayyeh Fahiminiyah,Tom W. Muir,Jacek Majewski,Craig B. Thompson,Ping Chi,Ping Chi,Benjamin A. Garcia,C. David Allis,Nada Jabado,Peter W. Lewis +33 more
TL;DR: It is reported that the H3 lysine 36–to-methionine (H3K36M) mutation impairs the differentiation of mesenchymal progenitor cells and generates undifferentiated sarcoma in vivo.
Journal ArticleDOI
Comprehensive Catalog of Currently Documented Histone Modifications
Yingming Zhao,Benjamin A. Garcia +1 more
TL;DR: This work catalogs histone PTMs under two classes: first, those whose functions have been fairly well studied and, second, those PTMs that have been more recently identified but whose functions remain unclear.
Journal ArticleDOI
Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation
Kristel M. Dorighi,Tomek Swigut,Telmo Henriques,Natarajan V. Bhanu,Benjamin S. Scruggs,Nataliya Nady,Christopher D. Still,Benjamin A. Garcia,Karen Adelman,Joanna Wysocka +9 more
TL;DR: The results suggest that enhancer H3K4me1 provides only a minor contribution to the long-range coactivator function of Mll3/4, and downregulated genes exhibit reduced polymerase levels in gene bodies, but not at promoters, suggestive of pause-release defects.