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Benjamin A. Garcia
Researcher at University of Pennsylvania
Publications - 467
Citations - 40286
Benjamin A. Garcia is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 90, co-authored 425 publications receiving 31491 citations. Previous affiliations of Benjamin A. Garcia include Ludwig Maximilian University of Munich & Purdue University.
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Journal ArticleDOI
RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2.
Qi Zhang,Nicholas J. McKenzie,Robert Warneford-Thomson,Emma H Gail,Sarena F. Flanigan,Brady M. Owen,Richard Lauman,Vitalina Levina,Benjamin A. Garcia,Ralf B. Schittenhelm,Roberto Bonasio,Chen Davidovich,Chen Davidovich +12 more
TL;DR: In vivo and in vitro protein-RNA interaction maps identify an RNA-binding patch within the allosteric regulatory site ofPRC2 that explains how RNA-mediated inhibition of PRC2 is relieved by allosterics activation.
Journal ArticleDOI
Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis
Carol C.L. Chen,Shriya Deshmukh,Selin Jessa,Selin Jessa,Djihad Hadjadj,Véronique Lisi,Augusto Faria Andrade,Damien Faury,Wajih Jawhar,Rola Dali,Hiromichi Suzuki,Manav Pathania,Manav Pathania,Deli A,Frank Dubois,Eleanor Woodward,Steven Hébert,Steven Hébert,Marie Coutelier,Marie Coutelier,Jason Karamchandani,Steffen Albrecht,Sebastian Brandner,Nicolas De Jay,Nicolas De Jay,Tenzin Gayden,Andrea Bajic,Ashot S. Harutyunyan,Dylan M. Marchione,Leonie G. Mikael,Nikoleta Juretic,Michele Zeinieh,Caterina Russo,Nicola Maestro,Angelia V. Bassenden,Peter Hauser,József Virga,László Bognár,Almos Klekner,Michal Zapotocky,Ales Vicha,Lenka Krskova,Katerina Vanova,Josef Zamecnik,David Sumerauer,Paul G Ekert,David S. Ziegler,David S. Ziegler,Benjamin Ellezam,Mariella G. Filbin,Mathieu Blanchette,Jordan R. Hansford,Dong Anh Khuong-Quang,Albert M. Berghuis,Alexander G. Weil,Benjamin A. Garcia,Livia Garzia,Livia Garzia,Stephen C. Mack,Rameen Beroukhim,Rameen Beroukhim,Keith L. Ligon,Keith L. Ligon,Michael D. Taylor,Pratiti Bandopadhayay,Pratiti Bandopadhayay,CM Kramm,Stefan M. Pfister,Stefan M. Pfister,Andrey Korshunov,Andrey Korshunov,Dominik Sturm,Dominik Sturm,David T.W. Jones,Paolo Salomoni,Claudia L. Kleinman,Claudia L. Kleinman,Nada Jabado,Nada Jabado +78 more
TL;DR: It is shown that 50% of G34R/V tumors bear activating PDGFRA mutations that display strong selection pressure at recurrence, and these results open novel research avenues in deadly tumors.
Journal ArticleDOI
BclAF1 restriction factor is neutralized by proteasomal degradation and microRNA repression during human cytomegalovirus infection.
Song Hee Lee,Robert F. Kalejta,Julie A. Kerry,Oliver John Semmes,Christine M. O’Connor,Zia Khan,Benjamin A. Garcia,Thomas Shenk,Eain A. Murphy +8 more
TL;DR: Two temporally and mechanistically distinct functions used by human cytomegalovirus to down-regulate a cellular antiviral protein are identified.
Journal ArticleDOI
Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2
TL;DR: The genome-wide distribution of the heterochromatin protein 1 (HP1) ortholog HPL-2 is analyzed and both shared and distinctive properties of heterochromeatin relative to other systems are uncovered.
Journal ArticleDOI
PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism.
Siddhant U. Jain,Truman J. Do,Peder J. Lund,Andrew Q. Rashoff,Katharine L. Diehl,Marcin Cieslik,Andrea Bajic,Nikoleta Juretic,Shriya Deshmukh,Sriram Venneti,Tom W. Muir,Benjamin A. Garcia,Nada Jabado,Peter W. Lewis +13 more
TL;DR: The data indicate that PFA ependymoma and DIPG are driven in part by the action of peptidyl PRC2 inhibitors, the K27M oncohistone and the EZHIP ‘oncohist one-mimic’, that dysregulate gene silencing to promote tumorigenesis.