B
Benjamin A. Garcia
Researcher at University of Pennsylvania
Publications - 467
Citations - 40286
Benjamin A. Garcia is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 90, co-authored 425 publications receiving 31491 citations. Previous affiliations of Benjamin A. Garcia include Ludwig Maximilian University of Munich & Purdue University.
Papers
More filters
Journal ArticleDOI
Identifying Host Factors Associated with DNA Replicated During Virus Infection.
Emigdio D. Reyes,Emigdio D. Reyes,Katarzyna Kulej,Katarzyna Kulej,Neha J. Pancholi,Neha J. Pancholi,Lisa N. Akhtar,Daphne C. Avgousti,Daphne C. Avgousti,Eui Tae Kim,Daniel K. Bricker,Daniel K. Bricker,Lynn A. Spruce,Sarah A. Koniski,Steven H. Seeholzer,Stuart N. Isaacs,Benjamin A. Garcia,Matthew D. Weitzman,Matthew D. Weitzman +18 more
TL;DR: This work uncovered host factors deactivated by early viral proteins, and identified a subgroup of nucleolar proteins that aid virus replication that is associated with viral genomes during infection with adenovirus, herpes simplex virus and vaccinia virus.
Journal ArticleDOI
Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny.
Mathieu E. Wimmer,Lisa A. Briand,Bruno Fant,Leonardo A. Guercio,Adrian C. Arreola,Heath D. Schmidt,Simone Sidoli,Yumiao Han,Benjamin A. Garcia,R. C. Pierce +9 more
TL;DR: It is demonstrated that paternal cocaine exposure produces epigenetic remodeling in the hippocampus leading to NMDA receptor-dependent memory formation and synaptic plasticity impairments only in male progeny, which has significant implications for the male descendants of chronic cocaine users.
Journal ArticleDOI
Protein quantification across hundreds of experimental conditions.
TL;DR: This work introduces techniques that combine graph-theoretic algorithms with space-partitioning data structures to collect relative protein abundance data across hundreds of experimental conditions and replicates and demonstrates the scalability of these techniques by applying them to a large dataset.
Journal ArticleDOI
A Global View of RNA-Protein Interactions Identifies Post-transcriptional Regulators of Root Hair Cell Fate
Shawn W. Foley,Sager J. Gosai,Dongxue Wang,Nur Selamoglu,Amelia C. Sollitti,Tino Köster,Alexander Steffen,Eric Lyons,Fevzi Daldal,Benjamin A. Garcia,Dorothee Staiger,Roger B. Deal,Brian D. Gregory +12 more
TL;DR: This global analysis reveals post-transcriptional regulators of plant root epidermal cell fate and finds that SERRATE functions in a microRNA-dependent manner to inhibit hair cell fate, while also terminating growth of root hairs mostly independent of microRNA biogenesis.
Journal ArticleDOI
Bottom-Up and Middle-Down Proteomics Have Comparable Accuracies in Defining Histone Post-Translational Modification Relative Abundance and Stoichiometry
TL;DR: It is evidenced that the middle-down strategy is at least equally reliable to bottom-up in quantifying histone PTMs, as it provided similar performance in defining accurate PTM stoichiometry.