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Benjamin A. Garcia
Researcher at University of Pennsylvania
Publications - 467
Citations - 40286
Benjamin A. Garcia is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 90, co-authored 425 publications receiving 31491 citations. Previous affiliations of Benjamin A. Garcia include Ludwig Maximilian University of Munich & Purdue University.
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SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair.
Sarallah Rezazadeh,David Yang,Seyed Ali Biashad,Denis Firsanov,Masaki Takasugi,Michael Gilbert,Gregory Tombline,Natarajan V. Bhanu,Benjamin A. Garcia,Andrei Seluanov,Vera Gorbunova +10 more
TL;DR: It is shown that the SIRT6 protein enhances non-homologous end joining (NHEJ) DNA repair by transiently repressing transcription and mediates a crosstalk between transcription and DNA repair machineries to promote DNA repair.
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Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma
Nargess Farhangdoost,Cynthia Horth,Bo Hu,Eric Bareke,Xiao Chen,Yinglu Li,Mariel Coradin,Benjamin A. Garcia,Chao Lu,Jacek Majewski +9 more
TL;DR: In this paper, the authors used genome-wide approaches and genome editing to dissect the downstream effects of loss of NSD1 in head and neck squamous cell carcinomas (HNSCCs).
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Stable Isotope Labeling of Phosphoproteins for Large-scale Phosphorylation Rate Determination
TL;DR: Stable isotope labeling of amino acids by phosphate is used to identify sites that have different phosphorylation kinetics during G1/S and M phase, and it is found that most sites had very similar phosphorylated rates under both conditions; however, a small subset of sites on proteins involved in the mitotic spindle were more activelyosphorylated during M phase.
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Sites Contributing to TRPA1 Activation by the Anesthetic Propofol Identified by Photoaffinity Labeling
Kellie A. Woll,Kenneth Arthur Skinner,Eleonora Gianti,Natarajan V. Bhanu,Benjamin A. Garcia,Vincenzo Carnevale,Roderic G. Eckenhoff,Rachelle Gaudet +7 more
TL;DR: It is confirmed that meta-azipropofol activates TRPA1 like the parent anesthetic, and two photolabeled residues (V954 and E969) in the S6 helix are identified, suggesting that the A-967079 cavity is a positive modulatory site for propofol.
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The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage.
TL;DR: The data suggest specific Asp/Glu residues are unlikely to be critical for DNA damage repair and rather that this process is likely dependent on ADP-ribosylation of the nucleosomal surface in general.