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Benjamin A. Garcia
Researcher at University of Pennsylvania
Publications - 467
Citations - 40286
Benjamin A. Garcia is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 90, co-authored 425 publications receiving 31491 citations. Previous affiliations of Benjamin A. Garcia include Ludwig Maximilian University of Munich & Purdue University.
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Journal ArticleDOI
High-Resolution Mapping of RNA-Binding Regions in the Nuclear Proteome of Embryonic Stem Cells.
Chongsheng He,Simone Sidoli,Robert Warneford-Thomson,Deirdre C. Tatomer,Jeremy E. Wilusz,Benjamin A. Garcia,Roberto Bonasio +6 more
TL;DR: Proteomic identification of RNA-binding regions (RBR-ID) is a powerful tool to map protein-RNA interactions and will allow rational design of mutants to dissect their function at a mechanistic level.
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Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency
Rupa Sridharan,Michelle Gonzales-Cope,Constantinos Chronis,Giancarlo Bonora,Robin McKee,Chengyang Huang,Sanjeet G. Patel,David Lopez,Nilamadhab Mishra,Matteo Pellegrini,Michael Carey,Benjamin A. Garcia,Kathrin Plath +12 more
TL;DR: These findings demonstrate that Cbx3 and H3K9 methylation restrict late reprogramming events, and suggest that a marked change in global chromatin character constitutes an epigenetic roadblock for reprograming.
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A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation
Benoit Laurent,Lv Ruitu,Jernej Murn,Jernej Murn,Kristina Hempel,Ryan Ferrao,Yang Xiang,Yang Xiang,Shichong Liu,Benjamin A. Garcia,Hao Wu,Hao Wu,Hao Wu,Feizhen Wu,Hanno Steen,Yang Shi,Yang Shi +16 more
TL;DR: Insight is provided into mechanisms by which LSD1 mediates H3K9me demethylation and alternative splicing is highlighted as a means bywhich LSD1 acquires selective substrate specificities to differentially control specific gene expression programs in neurons.
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Histone H3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells
Wei Xie,Chunying Song,Nicolas L. Young,Adam S. Sperling,Feng Xu,Rupa Sridharan,Anne E. Conway,Benjamin A. Garcia,Kathrin Plath,Amander T. Clark,Michael Grunstein +10 more
TL;DR: The results suggest that K56Ac is involved in the human core transcriptional network of pluripotency, and more accurately reflects the epigenetic differences between hESCs and somatic cells than other active histone marks such as H3 K4 trimethylation and K9 acetylation.
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Capturing the Onset of PRC2-Mediated Repressive Domain Formation.
Ozgur Oksuz,Varun Narendra,Chul Hwan Lee,Nicolas Descostes,Gary LeRoy,Ramya Raviram,Lili Blumenberg,Kelly R. Karch,Pedro P. Rocha,Pedro P. Rocha,Benjamin A. Garcia,Jane A. Skok,Danny Reinberg +12 more
TL;DR: The principles of de novo establishment of PRC2-mediated repressive domains across the genome are demonstrated and shown to be effective at both the cis and far-cis levels.