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Benjamin A. Garcia
Researcher at University of Pennsylvania
Publications - 467
Citations - 40286
Benjamin A. Garcia is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 90, co-authored 425 publications receiving 31491 citations. Previous affiliations of Benjamin A. Garcia include Ludwig Maximilian University of Munich & Purdue University.
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Journal ArticleDOI
Sequential Window Acquisition of all Theoretical Mass Spectra (SWATH) Analysis for Characterization and Quantification of Histone Post-translational Modifications
Simone Sidoli,Shu Lin,Lei Xiong,Natarajan V. Bhanu,Kelly R. Karch,Eric Johansen,Christie L. Hunter,Sahana Mollah,Benjamin A. Garcia +8 more
TL;DR: Sequential window acquisition of all theoretical mass spectra proved to be an easy-to-use MS acquisition method to perform high quality MS/MS-based quantification of histone-modified peptides.
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Histone deacetylase 9 deficiency protects against effector T cell-mediated systemic autoimmunity.
Kailin Yan,Qiang Cao,Christopher M. Reilly,Nicolas L. Young,Benjamin A. Garcia,Nilamadhab Mishra +5 more
TL;DR: Findings suggest that HDAC9 acts as an epigenetic switch in effector T cell-mediated systemic autoimmunity.
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Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence
Payel Sen,Yemin Lan,Catherine Y. Li,Simone Sidoli,Greg Donahue,Zhixun Dou,Brian Frederick,Qijun Chen,Lacey J. Luense,Benjamin A. Garcia,Weiwei Dang,F. Bradley Johnson,Peter D. Adams,Peter D. Adams,David C. Schultz,Shelley L. Berger +15 more
TL;DR: A library of short hairpin RNAs for targeted silencing of all known epigenetic proteins is curated and a high-throughput screen identified multiple new players including the histone acetyltransferase p300 that was found to be a primary driver of the senescent phenotype.
Journal ArticleDOI
Analytical tools and current challenges in the modern era of neuroepigenomics
Ian Maze,Li Shen,Bin Zhang,Benjamin A. Garcia,Ning-Yi Shao,Amanda C. Mitchell,HaoSheng Sun,Schahram Akbarian,C. David Allis,Eric J. Nestler +9 more
TL;DR: A comprehensive overview of available tools for analyzing neuroepigenomics data is provided, as well as a discussion of pending challenges specific to the field of neuroscience.
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Global secretome analysis identifies novel mediators of bone metastasis
Mario Andres Blanco,Gary LeRoy,Zia Khan,Zia Khan,Maša Alečković,Barry M. Zee,Benjamin A. Garcia,Yibin Kang +7 more
TL;DR: This study has uncovered several new secreted mediators of bone metastasis and therefore demonstrated that secretome analysis is a powerful method for identification of novel biomarkers and candidate therapeutic targets.