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Robert W. Haushalter
Researcher at Lawrence Berkeley National Laboratory
Publications - 22
Citations - 658
Robert W. Haushalter is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Acyl carrier protein & Fatty acid. The author has an hindex of 13, co-authored 18 publications receiving 568 citations. Previous affiliations of Robert W. Haushalter include University of California, San Diego & United States Department of Energy.
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Journal ArticleDOI
Trapping the dynamic acyl carrier protein in fatty acid biosynthesis
Chi Nguyen,Robert W. Haushalter,D. John Lee,Phineus R. L. Markwick,Phineus R. L. Markwick,Phineus R. L. Markwick,Joel J. Bruegger,Grace Caldara-Festin,Kara Finzel,David R. Jackson,Fumihiro Ishikawa,Bing O'Dowd,J. Andrew McCammon,J. Andrew McCammon,Stanley J. Opella,Shiou-Chuan Tsai,Michael D. Burkart +16 more
TL;DR: A mechanism-based probe is described that allows active site-selective covalent crosslinking of AcpP to FabA, the Escherichia coli ACP and fatty acid 3-hydroxyacyl-ACP dehydratase, providing insight into pathways that can have major roles in the treatment of cancer, obesity and infectious disease.
Journal ArticleDOI
Production of anteiso-branched fatty acids in Escherichia coli; next generation biofuels with improved cold-flow properties.
Robert W. Haushalter,Woncheol Kim,Theodore A. Chavkin,Megan E. Garber,Melissa Nhan,Paul D. Adams,Christopher J. Petzold,Leonard Katz,Jay D. Keasling +8 more
TL;DR: An Escherichia coli strain is developed that efficiently produces anteiso-branched fatty acids, which can be converted into downstream products with lower cloud and pour points than the mixtures of compounds produced via the native metabolism of the cell.
Journal ArticleDOI
Leveraging microbial biosynthetic pathways for the generation of 'drop-in' biofuels.
Amin Zargar,Constance B. Bailey,Robert W. Haushalter,Christopher B. Eiben,Leonard Katz,Jay D. Keasling +5 more
TL;DR: This review discusses the application of aldehyde decarbonylases to produce gasoline substitutes from fatty acid products, a recently crystallized reductase that could hydrogenate jet fuel precursors from terpene synthases, and the exquisite control of polyketide synthase to produce biofuels with desired physical properties (e.g., lower freezing points).
Journal ArticleDOI
Development of an orthogonal fatty acid biosynthesis system in E. coli for oleochemical production.
Robert W. Haushalter,Robert W. Haushalter,Dan Groff,Dan Groff,Samuel Deutsch,Samuel Deutsch,Theodore A. Chavkin,Simon F. Brunner,Leonard Katz,Jay D. Keasling +9 more
TL;DR: This work reports the first example of in vivo function of a heterologous fatty acid synthase in E. coli and uses FAS1 enzymes for oleochemical production to produce oleochemicals including fatty alcohols and methyl ketones.
Journal ArticleDOI
Fatty Acid and Alcohol Metabolism in Pseudomonas putida: Functional Analysis Using Random Barcode Transposon Sequencing.
Mitchell G. Thompson,Matthew R. Incha,Matthew R. Incha,Matthew R. Incha,Allison N. Pearson,Allison N. Pearson,Allison N. Pearson,M. Schmidt,M. Schmidt,M. Schmidt,William A. Sharpless,William A. Sharpless,Christopher B. Eiben,Christopher B. Eiben,Christopher B. Eiben,Pablo Cruz-Morales,Pablo Cruz-Morales,Pablo Cruz-Morales,Jacquelyn M. Blake-Hedges,Jacquelyn M. Blake-Hedges,Jacquelyn M. Blake-Hedges,Yuzhong Liu,Yuzhong Liu,Catharine A. Adams,Robert W. Haushalter,Robert W. Haushalter,Rohith N. Krishna,Rohith N. Krishna,Patrick Lichtner,Patrick Lichtner,Lars M. Blank,Aindrila Mukhopadhyay,Aindrila Mukhopadhyay,Adam M. Deutschbauer,Patrick M. Shih,Jay D. Keasling +35 more
TL;DR: Functional evidence for the putative roles of hundreds of genes involved in the fatty acid and alcohol metabolism of the Pseudomonas putida bacterium is provided, providing a framework facilitating precise genetic changes to prevent product degradation and to channel the flux of specific pathway intermediates as desired.