B
Bernard Ramsahoye
Researcher at University of Edinburgh
Publications - 29
Citations - 4645
Bernard Ramsahoye is an academic researcher from University of Edinburgh. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 19, co-authored 29 publications receiving 4212 citations. Previous affiliations of Bernard Ramsahoye include Edinburgh Cancer Research Centre & Western General Hospital.
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Journal ArticleDOI
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis
Alexander Meissner,Andreas Gnirke,George W. Bell,Bernard Ramsahoye,Eric S. Lander,Rudolf Jaenisch +5 more
TL;DR: Findings indicate random loss rather than specific maintenance of methylation in Dnmt[1kd,3a−/−,3b−/ −] cells, and suggest that random shotgun bisulfite sequencing can be scaled to a genome-wide approach.
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Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a
Bernard Ramsahoye,Detlev Biniszkiewicz,Frank Lyko,Victoria H. Clark,Adrian Bird,Rudolf Jaenisch +5 more
TL;DR: Analysis of genomic methylation in transgenic Drosophila expressing Dnmt3a reveals that DnMT3a is predominantly a CpG methylase but also is able to induce methylation at CpA and at CPT.
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DNA methylation in Drosophila melanogaster
TL;DR: It is shown that DNA is methylated, but that Drosophila genomic methylation is restricted to the early stages of embryonic development.
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Severe Global DNA Hypomethylation Blocks Differentiation and Induces Histone Hyperacetylation in Embryonic Stem Cells
Melany Jackson,Anna Krassowska,Nick Gilbert,Timothy Chevassut,Lesley M. Forrester,J. D. Ansell,Bernard Ramsahoye +6 more
TL;DR: It is shown that successful terminal differentiation is not dependent simply on adequate methylation levels, and there is an absolute requirement that the methylation be delivered by the maintenance enzyme Dnmt1.
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Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality
Detlev Biniszkiewicz,Joost Gribnau,Bernard Ramsahoye,François Gaudet,François Gaudet,Kevin Eggan,David Humpherys,Mary-Ann Mastrangelo,Zhan Jun,Jörn Walter,Rudolf Jaenisch +10 more
TL;DR: The intrinsic difference between the imprinted region of Igf2 and H19 and of other imprinted genes to postzygotic de novo methylation may be the molecular basis for the frequently observed de noVO methylation and upregulation of IgF2 in neoplastic cells and tumors.