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Bernard Ramsahoye
Researcher at University of Edinburgh
Publications - 29
Citations - 4645
Bernard Ramsahoye is an academic researcher from University of Edinburgh. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 19, co-authored 29 publications receiving 4212 citations. Previous affiliations of Bernard Ramsahoye include Edinburgh Cancer Research Centre & Western General Hospital.
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Journal ArticleDOI
Global hypomethylation of the genome in XX embryonic stem cells
Ilona Zvetkova,Anwyn Apedaile,Bernard Ramsahoye,Jacqueline E. Mermoud,Lucy A. Crompton,Rosalind M. John,Robert Feil,Neil Brockdorff +7 more
TL;DR: DNA methylation is globally reduced in XX ES cell lines and that this is attributable to the presence of two active X chromosomes, and it is shown that hypomethylation is associated with reduced levels of the de novo DNA methyltransferases Dnmt3a and DnMT3b and that ectopic expression of these factors restores global methylation levels.
Journal ArticleDOI
Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression
Tom Latham,Logan Mackay,Duncan Sproul,Muhammed Karim,Jayne Culley,David J. Harrison,Larry Hayward,Patrick R. R. Langridge-Smith,Nick Gilbert,Bernard Ramsahoye +9 more
TL;DR: The results suggest that lactate may be an important transcriptional regulator, linking the metabolic state of the cell to gene transcription, and the primary effect of HDAC inhibition by endogenous short-chain fatty acids like lactate is to promote gene expression at genes associated with HDAC proteins.
Journal ArticleDOI
Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes
James P. Reddington,Sara M Perricone,Colm E. Nestor,Colm E. Nestor,Judith Reichmann,Neil A. Youngson,Masako Suzuki,Diana Reinhardt,Donncha S. Dunican,James G. D. Prendergast,Heidi K. Mjoseng,Bernard Ramsahoye,Emma Whitelaw,John M. Greally,Ian R. Adams,Wendy A. Bickmore,Richard R. Meehan,Richard R. Meehan +17 more
TL;DR: It is shown that hypomethylation leads to widespread H3K27me3 redistribution, in a manner that reflects the local DNA methylation status in wild-type cells, and an intact DNA methylome is required for appropriate Polycomb-mediated gene repression by constraining Polycomb Repressive Complex 2 targeting.
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SAF-A Regulates Interphase Chromosome Structure through Oligomerization with Chromatin-Associated RNAs
Ryu Suke Nozawa,Lora Boteva,Dinesh C. Soares,Catherine Naughton,Alison R. Dun,Adam Buckle,Bernard Ramsahoye,Peter C. Bruton,Rebecca Sonia Saleeb,Maria Arnedo,Bill Hill,Rory R. Duncan,Sutherland K. Maciver,Nick Gilbert +13 more
TL;DR: In this article, the authors show that SAF-A and caRNAs form a dynamic, transcriptionally responsive chromatin mesh that organizes large-scale chromosome structures and protects the genome from instability.
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De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation.
TL;DR: It is demonstrated that the Dnmt3 enzymes methylate predominantly CpG sites and at a low frequency CpA sites with no apparent sequence preferences and confirmed that DnMT3 enzymes, but not Dn mt1, are responsible for de novo methylation.