J
James G. D. Prendergast
Researcher at University of Edinburgh
Publications - 41
Citations - 4893
James G. D. Prendergast is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 20, co-authored 31 publications receiving 4579 citations. Previous affiliations of James G. D. Prendergast include Western General Hospital & Medical Research Council.
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Journal ArticleDOI
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
Brent W. Zanke,Celia M. T. Greenwood,Celia M. T. Greenwood,Jagadish Rangrej,Rafal Kustra,Rafal Kustra,Albert Tenesa,Susan M. Farrington,James G. D. Prendergast,Sylviane Olschwang,Theodore Chiang,Edgar Crowdy,Vincent Ferretti,Philippe Laflamme,Saravanan Sundararajan,Stéphanie Roumy,Jean François Olivier,Frederick Robidoux,Robert Sladek,Alexandre Montpetit,Peter T. Campbell,Stéphane Bézieau,Anne Marie O'Shea,George Zogopoulos,Michelle Cotterchio,Michelle Cotterchio,Polly A. Newcomb,John R. McLaughlin,John R. McLaughlin,Ban Younghusband,Roger C. Green,Jane Green,Mary Porteous,Harry Campbell,Hélène Blanché,Mourad Sahbatou,Emmanuel Tubacher,Catherine Bonaïti-Pellié,Bruno Buecher,Elio Riboli,Sébastien Küry,Stephen J. Chanock,John D. Potter,Gilles Thomas,Steven Gallinger,Steven Gallinger,Thomas J. Hudson,Thomas J. Hudson,Malcolm G. Dunlop +48 more
TL;DR: Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, markers in chromosomal region 8q24 associated with colorectal cancer were identified and this locus has been implicated in prostate cancer.
Journal ArticleDOI
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
Albert Tenesa,Susan M. Farrington,James G. D. Prendergast,Mary Porteous,Marion F Walker,Naila Haq,Rebecca A. Barnetson,Evropi Theodoratou,Roseanne Cetnarskyj,Nicola Cartwright,Colin A. Semple,Andrew G. Clark,Fiona Reid,Lorna Smith,Kostas Kavoussanakis,Thibaud Koessler,Paul D.P. Pharoah,Stephan Buch,Clemens Schafmayer,Jürgen Tepel,Stefan Schreiber,Henry Völzke,Carsten Oliver Schmidt,Jochen Hampe,Jenny Chang-Claude,Michael Hoffmeister,Hermann Brenner,Stefan Wilkening,Federico Canzian,Gabriel Capellá,Victor Moreno,Ian J. Deary,John M. Starr,Ian Tomlinson,Zoe Kemp,Kimberley Howarth,Luis G. Carvajal-Carmona,Emily L. Webb,Peter Broderick,Jayaram Vijayakrishnan,Richard S. Houlston,Gad Rennert,Dennis G. Ballinger,Laura S. Rozek,Stephen B. Gruber,Koichi Matsuda,Tomohide Kidokoro,Yusuke Nakamura,Brent W. Zanke,Brent W. Zanke,Brent W. Zanke,Celia M. T. Greenwood,Celia M. T. Greenwood,Jagadish Rangrej,Jagadish Rangrej,Rafal Kustra,Alexandre Montpetit,Thomas J. Hudson,Thomas J. Hudson,Steven Gallinger,Steven Gallinger,Harry Campbell,Malcolm G. Dunlop +62 more
TL;DR: Findings extend the understanding of the role of common genetic variation in CRC etiology by identifying a previously unreported association, rs3802842 on 11q23, and carrying all six possible risk alleles yielded OR = 2.6 (95% CI = 1.75–3.89) for CRC.
Journal ArticleDOI
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
Ian Tomlinson,Emily L. Webb,Luis G. Carvajal-Carmona,Peter Broderick,Kimberley Howarth,Alan M. Pittman,Sarah L. Spain,Steven J. Lubbe,Axel Walther,Kate Sullivan,Emma Jaeger,Sarah Fielding,Andrew Rowan,Jayaram Vijayakrishnan,Enric Domingo,Ian Chandler,Zoe Kemp,Mobshra Qureshi,Susan M. Farrington,Albert Tenesa,James G. D. Prendergast,Rebecca A. Barnetson,Steven Penegar,Ella Barclay,Wendy Wood,Lynn Martin,Lynn Martin,Lynn Martin,Maggie Gorman,Huw Thomas,Julian Peto,D. Timothy Bishop,Richard Gray,Eamonn R. Maher,Anneke Lucassen,David J. Kerr,D. Gareth Evans,Clemens Schafmayer,Stephan Buch,Henry Völzke,Jochen Hampe,Stefan Schreiber,Ulrich John,Thibaud Koessler,Paul D.P. Pharoah,Tom van Wezel,Hans Morreau,Juul T. Wijnen,John L. Hopper,Melissa C. Southey,Graham G. Giles,Graham G. Giles,Gianluca Severi,Sergi Castellví-Bel,Clara Ruiz-Ponte,Angel Carracedo,Antoni Castells,Asta Försti,Asta Försti,Kari Hemminki,Kari Hemminki,Pavel Vodicka,Alessio Naccarati,Lara Lipton,Judy W. C. Ho,King Yip Cheng,Pak C. Sham,John M. Luk,José A. G. Agúndez,José M. Ladero,Miguel de la Hoya,Trinidad Caldés,Iina Niittymäki,Sari Tuupanen,Auli Karhu,Lauri A. Aaltonen,Jean-Baptiste Cazier,Harry Campbell,Malcolm G. Dunlop,Richard S. Houlston +79 more
TL;DR: Genetic data provide further evidence for the 'common-disease common-variant' model of CRC predisposition and identify two previously unreported associations.
Journal ArticleDOI
Abundant pleiotropy in human complex diseases and traits.
Shanya Sivakumaran,Felix Agakov,Evropi Theodoratou,James G. D. Prendergast,Lina Zgaga,Lina Zgaga,Teri A. Manolio,Igor Rudan,Paul M. McKeigue,James F. Wilson,Harry Campbell +10 more
TL;DR: It is already clear that pleiotropy is a common property of genes and SNPs associated with disease traits, and this will have implications for identification of molecular targets for drug development, future genetic risk-profiling, and classification of diseases.
Journal ArticleDOI
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33
Richard S. Houlston,Jeremy Peter Cheadle,Sara E. Dobbins,Albert Tenesa,Angela M. Jones,Kimberley Howarth,Sarah L. Spain,Peter Broderick,Enric Domingo,Susan M. Farrington,James G. D. Prendergast,Alan M. Pittman,Evi Theodoratou,Christopher Smith,Bianca Olver,Axel Walther,Rebecca A. Barnetson,Michael Churchman,Emma Jaeger,Steven Penegar,Ella Barclay,Lynn Martin,Maggie Gorman,Rachel Mager,Elaine C. Johnstone,Rachel Midgley,Iina Niittymäki,Sari Tuupanen,James Colley,Shelley Idziaszczyk,Huw Thomas,Anneke Lucassen,D. Gareth Evans,Eamonn R. Maher,Tim Maughan,Antigone S. Dimas,Antigone S. Dimas,Emmanouil T. Dermitzakis,Jean-Baptiste Cazier,Lauri A. Aaltonen,Paul D.P. Pharoah,David J. Kerr,David J. Kerr,Luis G. Carvajal-Carmona,Harry Campbell,Malcolm G. Dunlop,Ian Tomlinson +46 more
TL;DR: A meta-analysis of three GWAS from the UK provides evidence that additional CRC-associated variants of similar effect size remain to be discovered and identifies four new CRC risk loci.