H
Helen E. Jolin
Researcher at Laboratory of Molecular Biology
Publications - 33
Citations - 6298
Helen E. Jolin is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Innate lymphoid cell & Immune system. The author has an hindex of 16, co-authored 28 publications receiving 5539 citations.
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Journal ArticleDOI
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Daniel R. Neill,See Heng Wong,Agustin Bellosi,Robin J. Flynn,Maria Daly,Theresa K. A. Langford,Christine Bucks,Colleen M. Kane,Padraic G. Fallon,Richard Pannell,Helen E. Jolin,Andrew N.J. McKenzie +11 more
TL;DR: The identification and functional characterization of a new innate type-2 immune effector leukocyte that is named the nuocyte is presented, which represents a critically important innate effector cell in type- 2 immunity.
Journal ArticleDOI
Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
Padraic G. Fallon,Sarah J. Ballantyne,Niamh E. Mangan,Jillian L. Barlow,Ayan Dasvarma,Duncan R. Hewett,Ann McIlgorm,Helen E. Jolin,Andrew N. J. McKenzie +8 more
TL;DR: It is demonstrated that these IL-25–regulated cells appear rapidly in the draining lymph nodes, implicating them as a source of type 2 cytokines during initiation of worm expulsion.
Journal ArticleDOI
Transcription factor RORα is critical for nuocyte development
See Heng Wong,See Heng Wong,Jennifer A. Walker,Helen E. Jolin,Lesley F Drynan,Emily Hams,Ana Camelo,Jillian L. Barlow,Daniel R. Neill,Daniel R. Neill,Veera Panova,Ute Koch,Freddy Radtke,Clare S. Hardman,You Yi Hwang,Padraic G. Fallon,Padraic G. Fallon,Andrew N J McKenzie +17 more
TL;DR: It is found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously unknown members of the lymphoid lineage.
Journal ArticleDOI
T1/St2-Deficient Mice Demonstrate the Importance of T1/St2 in Developing Primary T Helper Cell Type 2 Responses
Michael J. Townsend,Padraic G. Fallon,David John Matthews,Helen E. Jolin,Andrew N. J. McKenzie +4 more
TL;DR: It is clearly demonstrated that T1/ST2 expression plays a role in the development of Th2-like cytokine responses and indicate that effector functions are inhibited in its absence.
Journal ArticleDOI
Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma.
Sarah J. Ballantyne,Jillian L. Barlow,Helen E. Jolin,Puneeta Nath,Alison S. Williams,Kian Fan Chung,Graham Sturton,See Heng Wong,Andrew N. J. McKenzie +8 more
TL;DR: A novel pathway for the induction of AHR is defined and it is suggested that IL-25 represents an important therapeutic target for the treatment of asthma and blocks the binding of human IL- 25 to its receptor.