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Bibi S. van Thiel
Researcher at Erasmus University Rotterdam
Publications - 6
Citations - 186
Bibi S. van Thiel is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Plasma renin activity & Renin–angiotensin system. The author has an hindex of 4, co-authored 5 publications receiving 154 citations.
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Journal ArticleDOI
The renin-angiotensin system and its involvement in vascular disease.
TL;DR: The beneficial therapeutic effects of inhibition of the RAS on the vasculature are discussed, as well as the need for additive effects on top of RAS inhibition.
Journal ArticleDOI
Brain Renin-Angiotensin System: Does It Exist?
Bibi S. van Thiel,Alexandre Goes Martini,Luuk te Riet,David Severs,Estrellita Uijl,Ingrid M. Garrelds,Frank P.J. Leijten,Ingrid van der Pluijm,Jeroen Essers,Fatimunnisa Qadri,Natalia Alenina,Michael Bader,Ludovit Paulis,R. Rajkovicova,Oliver Domenig,Marko Poglitsch,A.H. Jan Danser +16 more
TL;DR: In this paper, the authors quantified brain renin, before and after buffer perfusion of the brain, in wild-type mice, renin knockout mice, deoxycorticosterone acetate salt-treated mice, and Ang II-infused mice.
Journal ArticleDOI
Extracellular Matrix Defects in Aneurysmal Fibulin-4 Mice Predispose to Lung Emphysema
Natasja W. M. Ramnath,Koen M. van de Luijtgaarden,Ingrid van der Pluijm,Menno van Nimwegen,Paula M. van Heijningen,Sigrid M. A. Swagemakers,Bibi S. van Thiel,Ruziedi Y. Ridwan,Nicole van Vliet,Marcel Vermeij,Luuk J. A. C. Hawinkels,Anne de Munck,Oleh Dzyubachyk,Erik Meijering,Peter J. van der Spek,Robbert J. Rottier,Hiromi Yanagisawa,Rudi W. Hendriks,Roland Kanaar,Ellen V. Rouwet,Alex KleinJan,Jeroen Essers +21 more
TL;DR: It is shown that COPD is significantly more prevalent in aneurysm patients compared to arterial occlusive disease patients, independent of smoking, other clinical risk factors and inflammation.
Journal ArticleDOI
AT1-receptor blockade, but not renin inhibition, reduces aneurysm growth and cardiac failure in fibulin-4 mice
Luuk te Riet,Elza D. van Deel,Bibi S. van Thiel,Els Moltzer,Nicole van Vliet,Yanto Ridwan,Richard van Veghel,Paula M. van Heijningen,Jan Lukas Robertus,Ingrid M. Garrelds,Marcel Vermeij,Ingrid van der Pluijm,A.H. Jan Danser,Jeroen Essers +13 more
TL;DR: Losartan, but not aliskiren or propranolol, improved survival in fibulin-4R/R mice, which most likely relates to its capacity to improve structure and function of both aorta and heart.
Journal ArticleDOI
DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice
Martine de Boer,Maaike te Lintel Hekkert,Jiang Chang,Bibi S. van Thiel,Leonie Martens,Maxime M Bos,Marion G J de Kleijnen,Yanto Ridwan,Yanti Octavia,Elza D. van Deel,Lau Blonden,Renata M. C. Brandt,Sander Barnhoorn,Paula K Bautista-Niño,Ilona Krabbendam-Peters,Rianne Wolswinkel,Banafsheh Arshi,Mohsen Ghanbari,Christian Kupatt,Leon J. De Windt,A.H. Jan Danser,Ingrid van der Pluijm,Carol Ann Remme,Monika Stoll,Joris Pothof,Anton J.M. Roks,Maryam Kavousi,Jeroen Essers,Jolanda van der Velden,Jan H.J. Hoeijmakers,Dirk J. Duncker +30 more
TL;DR: In this paper , the authors tested the hypothesis that endogenous DNA repair in cardiomyocytes is critical for maintaining normal cardiac function, so that perturbed repair of spontaneous DNA damage drives early onset of heart failure.